Plant Sciences' contribution to the Evolution & Biodiversity research theme is to understand what are the key drivers of plant biodiversity during evolution with a focus on plant life history and resilience traits and develop tools to restore and maintain plant biodiversity.

Accumulation of metals in economy and environment and its associated risks, within the Netherlands and the EU.

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

CML’s education programme aims at training (under)graduate and graduate students for integrated and multidisciplinary sustainability research and for better decision making in managing the world’s natural resources, environmental quality and biodiversity.

Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…

The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

What is the size and composition of the Dutch urban mine? How will the urban mine develop over time, and how can it be used as a source of materials as part of a circular economy?

Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

They can play a role in metabolic disorders and can break down tough plant fibers: β-glycosidases are enzymes that play many roles in nature. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean energy and to improve the treatment of patients with metabolic diseases.

Martina G. Vijver has been appointed professor of Ecotoxicology at the Institute of Environmental Sciences of Leiden University with effect from 1 December 2017.

On Thursday the 24th of November, Tseard Hoekstra and Jeroen Ververs (members of the delegation Holland Rijnland), Geert de Snoo (Dean Faculty of Science), Martina Vijver (CML), Herman Spaink (Scientific Director IBL) and Klaas Vrieling (IBL) explored possibilities for collaborations between companies…

Students searched for a student project about internalization and the effects of nanomaterials in freshwater organisms. Open to BSc and MSc students and any timeframe.

Microplastics are small pieces of plastic found in the environment. At CML research have been conducted in the distribution of these plastics on beaches around the world using citizen science. In addition, CML is conducting in depth case-studies in the Caribbean and along the Dutch coast. Follow-up…

By analysing the metabolism using big data techniques, we can identify health risks at an earlier stage. Thomas Hankemeier, professor of Analytical Biosciences at the Leiden Academic Centre for Drug Research, explains how that works.

Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…

On 22 January 2018, the Massive Open Online Course ’A Circular Economy of Metals: Towards a Sustainable Societal Metabolism’ kicks off. This course is developed and taught by associate professor Ester van der Voet.

Environmental researcher Martina Vijver is over the moon with her ERC Consolidator Grant. This prestigious grant is recognition, she says, of the study of the behaviour and possible toxicity of new nanomaterials in ecosystems.

Students searched for MSc Internships under the following topics: 1. Understanding temporal variability in functional biodiversity and 2. Characterization of engineered nanoparticles in aquatic organisms: Gold nanoparticles and carbon nanotubes

In the field of metabolomics, capillary electrophoresis-mass spectrometry (CE-MS) has become a very useful analytical technique for the profiling of highly polar and charged metabolites in biological samples. In order to highlight the unique features of CE-MS for metabolomics studies, Dr. Rawi Ramautar…

The Netherlands Organisation for Scientific Research (NWO) has awarded Veni funding to seventeen researchers who recently obtained their PhD. This award offers promising young scientists the opportunity to develop their own ideas over a period of three years.

LACDR, the Leiden Institute for Drug Research, developed better tolerated excipients to prevent adverse effects related to the surface of nanosized drugs such as vaccines. LADCR professor of Biopharmacy Matthias Barz and Polypeptide Therapeutic Solutions (PTS) are collaborating to develop processes…

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

The Leiden Academic Centre for Drug Research (LACDR) is responsible for the research and education in Bio-Pharmaceutical Sciences carried out at Leiden University.

Nano-plastics cause malformations. Meiru Wang, researcher at the Institute of Biology Leiden, looked at the extreme effects polystyrene nano-particles could have, using chicken embryos as a model. Her results were quite alarming. Especially as nano-particles are everywhere. In the air, floating through…

We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…

Every year, the World Cultural Council grants special acknowledgements to five to ten young researchers or scholars of the host country who have achieved outstanding performance in the fields of science, education or arts.

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

The world is becoming clogged with plastic, with tiny plastic particles found everywhere, from the oceans’ depths to the mountain tops, soil, plants, animals and even inside us. The question is: what harm, if any, are they causing? In a new article on The Conversation, environmental scientists Meiru…

Sander Blok has won the third edition of the annual LION Image Award. He created a colorful image of gold nanoparticles with a low-energy electron microscope.

Tuesday May 24th, the LACDR Annual Spring Symposium was held.

Fighting against cancer, antibiotic resistance and disposable plastics: Ahmed Ali, Fredj Ben Bdira, and Valerio Barbarossa receive a LUF grant for their innovative and socially relevant research. These grants for academic talent are often an important step towards grants by NWO and other grant insti…

On Friday 17 April Leiden Mayor Henri Lenferink will officially open the new Metabolomics Facility of Leiden University. The facility’s ultimate goal is to prevent disease and to improve health throughout the human lifespan.

In her inaugural lecture on 11 September, Miranda van Eck, Professor of Cardiovascular and Metabolic Therapeutics, addressed her research related to developing medications to keep our blood vessels clean.

At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells. This is what an international group of researchers from Leiden University and Erasmus MC, among others,…

Researchers at the Universities of Amsterdam (Uva) and Leiden together with the Netherlands Cancer Institute and Oncode Institute have received a €10,6 million ERC Synergy Grant to develop innovative therapeutic approaches to target glioblastoma. This is a deadly primary brain tumour for which no curing…

In otherwise energetic desserts at the bottom of the sea, researchers have found oases where microbes can harvest energy. Remarkably, the microbes first have to be buried under starving conditions for 80,000 years. An international group of researchers, amongst them José Mogollón from the Insitute of…

Professor of Ecotoxicology Martina Vijver had planned an eight-week field work course for her students, but the corona virus threw a spanner in the works and Vijver had to come up with a new plan at short notice. ‘Without the help of my own network and that of my colleagues this would have been very…

The ‘Stans Prize 2014' (for the best thesis, report or article produced by a CML student) has been awarded to Myrthe Fonck. Other CML prizes were awarded to David Font Vivanco, Ester van der Voet, Martina Vijver and Paul van den Brink.

It's now possible to measure how many plastic particles there are in our food. Chinese scientists and Leiden professor Willie Peijnenburg applied their new method to lettuce and wheat. Their results were published January 20 in Nature Nanotechnology.

Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…

The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…

Over the past century, the world population has grown exponentially, as has our need for energy and raw materials. If we wish to continue to live prosperously in the future, we have to radically restructure our economy and consumption. Scientific research shows us how to do this.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

The Data Science Research Programme at Leiden University combines data science with PhD projects in a wide range of disciplines. The programme has been running for over two years, and is producing the first astonishing results. A number of PhD candidates talk about their experiences and research bel…