We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

How is energy really dissipated on the atomic scale when sliding objects slip over a single lattice spacing?

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Legitimacy is generally a term that is associated with the state. The term surfaces when there are problems with state legitimacy—when it is lacking or absent. This present volume attempts to think through the relevance of the concept of legitimacy for other political actors than the state.

An archaeological case-study of the Pointe des Châteaux, La Désirade and Les Îles de la Petite Terre micro-region, Guadeloupe, F.W.I.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Research in the van Exter lab focuses on quantum aspects of light and light-matter interaction. One of our long-term goals is to develop a reliable quantum memory, based on a single emitter in an open micro cavity.

Promotor: J.W.M. Frenken

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

Microneedles represent promising tools for delivery of drugs to the skin. However, before these microneedles can be used in clinical practice, it is essential to understand the process of skin penetration by these microneedles.

Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

This thesis presents a thorough survey of the central aspects of the phonology of Shaoxing Chinese from a synchronic perspective and on the basis of recent theoretical phonological developments, with the secondary goal of casting some light on current issues in Modern Chinese (Mandarin).

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

Discover the connection between skateboarding and sensory ethnography in 32 of The Routledge International Handbook of Sensory Ethnography as part of the Multi-modal sensory ethnography.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

This thesis presents a detailed description of the phonology, the tone system and the grammar of Liko, a Bantu language spoken by about 70,000 people in the northeastern part of the Democratic Republic of the Congo. It provides numerous examples.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

A study of the technology, form, function, and use of pottery from the settlements Uitgeest-Groot Dorregeest and Schagen-Muggenburg 1, Roman Period, North-Holland, the Netherlands

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

This paper sheds light on how better monetary-fiscal coordination can be expected to play out across very different political-economic contexts.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Lecture

Lecture

Lecture

An overview of awards and prizes granted to our staff and students in 2021, as well as special appointments at Leiden University and other institutions.

As a venue, Leiden University is a fitting setting for recognising the outstanding achievements of the award winners and celebrating the inspiration that they bring as role models for encouraging a fairer society by motivating one individual at a time.

Lecture

Lecture

Lecture

Lecture

Lecture

Defending your PhD research in front of nearly 300 elementary school students: that was the challenge faced by PhD candidates Jo-Anne Verschoor and Marinka de Willigen during the VUURVLIEGEN competition organised by the Centrum JongerenCommunicatie Chemie (C3). After an exciting competition, the children…

Lecture

PhD defence

Lecture

Dr Bela Bode receives a Feodor Lynen research fellowship for postdoctoral researchers by the Alexander von Humboldt-Foundation for development of new methods for signal enhancement in solid state NMR. He aims to create a specific analytical tool for surface studies and research on membranes and membrane…