Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…

Nanoparticles that transport medicines to a specific part of the human body are usually broken down in the liver prematurely. Jeroen Bussmann from Leiden University has discovered a new method to prevent this from happening. Publication in ACS Nano.

PhD defence

- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?

Physics and Engineering Approaches to Biomedicine and Pharmacology

Urbanization brings benefits like housing and jobs but also challenges like biodiversity loss. CML's Urban research program uses science to create sustainable cities, focusing on the built environment (circular economy, urban mining) and enhancing urban nature for biodiversity and human benefits.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

The "Van Marum Colloquia" are a collaborative lecture series between the LION and LIC institutes, focusing on fundamental and applied surface science.

Conference

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…

Development of Comprehensive and High-throughput metabolomics techniques and Clinical applications of (pharmaco)metabolomics

Research at the BIOSYN group is comprised of the following research themes:

Can epigenetic changes explain associations between early life stress and health outcomes?

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

An overview of research themes and projects at ABS.

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.

Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.

Contact information & Visitors address

Water, Urbanism, and Sustainability in Roman Ostia

The Faculty of Medicine

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Within the Chinese medicine, more than 80% of the constituents of the preparations are derived from plants. Like any other organism, plants are constantly interacting with their changing and often harsh environment during the various phases of their life cycle.

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.

How do nanoparticles bioaccumulate and biodistribute in organisms?

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Twenty years from now, the world population is estimated to be around 9 billion people (now 8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this population will result in an enormous increase in the demand for food, consumables, water…

Research at the SBC group is comprised of the following research themes:

Chemical substances and nanomaterials are processed on a massive scale in diverse products, while their risks have not been properly assessed. Time and again synthesised substances have been shown to pollute the environment more than lab tests predicted. This is the warning given by Professor of Ecotoxicology…

Water fleas and damselflies are much more sensitive to crop protection products in nature than in the lab. These test results from the Living Lab were presented by Henrik Barmentlo and Martina Vijver in Dutch radio show Vroege Vogels.

Leiden researchers have carried out successful tests using a new method of packaging a cancer vaccine in nano-particles. The new vaccine has induced a strong immune reaction in mice. The researchers believe that this method can make an important contribution to the treatment of cancer. Their findings…

- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?

Overview of all dissertations published by PhD candidates from CML.

Data science is now growing fast in many places, but scholars at Leiden University have been developing data science techniques for a long time already. Thanks to their broad-based expertise, Leiden statisticians are currently combining the achievements in statistics with the latest methods of statistical…

How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?

How might we include circularity into the models often used in IPCC reporting (in technical language, how can IAMs, dMFA models and CGE models be integrated?) What are possible futures for global resource use and what are the consequences for greenhouse gas emissions in these scenarios?

Welcome to the website of Diversity, Equity, and Inclusion (DEI) team. DEI team at LACDR works towards embracing the beauty of differences in genders, religions, nationalities, and other characteristics of all humans.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Plant Sciences' contribution to the Evolution & Biodiversity research theme is to understand what are the key drivers of plant biodiversity during evolution with a focus on plant life history and resilience traits and develop tools to restore and maintain plant biodiversity.

Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

What are the functions of autophagy in the filamentous fungus Aspergillus niger?

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.