How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Up to 45% of patients with Parkinson's disease experience impulse control disorders, characterised by a loss of voluntary control over impulses, drives or temptations. This study aimed to investigate whether previously identified genetic and psychiatric risk factors interact towards the development…

Self-driving cars, surgery robots, and stock market algorithms: the use of robots and Artificial Intelligence (AI) is rapidly increasing. What are the opportunities for this development, and what the dangers? The Honours Class ‘Robot Law: Regulating Robot and AI Technologies’ prepares students for the…

Getting personal

The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

Challenges for the protection of traditional knowledge and genetic resources, traditional cultural expressions, and traditional knowledge of indigenous peoples in the international scenario.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Do you have questions about the master’s specialisation Molecular Genetics and Biotechnology? Please contact us.

Find out how to apply for Molecular Genetics and Biotechnology at Leiden University by following our step-by-step guide.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

e-SIDES (ethical and societal impact of data sciences) is a Coordination & Support Action (CSA) part of the Horizon 2020 programme.

A linguistic test of hypotheses rooted in genetics and archaeology.

The specialisation consists of 120 European Credit Transfer System (EC) points and includes courses and electives (30 - 60 EC) and and one or more research projects (60 - 90 EC).

Do understudied animals contain hidden species?

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

With tomography it is possible to reconstruct the interior of an object without destroying.

The Leiden-Delft-Erasmus Centre for BOLD Cities uses data research to help solve urban issues. Three interdisciplinary research projects will begin soon. Leiden sociologist John Boy explains.

In this research project, the protection of personal data is compared in eight EU member states: France, Germany, the UK, Ireland, Romania, Italy, Sweden and the Netherlands. The comparison of the countries is focused on government policies for the protection of personal data, the applicable laws and…

Policy makers urgently need scientists’ help with the phenomenon of big data. This was the view expressed by Prince Constantijn, speaking at the opening of the Leiden Centre of Data Science, the virtual centre for research on big data at Leiden University.

The Leiden Institute of Advanced Computer Science (LIACS) received a grant award from NWO for a joint proposal with Centrum Wiskunde & Informatica (CWI, Amsterdam), Tata Steel (IJmuiden), BMW (Munich), and database company MonetDB. Within the NWO Data Science program ‘challenging big data‘, LIACS is…

In this dissertation, we study partition-based models that can be used both for interpretable predictive modeling and for understanding data via interpretable patterns.

Companies like Facebook and Google make billions of dollars by selling or using our personal data. The data could be used by many different entities for many different reasons: from universities for research, to brands for creating targeted ads. But rather than just giving their data away to these companies…

A novel in vivo model system for studies on glucocorticoid resistance

What issues arise in the changing landscape of privacy, identity and data protection?

Comparison across jurisdictions is one way of assessing the appropriateness of lethal force resulting from the actions of law enforcement agencies. This article sets out a vision for a global use of force monitor that can enable meaningful comparisons between law enforcement agencies. It examines some…

The Leiden Ranking – Open Edition is completely transparent. The ranking compiled by the CWTS uses open data and publishes the algorithms that are used.

On 31 May, GTGC Chair Prof. Jan Aart Scholte, together with Carolina Aguerre and Malcolm Campbell-Verduyn, launched their book 'Global Digital Data Governance: Polycentric Perspectives' at the University of Groningen.

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

PhD defence

A neurobiological perspective on individual differences in social competence

The group is involved in training in areas of diagnostic skills, treatment/prevention/intervention, neuropsychological assessment, behavioral observations, clinical interviewing, knowledge of intellectual disability, autism, ADHD, psychosis and aggression.

Morphometric and morphological differences have been used extensively in the past to study domestication of the wolf and the origin of dogs. Certainly before genetic testing was performed, these methods were the only means to diverge both groups. But still now, when aDNA cannot be extracted, morphometry…

Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.

Desafios para a proteção dos conhecimentos tradicionais, dos recursos genéticos e das expressões culturais tradicionais dos povos indígenas no cenário internacional

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa