2,637 search results for “discovery of the yuan” in the Public website
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Contact
Do you have questions about the Bio-Pharmaceutical Sciences master’s programme or the specialisation Drug Discovery and Safety? Please contact us.
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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CCLS Past Events
On this page you can find information about previous CCLS events.
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Queen Máxima inspects zebrafish embryos
On Wednesday the 4th of September, Queen Máxima opened the renovated tropical greenhouse complex of the Leiden Hortus Botanicus. At the occasion Máxima met with IBL-PhD student Mahin Ghorbani from Iran and talked with her about her work on drug discovery from Iranian medicinal plants using zebrafish…
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Why Brainpower can hold his own against Harry Mulisch
In terms of the breadth of their vocabulary, many Dutch rappers can easily match leading authors. This is the surprising conclusion drawn by language researcher Alex Reuneker on the basis of comparative research. Rapper Brainpower and author Ilja Leonard Pfeiffer will debate this issue on 16 September…
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The Top 450 is growing: entry number 50 published
The 50th Top 450 entry has now been published. In the run-up to the university’s 450th anniversary, we are compiling our Top 450. What is your favourite?
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Bio-organic Synthesis
The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…
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Now available: Open Science: A Practical Guide for Early-Career Researchers
This practical guide is aimed at PhD candidates, Research Master Students, and early-career researchers from all academic disciplines. The instructions in the guide intend to inspire young researchers and to help them practice Open Science, by sharing all aspects of research as open possible.
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Bacteria under stress can live without cell wall
Thread-like bacteria make cells that no longer have a cell wall under the influence of osmotic stress. A remarkable discovery, since the cell wall serves as a protection barrier for bacteria. It could also help to explain how pathogenic bacteria can hide in our body from our immune system. A team of…
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Meet the professor in The Hague
Leiden University's professors will be going to elementary schools again to teach about science and research. During the class discovery-based learning will be central. The professors will go to several schools in The Hague. The classes are part of the university's celebration of its 445th birthday…
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Computational Network Science Lab
The Leiden Computational Network Science Lab (CNS Lab) researches methods for knowledge discovery from real-world network data.
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Formation of synthetic fuel: new insights!
Navarro Paredes
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Projects
The Young Academy Leiden and its workgroups have launched different initiatives in the interest of early-career scholars. Read all about the different projects of the Young Academy Leiden here.
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Applied String Theory: Explaining Quantum Matter with Black Holes
Schalm
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Key publications
Key publications of the Cancer Drug Target Discovery group
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LED3 Lectures
The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL) and the Leiden Academic Centre for Drug Research (LACDR), is very excited to organize the “LED3 Lectures”. This lecture series brings world-leading researchers in the field of…
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C.J. Kok Jury Award for Thesis of the Year
Isotopes on exoplanets, a more efficient memory for data centres or new molecules that work against the Zika virus and HIV. Which PhD candidate has written the most impressive dissertation of 2023? The jury of the C.J. Kok Jury Award faces the challenging task of deciding that. Meet the nominees of…
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
PhD defence
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LED3 Chemical Biology Talk: Cyclic Peptides in Target Discovery
Lecture
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Antibiotic Discovery: From mechanistic studies to target ID
PhD defence
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Leiden planetary experts want to study seven ‘Earths’ in more detail
Astronomers have discovered seven Earth-like planets around a dwarf star in our galaxy. Three of these planets are located in the habitable zone of this star, and may contain liquid water. ‘The next step is to study the atmospheres for signs of life. In Leiden we are experts in that area,‘ says planetary…
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MicroRNA: so small but so very important
The discovery in 2001 of the importance of microRNAs turned the world of molecular biology upside down. The small particles of RNA also attracted the attention of university lecturer Erno Vreugdenhil. Vreugdenhil: ‘Within five to ten years the first microRNA-directed medicines will come onto the mar…
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NEXUS 1492. New World Encounters in a Globalising World
What are the immediate and lasting effects of the colonial encounters on indigenous Caribbean cultures and societies and what were the intercultural dynamics that took place during the colonisation processes? How can the study of indigenous Caribbean histories contribute to a more sophisticated awareness…
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AiChemist project
The AiChemist project (https://aichemist.eu) coordinated by Helmholtz Munich is an Innovative Doctoral Training Network funded through the Marie Skłodowska-Curie Actions (MSCA-DN) within the EU Horizon Research Framework, to the sum of €3 million. It brings together leading experts in AI, chemoinformatics…
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Glyco(proteo)mic Workflows for Cancer Biomarker Discovery
PhD defence
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Madouc Bergers made her own enzyme inhibitors for her bachelor’s thesis
For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…
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From data to discoveries: machine learning and optimization in space
Lecture
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Education
Studying linguistics at the Leiden University Centre of Linguistics (LUCL) is a challenging but rewarding experience. There are few places in the world where such a broad range of languages are studied from so many different perspectives.
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Top 450
What is the best thing ever about Leiden University?
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Bioactive Molecules
Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.
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‘Building blocks for life' may originate in space
Amino acids are the building blocks for life on earth. They may originate in space and reach the Earth via comets and meteorites. Daniël Paardekooper examined part of this hypothesis. PhD defence on 5 July.
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Month of Tutankhamun: Egypt's most legendary pharaoh
November marks exactly 100 years since the discovery of Tutankhamun's tomb. To celebrate this special discovery, the Faculty of Humanities, together with various parties, is organising the 'Month of Tutankhamun': a month full of activities around Egypt's most legendary pharaoh.
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Human DNA softer than DNA single-celled life
Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.
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Language as a time machine
By studying language you can reconstruct the history of different communities, even when no other historical sources, such as written documents, are available. In the coming years, researchers Willem Adelaar and Marian Klamer will be carrying out this kind of reconstruction in areas of great linguistic…
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Excavations at Neumark
The Middle Paleolithic site of Neumark was first discovered in the 1980’s by German geologist Matthias Thomae.
- The Belgian Archaeological Mission to Elkab
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First direct detection of a brown dwarf with a radio telescope
Astronomers at ASTRON and Leiden University have used the LOFAR radio telescope to discover a 'brown dwarf' – a faint object more massive than Jupiter, but significantly less massive than the Sun. The discovery of the object dubbed Elegast, opens up a new path that uses radio telescopes to discover…
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Master student Maddalena Centanni awarded with Arenberg-Coimbra Group Prize
Former masterstudent Bio-Pharmaceutical Sciences Maddalena Centanni will be awarded the 2020 Arenberg Coimbra Prize for Erasmus Students. Centanni spent her six month Erasmus exchange at Uppsala Universiy in Sweden where she looked for ways to improve anti-cancer drug dosing.
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Two-pronged attack on infectious diseases
A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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Landscapes of Survival
The Archaeology and Epigraphy of Jordan’s North-Eastern Desert and Beyond
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Palaeolithic fieldschool Barnham UK 2016
This summer seven students from the Faculty of Archaeology crossed the North Sea to assist in the British Museum excavations at East Farm, Barnham, Suffolk, UK – a Middle Pleistocene site. Together with five students from the UK they went through many stages of fieldwork, from scooping the English weather…