The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotor: A. Kros

Master projects are available in

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Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Comparing the global warming potential (GWP) of the service provided by an iRex Digital Reader to the same service provided by an office printer using a scanning LCA.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

Can we tailor catalysts at the atomic scale by means of high-school chemistry and geometry rules?

Schalm

Leiden physicists have managed to detect a single molecule called dibenzoterrylene in a new crystal, and found that it is a candidate component for a quantum network. Future quantum computers will need such a network to work together while maintaining their advantages. Publication in ChemPhysChem jo…

The Leiden Institute of Physics hosted the annual conference of the Dutch Vacuum Society (NEVAC). Experts in the field of vacuum experiments talked about their research. The 2016 NEVAC Prize was awarded to PhD student Martijn Vos from the TU Eindhoven.

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

The Phase 3 clinical trial results of the promising Covid-19 vaccine of Johnson & Johnson are expected this month. The Dutch electron microscopy facility NeCEN helped develop the company’s vaccine, and they have now published their scientific findings in Nature Communications.

PhD defence

A full overview of MacBio PhD Theses.

With a pioneering project like the quantum computer, it’s a good idea not to place all your bets on a single horse. In Leiden’s Quantum Optics research group, instead of working on a Majorana-based qubit, people are working on a qubit based on an ‘artificial atom’. If that becomes the basis of the quantum…

Training and learning in the field of Health Care

Below you will find a collection of books, other than those in the BLRN book series, to which members of BLRN have contributed.

We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…

For the first time ever, Leiden biologists have found that the ‘nose’ of spirochetes – worm-shaped bacteria – have a two-fold symmetry. A remarkable discovery, as the ‘nose’ of every other bacterium has been found to have a six-fold symmetry. First author Alise Muok wrote a popular blog about the findings…

As of 1 June, Leiden University has appointed Sense Jan van der Molen as Professor Physics of Condensed matter. He investigates the unique electronic properties that arise when atomic thin layers are stacked on top of each other into new materials.

Multidrug-resistant pathogens and worldwide pandemics are increasing, making infectious diseases more prevalent. To develop new treatments, deeper knowledge of the interaction between bacteria and human cells is required. Ariane Briegel recently became a Medical Delta professor and studies such path…

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:

Research at the MCBIM group is comprised of the following research themes:

In the Aarts lab we combine or structure materials, mostly in thin film form, in such a way that the hybrid has different and novel properties or functionalities.

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

A lot of our research is performed at temperatures close to absolute zero, among other reasons because this increases the sensitivity of the measurements. 

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Promotor: Prof.dr. M.A.G.J. Orrit

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Study of human cultures using computational approaches

Last Monday April 18, Bram Koster (professor at the Institute of Biology Leiden (IBL), professor at the Leiden University Medical Center (LUMC)) and Ariane Briegel (professor at the IBL) gave a presentation to the mayor of Leiden, Henri Lenferink. The presentation took place at NeCEN, the open access…

Mapping of bacterial genomes to combat infectious diseases

In 2021 we will start with a weekly lunch time seminar series, online on Mondays from 12 noon onwards.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Governments are increasingly facilitating the roll-out of so-called “smart meters”, a technology for measuring energy consumption that are able to transmit and receive data using a form of electronic communication. However, implementation has been slow or even stalled.

Modern society is connected through electronic and mobile devices, which we call the Internet of Things (IoT).

As part of LUGO’s focus on responsible recycling of e-waste (electronic waste) we participated in the Funky Phone Challenge.

The physics of black holes appears to be as far removed from the physics of electrons in metals as it can be.

The focus of our theoretical physics research is the nature of macroscopic matter that is in one or the other way still in the grip of quantum physics.