PhD defence

A national survey conducted by Dutch newspapers Dagblad van het Noorden, Turbantia, Brabants Dagblad and the Dutch Federation of Trade Unions (FNV) shows that staff working in disability and mental health care often face violence in the workplace. In the three northern provinces of the Netherlands,…

The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…

Kros

An overview of the research at the Biologics Formulation group

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

We study the structure, dynamics and physics of complex networks emerging from the intricate interconnectedness of the constituents of large systems.

How do common marmosets combine their calls into sequences and how are their vocalisations influenced by reproductive state?

Human activity, such as pollution, may disturb the balance of living water systems, which has consequences for biodiversity, but also for other functions such as water purification. Leiden University maps living water systems using the most advanced technologies.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

Education & outreach

A full overview of MCBIM PhD theses.

Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…

The knowledge and skills you will acquire will qualify you for many different jobs. Possible careers include: researcher of learning, behavioural and emotional problems in children, or designer of prevention and intervention programmes.

How can we monitor and protect biological and cultural diversity in Suriname best? What can we learn from local knowledge and customs associated with biodiversity? How can we understand current species, acoustical, behavioural, and ecological diversity from an evolutionary perspective? Can we predict…

Inaugural lecture

Lecture, Research Seminar

Lecture, Histories Connected: Work-in-Progress

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

The aim of the RAISE study is to investigate how resilient people respond to stress. Specifically, we will study how key biological systems (HPA-axis, immune system) interact with the brain and social environment in order to facilitate resilient functioning after childhood adversities.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

What are the functions of the endocannabinoid system?

The studies reported in this thesis were situated in the context of an innovation of Dutch secondary school biology curricula. As in any innovation, the practical knowledge of teachers determine the outcomes through the decisions they make while planning and teaching their lessons. The aim of the studies…

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Some species of proteins which can form liquid-like condensates, also exhibit growth into fibers (or fibrils). One particularly interesting set of such proteins are those that are associated with neurodegeneration in which the fiber growth may be related to the pathological fibrils observed in disea…

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.

The Leiden Institute of Advanced Computer Science (LIACS) of Leiden University proudly establishes the Blaise Pascal chair. The chair applies for one year and is meant to strengthen the cooperation of the Leiden computer science research with foreign institutes.

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On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

Supervisor: P.J.J. Hooykaas

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Research projects

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.

The group is involved in training in areas of diagnostic skills, treatment/prevention/intervention, neuropsychological assessment, behavioral observations, clinical interviewing, knowledge of intellectual disability, autism, ADHD, psychosis and aggression.

Promotor: M. Ubbink, Co-promotor: G. Siegal

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

In the Drug Research theme, we primarily work with rodents. Rodents, such as mice, are one of the most common laboratory animals. These small mammals are easily housed and exhibit a rapid rate of reproduction.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands