A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

HZ Kenniscentrum Zeeuwse Samenleving doet op vraag van regionale overheden en maatschappelijke organisaties onderzoek naar actuele en maatschappelijke thema’s in de provincie Zeeland. De uitkomsten van onderzoeken en analyses worden gebruikt voor kennisopbouw en als basis voor beleidsopbouw en -ontwikkeling.…

Promotor: A.P. IJzerman

GoodBrother aims to increase the awareness of the ethical, legal, and privacy issues associated with audio- and video-based monitoring and to propose privacy-aware working solutions for assisted living.

Leraar worden in het voortgezet onderwijs? Bekijk dan deze video.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Inaugural lecture

How do games work? How do you make them? And how do games make us and our societies and cultures? The minor Game Studies will provide you with both the perspective and practice to give your own answers to these questions.

Policy studies and interventions in the field of Youth

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

How do classroom demonstration experiments help students learn chemical reasoning? Marie-Jetta den Otter, PhD student at ICLON, researched this. She defends her thesis on 6 December.

In the last weekend of April, the tenth edition of the Benelux Mathematics Olympiad took place. The Dutch delegation won a total of 8 medals. The 17-year-old Nils van de Berg even obtained a golden one!

In September, university lecturers Olga van Marion and Astrid Van Weyenberg started working as education coaches. How did their first semester of activities go and what is next on the horizon?

What practical knowledge do mentor teachers have of adaptive mentoring and of individual differences between student teachers?

To what extent are university teachers' individual learning paths influenced by their teaching experience, motivation, and conceptions of teaching and learning through educational technology?

The Department of Constitutional and Administrative Law of Leiden University is active in education in various ways.

Op deze pagina vind je de internationale universitaire netwerken waar de Faculteit der Rechtsgeleerdheid deel van uitmaakt.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

In this article, Yannick Veilleux-Lepage and Tommy van Steen, assistant professors at the Institute of Security and Global Affairs, discuss the degree of consensus within the field of terrorism studies regarding the impact of the COVID-19 pandemic on the activities of violent non-state actors.

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

As part of your assignment you are required to contribute to teaching in the Bachelor and the Master programs in Bio-Pharmaceutical Sciences of Leiden University. You will supervise Bachelor and Master students during the research projects of the students in the laboratory.

Members of our research team give different types of presentations and lectures.

Perfect for use at advanced undergraduate and graduate level, this is the first text to offer students a unified narrative regarding the place of the body in Western thinking. The book investigates the ways in which the fact of human embodiment makes the notion of ambiguity central to all major areas…

The PhD Committee is a bottom-up initiative that aims to create an open, active, and fun environment for all PhD candidates at Leiden University’s Faculty of Archaeology.

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

We investigate the physics and design of mechanical metamaterial, intricately sculpted materials with properties set by their architecture.

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

The core of Leiden University's vision is to train students to become academic professionals and engaged, responsible citizens. Once they have graduated, out students will then be able to make a contribution to resolving the challenges currently facing society - both within and outside academia.

Marietje Beemsterboer defended her thesis on 12 June 2018 (in Dutch)

An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…

Conference

Nematic liquid crystals form the key ingredients of most tv screens. The active version of these complex fluids forms a useful model for physicists to research the responses of active matter—like bacteria or traffic flows—to mechanical and geometrical cues. An international research team publishes their…

The Hague is the international city of peace and justice, home to many international organisations, embassies and multinational corporations but also a fun student city filled with music, cafes, museums and the most popular beach in the Netherlands!

The Hague is the international city of peace and justice, home to many international organisations, embassies and multinational corporations but also a fun student city filled with music, cafes, museums and the most popular beach in the Netherlands!

The Hague is the international city of peace and justice, home to many international organisations, embassies and multinational corporations but also a fun student city filled with music, cafes, museums and the most popular beach in the Netherlands!

This dissertation provides a grammatical description of Ghomara Berber, a Berber language spoken in North-West Morocco by about 10.000 people. The grammar consists of a description of the phonology, the morphology and the syntax. In the appendices a number of texts and a wordlist are included. The data…

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

The Hague is the international city of peace and justice, home to many international organisations, embassies and multinational corporations but also a fun student city filled with music, cafes, museums and the most popular beach in the Netherlands!

The Hague is the international city of peace and justice, home to many international organisations, embassies and multinational corporations but also a fun student city filled with music, cafes, museums and the most popular beach in the Netherlands!

The Hague is the international city of peace and justice, home to many international organisations, embassies and multinational corporations but also a fun student city filled with music, cafes, museums and the most popular beach in the Netherlands!

The Hague is the international city of peace and justice, home to many international organisations, embassies and multinational corporations but also a fun student city filled with music, cafes, museums and the most popular beach in the Netherlands.

How can I get students to collaborate more and increase their engagement? That was the question that teacher, and winner of the 2022 Faculty Teaching Award, Astrid Van Weyenberg asked herself two years ago. Her solution? A method in which the use of podcasts ensures that students actively engage with…

Education and Organisation Development

Last Tuesday 20 February, the first Public Administration Alumniactivity took place, with the theme: Citizen participation in theory and practice. Carola van Eijk talked about her PhD Research 'Engagement of citizens and public professors in the co-production of public services.' Menno Spaan, founder…

PhD defence