From 22 to 24 October, researchers of the MARBLES-project informed museum visitors about microbes: bacteria and fungi that live all around us. The event was organised around the Micro-day of Leiden, which is this year’s EU City of Science.

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

The image of the Leiden microboat traveled all over the world, from the BBC up to Arab shipping blogs. But Daniela Kraft's research group has quite a few more different 3D printed microswimmers up their sleeves. Kraft receives a Vidi research grant for research into these variously shaped active par…

Mazène Hochane and Xueying Fan have won the fourth annual LION Image Award. They created a detailed colour image of a human kidney in development.

Why do some bacteria lose their protective cell wall under the influence of stress? Microbiologist Dennis Claessen of the Institute of Biology Leiden receives a Vici grant of 1.5 million euros from the Dutch Research Council (NWO) to investigate this paradoxical feature.

He presented his PhD research entitled “Kick-starting drug development; translational systems pharmacology using innovative zebrafish experiments and advanced computational modelling”. During his presentation, Rob highlighted the advancements he made in using zebrafish as model in system pharmacolog…

Leiden University has appointed John van Noort as Professor in Biophysics. He studies the way in which our DNA is folded and read out.

The Dutch Research Council (NWO) has granted four grants to Leiden humanities scholars. They get to spend this money on research on a topic of their choice, without thematic preconditions.

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.

Provenance and distribution of raw materials

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

An overview of awards and prizes granted to our staff and students in 2019, as well as special appointments and royal distinctions.

Eleven Leiden researchers have been awarded an 800,000 euro Vidi grant by the Dutch Research Council (NWO). This will enable them to develop their own innovative line of research and start their own research group.

‘Working in Leiden is a dream come true.’ Ákos Kovács studied in his birth country Hungary and worked in Germany, Denmark and Groningen. As professor of Microbiome Ecology at IBL, he immediately started working together with his new colleagues to make discoveries about the versatile bacterial species…

Nanodiamonds and charcoal in Dutch soil provide no evidence for the alleged impact of a meteorite at the end of the last Ice Age. This is the conclusion of a research done by Utrecht University in collaboration with Leiden University and the University of Groningen.

Chinese universities have big ambitions to be among the leading international higher education institutions. What does this mean in terms of opportunities for researchers at the universities of Leiden, Delft and Rotterdam? Staff at the universities recently discussed the issue.

Biologists today have to be able to work with big data. Data analysis skills should be taught from the start of the degree programme, or - even better - in secondary school. This is the message of Vera van Noort, new Professor of Computational Biology. Inaugural lecture 22 January.

As of 1 June, Leiden University has appointed Sense Jan van der Molen as Professor Physics of Condensed matter. He investigates the unique electronic properties that arise when atomic thin layers are stacked on top of each other into new materials.

Manufacturers produce high-end technology mostly top-down with large machinery, but small particles are able to build structures by themselves from the bottom up. A major challenge is that these particles easily clump together. Leiden physicist Daniela Kraft has developed a method to use this phenomenon…

Mysterious protein fibers show up in the brain cells of people suffering from Alzheimer’s' disease and other neurodegenerative disorders. Leiden physicist Louise Jawerth has been awarded a Vidi grant to find out how these fibers form in the first place.

In the week of 22 May, a delegation of the Faculty of Science visited Indonesia to strengthen the cooperation with the Universitas Gadjah Mada, the Universitas Indonesia and the Kebun Raja (botanical garden) in Bogor. Furthermore, the delegation visited the faculty of Pharmacy of the Institut Teknologi…

Research into depression in children, Leiden alumni in the Dutch House of Representatives and an exceptional achievement by one of our students: what do this topics have in common? They are among our most read stories of 2021.

The bacterium Vibrio cholerae is a serious threat to our health because it is the causative agent of cholera. Worldwide, over a billion people per year are at risk of cholera infection. New strains of V. cholerae are resistant to the multiple drugs used to treat cholera, meaning that new types of drugs…

Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.

Making all those things we normally cannot see visible is the challenge that fascinates Fons Verbeek, Leiden's new Professor of Computational Bio-Imaging. Contributions from chemistry, optics and in particular computational sciences to making and processing these images give greater insight into the…

PhD student Wen Yang discovered how certain cell receptors in E. coli bacteria signal 'smells'. With the use of ice-cold electron microscopy microbiologists from Leiden gain more insight into how bacteria respond to their environment. Publication in mBio.

Physicists Lucia Bossoni and Martina Huber have been awarded an NWA Ideeëngenerator-grant for research into iron nanoparticles in the brain. These nanoparticles may be linked to air pollution and Alzheimer's disease.

Neanderthals in cold regions probably ate a lot more vegetable food than was previously thought. This is what archaeologist Robert Power has discovered based on new research on ancient Neanderthal dental plaque. PhD defence 1 November.

The €6.24 million EU-funded research project QSPainRelief has kicked off. The project aims to help patients suffering from chronic pain with novel, personalised combinational treatments and is coordinated by Elizabeth de Lange from the Leiden Academic Center for Drug Research.

On 27 February, 2019, Kampala International University (KIU) was the venue of the conference ‘Digital Health and Development in Data Science in Uganda’. Professor Mirjam van Reisen from the Leiden Centre of Data Science was one of the main speakers.

Lecture

How can you ensure that more experimental drugs reach the finish line? At the moment, only one in twenty cancer drugs that are tested on humans makes it to the market. This is an enormous loss for patients and society. With a grant from the National Growth Fund, Oncode-PACT aims to efficiently select…

Lecture

Catalysts are indispensable in everyday life. We know what they do and more or less how they do it, but we still lack a fundamental understanding about their functioning at an atomic scale. Therefore, Irene Groot from the Leiden Institute of Chemistry develops new measuring techniques to unravel the…

Joost Beltman (LACDR, Leiden University) has provided novel insights in the way T cells migrate towards virus-infected cells. This was accomplished by a combination of experimental research in the group of Ton Schumacher (Dutch Cancer Institute, NKI) and computer simulations in collaboration with Rob…

Good research means looking beyond disciplinary boundaries, said Professor of Molecular and Cellular Biochemistry Remus Dame in his inaugural lecture on 10 May. Processes that take place on DNA shouldn’t only be researched in a test tube but also in living cells, for instance.

Researchers need to work in specialized environments when they work with dangerous bacteria and viruses. These microbes spread easily, so only in labs with a high biosafety levels they can be studied. Unfortunately, to look at the microbes properly, expensive microscopes are needed that are not always…

For the first time ever, Leiden biologists have found that the ‘nose’ of spirochetes – worm-shaped bacteria – have a two-fold symmetry. A remarkable discovery, as the ‘nose’ of every other bacterium has been found to have a six-fold symmetry. First author Alise Muok wrote a popular blog about the findings…

A certain type of oil droplets changes shape when cooled and shrunk: from spherical through icosahedral to flat hexagonal. Two competing theories couldn't fully explain this, but now, a Physical Review Letter by Ireth García-Aguilar and Luca Giomi solves the mystery.

A flint tool covered with a tar-like substance has turned out to be a top scientific find. Research by a Dutch team of scientists showed the find to be a piece of birch tar that was extracted 50,000 years ago by Neanderthals using complex techniques. The tar was used as an adhesive to make it easier…

The European Research Council has awarded a Starting Grant to five early career scientists from Leiden University. They received funding up to 1.5 million euros to further expand on their research subject.

The cellular recycling system in zebrafish is capable of eating harmful bacteria and thus resist infections such as tuberculosis and salmonellosis. That is written by Leiden biologists from the group of Annemarie Meijer. Stimulating this form of defence could be used in new treatment methods against…

Leiden researchers found a way to measure the tiny forces exerted by pericytes, one of the most elusive, hard to research cell types, which occur in tiny blood vessels. Building on this fundamental science, researchers may eventually find treatments for medical conditions like ischaemia.

The annual LION Image award goes to the 30 micrometer long 3D printed microboat image that went viral earlier in October 2020, submitted by Rachel Doherty of the Daniela Kraft lab.

Confetti, stilt walkers and the new Einstein Fountain. On Monday, 2 September, the Gorlaeus Building of the Faculty of Science was festively opened. Together with Constantijn van Oranje, our students cut the ribbon. Dean Jasper Knoester: ‘The building is ready, now it is up to our students and researchers…

The European Commission has officially established Euro-BioImaging – which provides life scientists with open access to a broad range of technologies and resources in biological and biomedical imaging – as a European Research Infrastructure Consortium (ERIC). The Cell Observatory in Leiden is part of…

Gold nanoparticles give us a better understanding of enzymes and other molecules. Biswajit Pradhan, PhD candidate at the Leiden Institute of Physics, uses gold nanorods to study individual molecules that would be challenging to detect otherwise. Resulting knowledge can be applied to many research fields,…

Gerard van Westen has been appointed full Professor or Artificial Intelligence and Medicinal Chemistry. This chair has been jointly created by the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institute of Chemistry (LIC) as part of SAILS, the university stimulus program in Artificial…

Recently, NWO has decided to grant two interdisciplinary research proposals for national and international consortia submitted by researchers from the Institute of Biology Leiden. One of the proposals is led by Prof. dr. Ariane Briegel, the other one by dr. Remko Offringa.