369 search results for “metabolism” in the Public website
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Marc Baggelaar graduates cum laude on body’s own marijuana
PhD candidate Marc Baggelaar of the Leiden Institute of Chemistry (LIC) graduated cum laude on Thursday 6 April. His thesis on the endocannabinoid system in the brain is very comprehensive and of high quality, according to the jury. ‘A very talented young scientist, that definitely belongs to the top…
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Stans Prize for Kevin Groen
The ‘Stans Prize 2015' (for the best thesis, report or article produced by a CML student) has been awarded to Kevin Groen. Other CML prizes were awarded to Laura Bertola, Patrik Henriksson and Rene Kleijn.
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300 million euros for new international stem cell consortium
The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…
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How do we maintain a healthy biological clock?
During Seeing Stars Leiden all the lights around Leiden Observatory will be switched off for an hour. The more lights that go out, the more stars we’ll be able to see. For the LUMC, this is the perfect moment to think about our biological clock, the topic researchers from the BioClock consortium are…
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New measuring method facilitates drug research
Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.
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Three VICI grants for Leiden researchers
Three Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Scientific Research (NWO). They each receive 1.5 million Euro to develop their own research project in the coming 5 years.
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LDE minor focuses on resources needed for energy transition
European dependence on Russian gas, earthquake damage in Groningen and the changing climate: the call for an energy transition is getting louder. This transition will be accompanied by an increasing demand for 'new' raw materials. The Geo-Resources for the Future minor looks at exactly that developm…
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Interview with PhD student: Doris van Bergeijk
Leiden University is partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH interviewed Doris van Bergeijk: PhD student of the project…
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Towards a liveable future
Humans have influenced nature since as early as the Ice Age, and over the past century man’s impact has become even greater with our many new technologies and a growing world population. Leiden researchers study this impact and how we can keep it within reasonable limits so that nature can be preserved.…
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Hard chews: why mastication played a crucial role in evolution
We do it every day but barely give it a thought: chewing our food. But the ‘simple’ process of masticating food may have played a crucial role in the evolution of our jaws, facial muscles and teeth.
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Plastic nanoparticles make larval zebrafish hyperactive
Nanoplastics influence the behaviour of larval zebrafish, says new research by the Institute of Biology Leiden (IBL) and the Institute of Environmental Sciences (CML). The researchers observed that a certain type of nanoparticles leads to stress reactions in the sugar balance, resulting in hyperactivity…
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Veni grants for 19 young Leiden researchers
Nineteen researchers who have recently been awarded their PhD are to receive a Veni grant of up to 250,000 euros. Science funding agency NWO has awarded a total of 158 Venis in this round; Leiden University's share of the awards is 12 percent.
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Exploration of the endocannabinoid system using metabolomics
PhD defence
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
PhD defence
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Regulation of signal transduction pathways by hypoxia in breast cancer subtypes
PhD defence
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Better ligands for G Protein-Coupled Receptors
The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.
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POSTPONED: LIC Lecture
Lecture
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LED3 Lecture - Elucidating inositol pyrophosphate signaling with chemical tools
Lecture
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Targeting Inter-Organ Cross-Talk in Cardiometabolic Diseases
PhD defence
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The Netherlands-Brazil: 1-1
The Sport Data Center wants to unravel the secrets of Dutch and Brazilian football, together with a diverse group of partners. Furthermore, the consortium will in both countries measure the health risks that arise from being bound to a wheelchair.
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How a Spanish post-doc brings her expertise in chemistry to Leiden genetics
Having a bachelor's, a master's and a PhD in Chemistry, Elena Sánchez López shifted to a more biological field of research for her postdoc. She completed all her studies at the University of Alcala, in Spain, before applying for a LEaDing fellowship at Leiden University, a Marie Sklodowska-Curie Cofund…
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Predicting and preventing serious COVID-19 symptoms
Scientists in Leiden are looking for signals in blood samples to predict whether patients will develop serious COVID-19 symptoms or not. Based on that knowledge, they will be able to propose targeted therapies to prevent serious symptoms. They hope to come up with the first results within the week.
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LUMC will administer first Dutch stem cell gene therapy to patients
Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…
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Vidis for eleven Leiden researchers
Eleven talented Leiden researchers with several years of research experience have been awarded a Vidi subsidy to set up or expand their own line of research.
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Webb detects icy ingredients for making potential habitable worlds
An international team of astronomers, led by Will Rocha of Leiden Observatory, using the NASA/ESA/CSA James Webb Space Telescope have discovered that the key ingredients for making potentially habitable worlds are present in early-stage protostars, where planets have not yet formed.
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Making better use of our natural resources
The availability of natural resources, the energy transition, the importance of circularity and our dependence on China. This and more is what Professor of Industrial Ecology René Kleijn's inaugural lecture is about.
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Working with SBB Interns. By Roel Bulthuis of Merck Serono
Since 2008 every half a year an SBB student starts with an internship for Merck Serono Ventures in Geneva. Head of the company Roel Bulthuis selects and works with the SBB interns and shares his experiences as an employer. He is very pleased.
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‘Ask scientists how to build the circular economy’
Some governments and companies are pursuing a more circular economy, but what is the best way to get there? An international group of industrial ecology researchers wrote a report that stresses the importance of including the scientific side into policies and practices. ‘We feel an obligation to support…
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800 year old mystery of ancient bone disease solved
Scientific research at the molecular level on a collection of medieval skeletons from Norton Priory in Cheshire, United Kingdom, could help rewrite history after revealing they were affected by an unusual ancient form of the bone disorder, Paget’s disease. Osteoarchaeologist Carla Burrell, attached…
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New technique offers chemists unprecedented control in drug research
Leiden chemists have developed a new technique with which they can determine the role of kinases – a group of proteins – in a living cell. This technique makes it easier to find new drug targets for diseases such as cancer and rheumatoid arthritis. The team published the findings in the journal Nature…
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NWO grant for research facility into the impact of environmental factors on health
What is the influence of non-hereditary factors on our health, such as lifestyle, diet and exposure to harmful substances? The Exposome-Scan project, led by Leiden professor Thomas Hankemeier, has been awarded 3.2 million euros from the NWO Investment Grant Large programme to answer this question. With…
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Paradigm-shifting theory highlights the importance of substrate flexibility in enzymatic reactions
Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…
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Best Spanish doctoral thesis in Soil science in 2015 for CML researcher Daniel Arenas Lago
The Spanish Society of Soil Science has chosen as the best thesis of 2015 (call 2016) in Spain to the CML-researcher Daniel Arenas Lago, for his research at the University of Vigo that expands and deepens in new knowledge about adsorption and retention of heavy metals in soils, an issue increasingly…
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NEXUS1492 study on ancient human microbiomes published in Nature Scientific Reports
An international team of researchers, involving members from the ERC Synergy project NEXUS 1492 based at the Leiden University, the Universities of Oklahoma, Copenhagen and York reveal challenges when studying ancient microbiomes in a recent issue of Scientific Reports.
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Awards for three Leiden Partnership projects with industry sector
NWO is funding three partnership projects with the industry sector. The projects relate to speeding up the search for new medicines, studying the changes in proteins as medicine and developing analytical techniques for research on the building blocks of life.
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Hoe meer tijd, hoe beter de nier
Donororganen zijn er nooit genoeg. De organen die wel beschikbaar zijn, moeten vliegensvlug getransplanteerd worden. De geneeskunde zet daarom volop in op het langer goedhouden van organen. Marlon de Haan (24) onderzoekt hoe je nieren buiten het lichaam in leven kunt houden.
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Using low sample volumes to better understand brain diseases
Marlien van Mever delved into the analysis of tiny samples, cerebrospinal fluid from transgenic mouse models for example. She validated methods that can now be used to study brain diseases such as migraine and epilepsy. Van Mever will receive her PhD on 14 June.
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Three LUF grants for talented Leiden Science researchers
Fighting against cancer, antibiotic resistance and disposable plastics: Ahmed Ali, Fredj Ben Bdira, and Valerio Barbarossa receive a LUF grant for their innovative and socially relevant research. These grants for academic talent are often an important step towards grants by NWO and other grant insti…
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Faculty of Science opens academic year with live stream in homely setting
From a white leather armchair, on which Barack Obama once sat, Dean Michiel Kreutzer opened the academic year. This time not with visitors, but completely corona-proof via a live stream. In a homely setting, Kreutzer spoke with several guests, including Covid-19 researcher Thomas Hankemeier and brand…
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Profiling programme about body’s own marijuana brings institutes together
Bringing together institutes and research groups, how do you do that? The Faculty of Science set up a joint research theme and financed three PhD positions. After four years, the profiling programme Endocannabinoids expires. ‘It really brought us together, and the collaborations remain.’
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Leiden research projects awarded NWO Open Competition grants
Six researchers from Leiden University have been awarded NWO Open Competition funding.
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How nature boosts the health of city residents
Your local city park may be improving your health, according to a new paper led by Leiden environmental scientist Roy Remme. In Proceedings of the National Academy of Sciences Remme and his colleagues describe how access to nature increases people’s physical activity—and therefore overall health—in…
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Seven Leiden professors elected new members of KNAW
Seven Leiden professors have been elected as members of the Royal Netherlands Academy of Arts and Sciences (KNAW). In total 23 new members will be inaugurated on Monday 13 September.
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Difficult message for policymakers from two Leiden reports on circular economy
You should start working now, and the positive results will only be seen long after your term has expired. That is just about the worst thing you can say to politicians and policymakers. Yet that is exactly the message of two recent reports on sustainable resource use from the Centre for Environmental…
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Stiffness and viscosity of cells differ in cancer and other diseases
During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.
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Diversity of glucocorticoid signaling
PhD defence
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LED3 Lecture: Deciphering the Human Gut Microbiome with Chemistry
Lecture
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‘Like Don Quichot, you have to keep dreaming’
Having a bachelor, master and Ph.D in chemistry, Elena Sánchez López shifted to a more biological research for her postdoc. All of her studies she did at the University of Alcala, in Spain. Way back in medieval times, this city was the place of birth of Miguel de Cervantes, author of the world famous…
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Veni awards for seventeen young Leiden researches
The Netherlands Organisation for Scientific Research (NWO) has awarded Veni funding to seventeen researchers who recently obtained their PhD. This award offers promising young scientists the opportunity to develop their own ideas over a period of three years.
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Here’s to the next 443 years as a bastion of freedom
‘Praesidium Libertatis is a daily responsibility.’ These were the words of Rector Magnificus Carel Stolker on 8 February during the 443rd Dies Natalis of Leiden University. The University needs to pay continuous attention to open debate if it wants to remain a bastion of freedom.