Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)

The Leiden University Medical Center (LUMC) will start construction this year of the largest non-profit stem cell and gene therapy facility in the Netherlands, and one of the largest facilities in Europe. NECSTGEN – the Netherlands Center for the Clinical Advancement of Stem Cell and Gene Therapies…

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

PhD defence

PhD defence

PhD defence

PhD defence

Promotor: S.M. Verduyn Lunel

A multi-disciplinary approach to past lifestyles and cultural practices

How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.

Migraine is a brain disease. If it were simple, we would have solved it already'. That is the title of the inaugural lecture delivered by Professor of Neurology Gisela Terwindt on Friday 3 June. In her speech she emphasises the importance of research into the differences between women and men with m…

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

How do mycobacteria subvert the defenses of host immune cells?

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

What is the function of the insect serosa?

Can birds - like people- ‘see’ voices and learn how to sing by listening and watching?

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

Can drug screening for tuberculosis treatment be made more efficient?

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…

PHM offers you the tools to navigate through, and give direction to, the complex and changing health care landscape by using an interdisciplinary approach. Become the broker to improve health and societal outcomes for citizens and patients.

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

Early treatment benefits patients who have not fully developed rheumatoid arthritis but are in the preliminary stages of the disease. This is what researchers from the Leiden University Medical Centre (LUMC) have reported in The Lancet. Patients in the pre-arthritis stage who were temporarily prescribed…

The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…

The Faculty of Science

If you follow the western media, you are likely to think of ‘Africa’ as the continent of origin of desperate migrants, a continent of hunger and disease and a breeding ground for international terrorism. But if you want to see the bigger picture, you should look no further than the African Studies scholars…

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…

Mathematical biologists from Leiden have developed a model that helps to explain how the spine and vertebrae, among other things, form during embryonic development. The same process, the other way around, plays a key role in cancer metastasis. Publication in iScience.

Finally we know for sure that there is a black hole at the centre of our own galaxy. Today, astronomers unveiled the first ever photo of Sagittarius A*, a super-massive object at the centre of the Milky Way. This picture could only be taken thanks to the cooperation of telescopes worldwide.

In 2022, Leiden will be the European City of Science. During this year, Leiden will be the European stage for knowledge, with a programme filled with science, art and culture. Of course, the humanities also take part. Get to know the core team of our faculty.

We examine how soil inoculation influences aboveground organisms (i) directly, and indirectly via (ii) its effects on plant chemistry or volatile emission, or via (iii) mediating the effects of belowground pathogens on aboveground organisms via the shared plant.

Which immune mechanisms are involved in host defense against Staphylococcal infection?

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

The modification of risk factors and related health behaviors lies at the very core of adequate cardiovascular risk management, yet evidence shows that the majority of people with cardiovascular disease (CVD) fail to achieve a healthy lifestyle in the long term. The main objective of this project is…

Professors Simcha Jong (Leiden University) and Rifat Atun (Harvard University) convened an exploratory seminar to discuss challenges for health systems in realising the potential of precision medicine at Harvard University’s Radcliffe Institute for Advanced Studies in Cambridge, MA on 17 April 2017.

PhD defence

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

Mazatec chants and ancient Mesoamerican pictography

It is sufficiently plausible that the professor from the Faculty of Archaeology exhibited the ‘inappropriate and unacceptable behaviour’ detailed in the advice of the investigating committee. That is is unless the professor provides counter-evidence. This is the conclusion of the Subdistrict Court…