At the division of BioTherapeutics, Amanda Foks, Bram Slütter and Ilze Bot have obtained a €4 million research grant from the HORIZON 2022 EIC Pathfinder Challenge “Cardiogenomics”, entitled “B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD”.

On Monday 28 November 2016, Ton Liefaard spoke at the International Conference on Crime Prevention and Resocialization of Children in Contact with the Criminal Justice System in Chile. In his lecture he discussed European perspectives on crime and prevention and reintegration.

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

What should policymakers and politicians do to prevent violent extremism? What are the greatest risks posed by the radical left and right? How do ideological media publications that terrorists assemble before attacks, may help to counter extremist narratives? About 30 professionals from all over the…

What is the role of auxin in the initiation and process of somatic embryogenesis?

Leiden University and the city of The Hague are working closely together to increase the impact of our research and education in order to contribute as much as possible to the development of the city.

How can zebrafish research help understanding human diseases?

As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.

The doors of the new Gorlaeus Building are officially open! With an additional lab wing, new lecture halls and offices, a library, a brasserie, and spaces for student associations, the building offers a vibrant and inspiring environment for research, study, and social interaction. Explore on your…

Master's students of Vitality & Ageing work together with older individuals in the so-called ‘Living Lab’ to combat loneliness. You can watch four brief video’s that show their creative solutions for the course ‘the older individual’ that is coordinated by health psychologist Sandra van Dijk and former…

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Uncover novel antimicrobials with prospective health benefits for sea turtles.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…

The Sanquin blood bank gathers data on every donation. Around 720,000 donations are made every year. ‘That generates a mountain of highly valuable data,’ says Leiden PhD candidate Marieke Vinkenoog.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?

On Wednesday 25 January, the British Embassy, the Global Transformations and Governance Challenges (GTGC) programme at Leiden University and Women in International Security Netherlands (WIIS-NL) were hosting a round table with Professor Bina D’Costa to discuss the prevention of conflict related sexual…

The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…

An international team of scientists, including Xander Tielens of Leiden Observatory, has used space telescope Hubble and the ALMA observatory to show that UV radiation from massive stars can prevent planets from forming. The researchers publish their findings on 1 March in the journal Science.

Leiden University, the LUMC and Janssen have signed a partnership agreement stating that they will collaborate in different areas, including infectious disease prevention, clinical tests, drug production and e-health. By joining forces, the three partners will be able to provide better, more innovative…

Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.

On 2 and 3 October 2017, a delegation of the Child Law Department has participated in the 15th European regional conference of the International Society for the Prevention of Child Abuse and Neglect in The Hague.

On January 24 Professor Annemarie Meijer and Dr Sander Wezenberg received a NWO grant for their research. The grant was awarded within the Open Competition Domaine Science-M programme and is intended for innovative research areas that can form the basis for the research themes of the future.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Pharmacologist Amanda Foks is one of the ten talented scientists who received a Dekker grant from the Hartstichting. She receives €427,000 to find a way to rejuvenate immune cells to prevent infarcts. Foks was nominated as Discoverer of the Year in 2016.

Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

Mensen jarenlang opsluiten in een gevangenis werkt niet en kost de samenleving veel geld, zeggen experts. Hoogleraar Criminologie en Vergelijkende Penologie Miranda Boone stelt tegenover NEMO Kennislink dat het anders moet: ‘Het strafrecht zoals we het nu inzetten, werkt niet.’

Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?

Which plant leaf characteristics are involved in thrips resistance in tomato?

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Heart failure is a major health care problem with high mortality.

The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Source: Mol Psychiatry (2015)

The Social Resilience & Security interdisciplinary programme broadens its scope by embedding two research projects lead by Dr. Joanne Mouthaan. The projects adress suicide prevention skills and mental health of Ukraine refugees. Both projects will be integrated in the programme with the aim to improve…

Edwin Bakker is one of the speakers during the