2,451 search results for “cell chemistry” in the Public website
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Madeline Kavanagh
Science
m.e.kavanagh@lic.leidenuniv.nl | +31 71 527 3527
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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Saloni Saxena
Science
s.saxena@biology.leidenuniv.nl | +31 71 527 4950
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Photographs & Preservation. How to save Photographic Artwork for the Future?
How can we understand the material instability of photographic (mixed media) artworks (1960s - present) from an integrated approach of Art History, Conservation Science and Chemistry in order to preserve these works for the future?
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Programme structure
The Drug Discovery and Safety specialisation consists of compulsory and optional components.
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Research
Research at the SBC group is comprised of the following research themes:
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Dr. Dong Guo won the Dutch Medicinal Chemistry prize 2013-2014
On March 27th, 2015 the biannual Dutch Medicinal Chemistry Prize for the best Dutch Ph.D. thesis in the field was awarded to Dr. Dong Guo, a current postdoc researcher in our lab, by the Section of Medicinal Chemistry of the Royal Netherlands Chemical Society.
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Chemistry can change the ingredients in planet formation
Which molecules go into forming planets? PhD candidate Christian Eistrup and his colleagues have created new models to research this question. Their findings could change our idea of which molecules were forming Jupiter or even Earth.
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Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
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Projects
Research projects
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.
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Holland Research School of Molecular Chemistry awards PhD project to David Klein
Leiden based chemistry student and chess grandmaster proposes molecular system for development of artificial leaf
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Master Projects
Master projects are available in
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Our people
Some examples of AI-research done at Leiden.
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Drug Discovery and Safety (MSc)
The master's specialisation Drug Discovery and Safety at Leiden University provides students with research-oriented education into the discovery of new drug targets and new lead molecules, particularly in the field of cancer, through a combination of advanced imaging techniques (‘systems microscopy’),…
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About the programme
Drug Discovery and Safety consists of 120 European Credit Transfer System (EC) points.
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Correcting each other’s mistakes - why cells stuck together in early evolution
The transition from single cells to multicellular organisms was a key step in evolution. Researchers from Leiden and Amsterdam developed a mathematical model that explains how this transition may have come about. They suspect cooperating cells may correct each other’s mistakes. Publication in eLife…
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‘How can we translate the language of cells into cancer therapies?’
On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…
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Inexhaustible source of human heart muscle cells allows strong reduction of animal testing
Researchers at the Leiden University Medical Centre (LUMC) have managed to culture human heart muscle cells on a massive scale. This is an exceptional achievement because it is very difficult to replicate heart muscle cells outside the body. Using a special technique, the researchers have now created…
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TARGETBIO: Transmission of Antimicrobial Resistance Genes and Engineered DNA from Transgenic Biosystems in Nature
This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.
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Former Chemistry PhD student Tiddo Mooibroek nominated for New Scientist Talent prize
Former Chemistry PhD student Tiddo Mooibroek is one of the 25 nominees for the title New Scientist Science Talent 2017. Nobel prize winner Ben Feringa will announce the winner at the New Scientist Live: Nobelprijs event on June 22, after a rating of the candidates by a jury and a public vote.
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appointed as full Professor of Artificial Intelligence and Medicinal Chemistry
Gerard van Westen has been appointed full Professor or Artificial Intelligence and Medicinal Chemistry. This chair has been jointly created by the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institute of Chemistry (LIC) as part of SAILS, the university stimulus program in Artificial…
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Stiffness and viscosity of cells differ in cancer and other diseases
During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.
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CD11b+Gr-1+ myeloid-derived suppressor cells reduce atherosclerotic lesion development in LDLr deficient mi
Publication by: Amanda Foks, Gijs van Puijvelde, Jolien Wolbert, Mara Kröner, Vanessa Frodermann, Thomas van der Heijden, Peter van Santbrink, Louis Boon, Ilze Bot and Johan Kuiper. Cardiovascular Research. 2016;111(3):252-261.
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T-cells more important in the fight against the COVID-19 virus than initially thought
A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…
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LUMC will administer first Dutch stem cell gene therapy to patients
Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…
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Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…
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Osteosarcoma: searching for new treatment options
Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen
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Research
Research at the BIOSYN group is comprised of the following research themes:
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Fundamental Research in Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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Miraculous mechanism allows plant cells to directionally distribute the growth hormone auxin
Leiden and Austrian researchers have succeeded in further uncovering how a plant cell passes on the growth hormone auxin in a directional manner to the next cell. Three proteins that cling together in a bunch appear to be essential for this important transport process. ‘This discovery solves a crucial…
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Chara
The Green algae Chara as model system for intra and inter cellular transport processes.
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Regulators of integrin α6β4 function
This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.
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From chemistry teacher to founder of outdoor escape room company
Alumnus Vincent Renken studied Bio-Pharmaceutical Sciences in Leiden and is now co-founder of an outdoor escape room company. ‘I asked myself: do you want a standard life or an adventure?’
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A unique defence: Bacteria lose cell wall in the presence of virus
Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…
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First patient in the Netherlands successfully treated with stem cell gene therapy
Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…
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Ewine van Dishoeck receives ERC Advanced Grant for research into the chemistry of new worlds
Leiden Professor of Molecular astrophysics Ewine van Dishoeck has been awarded an Advanced Grant by the European Research Council (ERC). She has been awarded 2.3 million euros in research funding for the MOLDISK programme. Within this programme, Van Dishoeck wants to connect chemistry and physics in…
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Microbial Sciences
In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.
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Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
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It’s all about the cell wall for brand-new professor Dennis Claessen
Dennis Claessen has been appointed professor of Molecular Microbiology at the Institute of Biology Leiden. With his teaching and research on the cell wall, the professor wants to establish applications in the industry and the medical sector.
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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An overall picture: the environmental impacts of a new solar cell technology
A more efficient solar panel sounds great. But what if these new panels consume more toxic materials, or their production consumes a lot of energy? Leiden environmental scientists, together with colleagues from the Fraunhofer ISE, address this multifaceted question in a new publication in the prestigious…
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Activity-Based Proteasome Profiling
Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea
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Research
Research at the BPOC/SSNMR group is comprised of the following research themes:
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The power of one qubit in quantum simulation algorithms
Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…
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In memoriam Harold V.J. Linnartz 1965 – 2023: Unlocking the Chemistry of the Heavens
With great sadness we share the news that Prof. Harold Linnartz passed away suddenly and unexpectedly on Sunday 31 December 2023. We are all in shock, and our thoughts are with his wife and children, other family, and friends. Harold was at the heart of our institute, as a researcher, as a supervisor,…
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar
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Nanomedicine to Visualize and Treat Inflammation after Stroke (NAVISTROKE)
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