The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.

Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Promotor: Prof.dr. J. den Hertog

An assessment approach that tailors to children’s instructional needs

Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.

We know from national and international research that many students struggle with psychological problems. How about students in Leiden? Leiden University's Student Well-being Taskforce wants to see more research and has also come up with some advice, ranging from personal buddies and digital support…

Positive friendships are characterised by understanding mutual wishes and intentions, respect for each other’s boundaries and pro-social behaviour. Qualities that might be more challenging for autistic adolescents.

In a longitudinal study, Eichengreen and colleagues explored how the certain aspects of emotional intelligence impact the development of adolescents’ mental health, thus identifying potential warning signs and targets for intervention programs. Despite a higher risk for mental health issues and lesser…

PhD defence

We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…

This study aims to answer two main research questions: (1) What are the main predictors of work ability in employees with migraine? (2) Can we optimise work ability in employees with migraine using a web-based intervention focused on these relevant predictors?

How do people acquire language? How can you train your brain? What is the effect of stress on an unborn child? LIBC research topics range from language processing to cognitive robotics, and from psychiatric disorders to the impact of social factors on human behaviour. Meet several main research topics…

Deep-brain stimulation (DBS) is the most promising surgical treatment for movement and neuropsychiatric disorders, but is accompanied by unwanted side effects. Birte Forstmann, professor by special appointment, has been awarded a ERC Proof of Concept Grant to create an atlas of the human deep brain…

Learning about circadian rhythms can help students to improve their sleep and overall well-being

AI MAPS adopts a freedom and social well-being perspective and focuses on three themes to address key security challenges; Social disorder and public nuisances in neighbourhoods, High-impact crime, and Crowds and events.

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…

PhD defence

PhD defence

PhD defence

‘Equal opportunities for diverse young people’ receives a Starting Incentive of the Natonal Science Agenda of 2,5 million euros. In this project research is conducted on the processes and mechanisms in the changing environments in which young people grow up that contribute to equal - or unequal - opportunities.…

'With this artwork, I want to give the audience a glance into my overstimulated brain and that of other people with autism', says Jasmijn den Hoed. The Faculty of Social and Behavioural Sciences is exhibiting her artwork 'Overstimulated' in the restaurant near the blue wall during Autism Week 25 March…

The study adviser (or coordinator) is an expert on all aspects of the Media Technology MSc program. If you have any questions or concerns about your studies, whether they be of a practical or academic nature, you can contact your study adviser.

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

The research master's specialisation Clinical and Health Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.

Psychologist Myrthe Jansen conducted research into the performance monitoring that constantly takes place in our heads. People with obsessive-compulsive symptoms are more afraid to make a mistake that harms others, than when they make a mistake that only harms themselves. Jansen received her PhD on…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Ten Leiden social and behavioural scientists have successfully applied for the NWO Open Competition. With this Open Competition, NWO gives researchers the chance to start small, high-risk, innovative or promising research projects.

Boys with autism are more prone to develop physical complaints, depression and aggressive behaviour. Psychologists at Leiden University have discovered that this is mainly related to rumination. Publication in the Journal of Autism and Developmental Disorders.

Development and validation of instruments that can measure different aspects of emotional competence in children with normal and atypical development, and in different cultures

Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.

As of 1 August, Anika Bexkens has been appointed Professor of Evidence-Based Clinical Practice for Child and Adolescent Mental Health. Her research focuses on the optimal application of scientific knowledge in practice. ‘Scientists and practitioners often speak past each other.’

You can find some tips here on how to maintain your mental health.

It’s Not Easy Being Green – but we’re here to help! Do you want to live more sustainably but have no idea where to start? Are you interested in making the world greener and do you want to get to the bottom of hot topics? Or are you sceptical about climate change and do you want to hear about the…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

This research cluster centres on regional, national, and global intersections between a variety of artistic and cultural expressions and their role in society from 1800 onwards.

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…

The research connected to this topic is related to Work and health.

Retrospection over the last 40 years the most important changes in care and research, where transparency accountability and guidelines became leading. On Huntington’s disease and cerebrovascular disorders the most important changes are illustrated.

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

PhD at the Natural Product Laboratory, Institute of Biology, Leiden University - the Netherlands

Psychologists of Leiden University and Peking University will collaborate to investigate the deficiencies in emotion recognition in children with Autism Spectrum Disorder (ASD). The new collaboration fits very well in the policy of Leiden University in which intensified collaboration with China has…

The research team