Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…

RARE-NL, a new collaboration between university hospitals, hopes to find treatments for rare diseases. Professor Teun van Gelder is representing the LUMC in the initiative.

As part of the HTSM2017 funding program, the LACDR division for Systems Biomedicine and Pharmacology received 1.08 million euros for a research project to develop novel engineering approaches to fight cancer.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

The Cyber Security lecturers are scholars and lecturers of Leiden University, Delft University of Technology and The Hague University of Applied Sciences.

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

Squatters and autonomous movements have been in the forefront of radical politics in Europe for nearly a half-century—from struggles against urban renewal and gentrification, to large-scale peace and environmental campaigns, to spearheading the antiausterity protests sweeping the continent.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Promotor: A. Kros

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…

Chronic pain, nausea or vomiting due to chemotherapy. If you suffer from such ailments, medicinal cannabis can be a godsend. Though a downside is that it can make patients high. Therefore, Leiden researchers from the Oncode Institute are investigating alternatives that do not make you high. In Nature…

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Edith Schippers, Minister of Health, will be investing six million euros over the coming four years to boost research on new antibiotics. The programme will be set up by several different parties, including the Leiden Centre for Antimicrobial Research.

Getting personal

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine and Pharmacology, and the Metabolomics and Analytics Centre.

Research lines within the Pharmacy group:

Lecture

Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…

Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?

The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.

Our research programme collaborates with all kinds of partners to achieve our goal: bringing scientific discoveries to the clinic as soon as possible.

Fascinated by science since high school, Alireza Mashaghi Tabari is driven to explore new ways of thinking in medicine. With a strong academic network, he educates students and gives public lectures. For his research at LACDR, he won the C.J. Kok Public Award 2018, making him the Faculty of Science's…

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

An overview of research projects at the Predictive Pharmacology group.

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…

In the Research in Bio-Pharmaceutical Sciences specialisation you will perform research on various topics in the area of Drug Discovery and Development. The programme offers a high level of flexibility and can be tailored to your scientific interests. The major research project is hosted by the Leiden…

In the Phenomix Medical Delta Field Lab, which was officially opened on Thursday 9 July, scientists, healthcare institutions and businesses work together to develop innovative applications in the field of metabolomics. This research field makes it possible to determine which drugs will be effective…

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Lecture

What is the best method and time to test the effectiveness of medicines? PhD student Rob van Wijk of the Leiden Academic Centre for Drug Research (LACDR) discovered zebrafish larvae are best used in drug research when they are five days old. His findings were published on 15 February in the journal…

An overview of the research at the Biologics Formulation group

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

The focus of the Antiviral Pharmacology group led by Anne-Grete Märtson is optimizing antiviral therapy for different viral infections by conducting clinical trials and using innovative computational and dynamic laboratory methodologies.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We are moreover strongly involved in the Master specialisation of Pharmacy at Leiden University. We work on clinical problems that require further mechanistic understanding and…

In the Master’s programme Research in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.

In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.