Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

Promotor: G.P. van Wezel

The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

How does FoxP1 affect auditory perception on a behavioural and genomic level?

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Promotor: Prof.dr. J. Memelink

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Symposium

In the History of the Roman Emperors, what does Herodian’s method of composition consist of and how does it relate to his writing intention, particularly in terms of political and moral idea(l)s?

Beyond Boundaries: Religion, Region, Language and the State is a major multidisciplinary research project which aims to re-vision the history of Asia in one of its most significant periods. The project is based at the British Museum, British Library and the School of Oriental and African Studies, and…

This project is a close and sensitive contextual study of Jacob of Sarug's (ca. 451-521 AD) metrical homily

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

Damjan Donev is a PhD student in the ERC granted research project 'An Empire of 2000 Cities: urban networks and economic integration in the Roman empire', directed by Luuk De Ligt and John Bintliff (Archaeology).

The one-year (60 EC) master in Classics and Ancient Civilizations provides intensive and comprehensive training covering the entire range of present-day research on the ancient civilizations of Greece and Rome and the Ancient Near East.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

Leiden Center for the Study of Ancient Arabia

The MA Classics and Ancient Civilizations covers one year and can be studied in four tracks: Classics is one of them. While diving into the literary, cultural and intellectual worlds of Greece and Rome, you will be involved in current research, and stimulated to reflect on the significance of Classics…

The Classics and Ancient Civilizations programme offers many extracurricular opportunities to enrich your study experience.

The Classics and Ancient Civilizations (Research) programme offers many extracurricular opportunities to enrich your study experience.

The Classics and Ancient Civilizations programme offers many extracurricular opportunities to enrich your study experience.

The Classics and Ancient Civilizations programme in Egyptology offers many extracurricular opportunities to enrich your study experience.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”

PhD defence

PhD defence

PhD defence

This project examines the intriguing relationship between Greek literary criticism and Latin literature in Rome (first centuries BC and AD).

Lecture, Ancient History (UMW) Research Seminar and Ancient Worlds Network Lecture

The Classics and Ancient Civilizations (Research) programme in Egyptology offers many extracurricular opportunities to enrich your study experience.

The Classics and Ancient Civilizations (Research) programme offers many extracurricular opportunities to enrich your study experience.

The Classics and Ancient Civilizations programme offers many extracurricular opportunities to enrich your study experience.

The Classics and Ancient Civilizations programme in Assyriology offers many extracurricular opportunities to enrich your study experience.

The Classics and Ancient Civilizations (Research) programme in Assyriology offers many extracurricular opportunities to enrich your study experience.

This dissertation is concerned with the study of the less than twenty remaining precolonial Mesoamerican codices. By considering these rare and fragile pictographic and hieroglyphic books from the cultural biography perspective, many different aspects of these books can be studied.

This subproject of 'From Homo Economicus to Political Animal' analyzes Greek economic thinking of the Hellenistic period.

Classics and Ancient Civilizations (Research) covers two years and can be studied in four programmes, one of them is the Assyriology (Research) programme. When you choose to study Assyriology, you will both be guided through the broadness of Assyriological sub-disciplines, as well as gradually led to…

The Ra’s al-jinz project tackles economic diversification and social complexity in non-urban societies, from the perspective of Eastern Arabia, by exploring the Early Bronze Age settlement of Ra’s al-jinz RJ-3.