868 search results for “acoustic signal” in the Public website
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Grants & Awards
Grants awarded to molecular physiology research
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Towards High Performance and Efficient Brain Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…
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Yes/no question-marking in Italian dialects - A typological, theoretical and experimental approach
This dissertation provides an account of polar questions in Italian dialects from a typological, theoretical and empirical perspective.
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Unraveling cross-presentation pathways using a chemical biology approach
Is it possible for sugar patterns on cells to activate the immune system to combat cancer?
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Caught off guard? Evaluating how external experts in Germany warned about Russia’s war on Ukraine
This article reviews how external expertise supports intelligence production and crisis decision-making with Germany's response to the Russio-Ukrainian war.
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The role of 14-3-3 proteins in ion homeostasis in the yeast Saccharomyces cerevisiae
We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.
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A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Painting with starlight : optical techniques for the high-contrast imaging of exoplanets
This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.
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Drug Discovery & Safety
In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
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Individual and Contextual Sources of (Mis)Perceptions About the Impact of Immigration on the Welfare State
In this article, Samir Negash, PhD candidate at the Institute of Public Administratation, discusses the discrepancy in European countries between the measured impact of immigration on the welfare state and how this impact is perceived by citizens.
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The Teacher’s Invisible Hand: A Meta-Analysis of the Relevance of Teacher–Student Relationship Quality for Peer Relationships and the Contribution
Social relationships of students are important. Especially for students with problem behavior. How can a teacher support students in their social relationships via their own interactions with students? A lot, as is shown by a meta-analyses of Hinke Endedijk. She assessed almost 300 studies about teacher-student…
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Beyond UN75: A Roadmap for Inclusive, Networked & Effective Global Governance
Drawing on insights from past and contemporary scholars and world leaders, the report explores the concepts of a new social contract, a new global deal, and networked and inclusive multilateralism introduced recently by Secretary-General António Guterres to help the United Nations better grapple with…
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Cryo-EM of cholera infection
The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?
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Development of innovative engineered models for viral diseases
A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…
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Michel Orrit Lab - Single Molecule Optics
Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Grant: Dr. Amanda Foks receives a prestigious Junior Postdoc fellowship from the Dr. E. Dekker stipendium awarded by the Dutch Heart Foundation
Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.
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Molecular, Cellular and Organismal Biology (MSc)
The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.
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OFAC, Famine, and the Sanctioning of Afghanistan: A Catastrophic Policy Success
Matthew Hoye argues for a regulatory analytical perspective to look at the sanctioning of Afghanistan.
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Sentiment Shifts and a New Approach to Strategic Narratives Analysis: Russian Rhetoric on Ukraine
This article assesses Russian rhetoric toward Ukraine from 2004 to 2019 by analyzing statements by the Russian Ministry of Foreign Affairs.
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Deciphering myeloid (progenitor) cell function and communication in (tumor) tissues
PhD defence
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What does the city sound like?
How can we improve the everyday sounds of the city? In his inaugural lecture on 28 November Marcel Cobussen, Professor of Auditory Culture, advocates using the expertise of sound artists to raise the quality of acoustic environments in cities.
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The first of April was the official start of Phase II of the collaborative “PCAD4Cod”-project on the effect of sound on fish populations.
The first of April was the official start of Phase II of the collaborative “PCAD4Cod”-project on the effect of sound on fish populations. Hans Slabbekoorn, associate professor at the IBL, is the principal investigator and collaborates with three PhD-students, Dr. Erwin Winter, (Wageningen Marine Research),…
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Changing soundscapes
Hans Slabbekoorn, researcher at the Institute of Biology Leiden, is from the 16th to the 26th of July on board of the Pelagia, the Dutch national sea research vessel, which is currently on a collaborative mission for the National Initiative Changing Oceans (NICO). Slabbekoorn will study the effects…
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Female birds sing more often than previously thought
IBL-researcher Katharina Riebel, together with international collaborators, published a remarkable finding in Nature Communications on the prevalence of female birdsong.
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Hans Slabbekoorn receives NWA grant to study fish around wind farms in the North Sea
The Dutch Research Council (NWO) awarded behavioural biologist Hans Slabbekoorn (Institute of Biology Leiden) a grant of 750,000 euros to study fish and sounds around wind farms in the North Sea.
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Attentional processing of itch and pain
This project is aimed at 1) elucidating the role of attention in itch and pain, including orientation, and attentional disengagement (i.e., directing attention away) from itch and pain; and 2) modifiability of these attentional processes.
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Glucocorticoids in zebrafish
A novel in vivo model system for studies on glucocorticoid resistance
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Temperature effects on genetic and physiological regulation of adaptive plasticity
Promotor: P.M. Brakefield
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Inverse Agonism and Constitutive Activity
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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Packaging and accessing DNA molecules
Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.
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The Rocky Road from Experience to Expression of Emotions—Women’s Anger About Sexism
Sasse, van Breen, Spears & Gordijn demonstrated an anger gap in response to sexism which was larger for women than for men and found evidence that expressed anger was associated with instrumental concerns.
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Microbial Induction of Plant Resilience to Drought Stress (MicroRes)
What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?
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Ariane Briegel: 'AI literally opens new worlds for the life sciences'
Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’
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Metabolomics and Analytics Centre
The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…
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Two temperate Earth-mass planet candidates around Teegarden’s Star
Leiden University has participated in an international study carried out by the CARMENES consortium, which has discovered two small, terrestrial planets around Teegarden’s Star. The planets have masses similar to Earth and their temperatures could be mild enough to sustain liquid water on their surf…
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The Acquisition of Personal Pronouns in Cochlear-Implanted Children
This dissertation examines whether a cochlear implant provides congenitally deaf born children with sufficient auditory input to acquire low salient and syntactically and semantically complex functional items such as personal pronouns compared to their hearing peers.
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Past Events
The Risk and Regulation Lab from organises events and workshops in Leiden and The Hague. On this page you can read reports of the events that already took place.
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Waves and Patterns in Discrete Media: Bridging the Gaps
What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body
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Quantitative Systems Pharmacology
This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).
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The influence of music training in speech processing
In this project, we plan to combine two strands of research in speech processing: (a) the impact of prosody on speech processing and (b) the impact of musical training on speech processing. In our project we will test 8 year-old children with different degrees of musical training: (a) primary school…
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Influence of dissociation on the neural correlates of Emotional Working Memory in Borderline Personality Disorder
How do dissociative states affect the ability to suppress emotional distraction (in the context of a working memory task) in patients with Borderline Personality Disorder?
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Navigating the World of Emotions
Social Information Processing in Children with and without Hearing Loss