Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

The impact of war extends beyond destroyed buildings and torn families. In bilingual Ukraine, the ongoing war with Russia is a major driver for increasingly discarding the Russian language. What does this mean for the position of Russian in Ukraine?

Research conducted at Leiden has established that guts-on-chips respond in the same way to aspirin as real human organs do. This is a sign that these model organs are good predictors of the effect of medical drugs on the human body. Publication in Nature Communications on 15 August.

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

On Wednesday 9 March, a Faculty meeting about the war in Ukraine was held for staff and students in the Lorentz Lecture Hall. By the time the meeting started at 17.00 hrs, the 220 available seats in the lecture hall had been filled mainly by large numbers of students.

From studying molecules in the blood of corona patients to developing a new concept for vaccines. The Leiden Academic Centre for Drug Research (LACDR) has transformed many ongoing projects into Covid research projects. Hubertus Irth, scientific director of LACDR, talks about the role of his institute…

As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.

In health care, artificial intelligence is quite normal: it is used, for example, as an aid in making diagnoses. However, artificial intelligence is not yet used as much in drug development. A new prestigious partnership is therefore going to investigate how artificial intelligence can contribute to…

Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization correlate with proliferative capacity and invasiveness of cancer cells. These changes expectedly lead to altered…

On Friday, November 17, 2017, Assistant Professor Jens Iverson provided the Keynote for the annual symposium by the Minnesota Journal of International Law: Jus Post Bellum: Justice After the War.

Nerve pain is one of the most common side effects of chemotherapy. It is therefore one of the biggest reasons for cancer patients to stop treatment early. Darcy Reynolds worked on new drug candidates against this pain during her bachelor's thesis. She developed a new series of molecules that increase…

Adopting a largely chronological approach, Gerrits links the historiography of post-war Europe and the major theoretical approaches to nationalism with analysis of key historical developments and events.

Professor Ian Lilley, the Faculty of Archaeology’s Willem Willems Chair in Archaeological Heritage, was invited by Her Excellency Mrs. Marion Derckx, Ambassador of the Kingdom of the Netherlands in Australia, to present the 2022 commemoration speech for Netherlands Memorial Day on May 4th at the Netherlands-Australia…

In an essay published in three prominent European newspapers, Professor Luuk van Middelaar takes a close look at Europe’s role in the Russian invasion of Ukraine. ‘Europe shows plenty of political energy, but what is still lacking is strategic cool-headedness, in facing a nuclear power.’

Tensions ran high last week after China published a list on Wednesday of $50 billion in American products that would be hit by tariffs; a direct response to the United States' decision to implement $50 billion of tariffs on Chinese products. Could this be the start of a new trade war? And if so, what…

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Chemist Tobias Bauer discovered ways to improve drugs by encapsulating them. Packages with iron nanoparticles, for example, can stimulate immune cells. Bauer will receive his PhD on 9 June.

According to Russian propaganda Ukrainians are Nazis and people from the West are Satanists. Egbert Fortuin thinks we should take this propaganda seriously.

International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.

Endocannabinoids - the body's own marijuana - are promising departure points for drug research. Professor of Molecular Physiology Mario van der Stelt examines whether inhibiting their production can be a way to fight inflammatory brain disease and to combat obesity. Inaugural lecture 19 October.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

When Russia invaded Ukraine at the end of February, normal life there came to a halt. To ensure that affected students and researchers can continue their studies and work, professor Ellen Rutten (UvA) and assistant professor Dorine Schellens (Leiden) set up an international mentor network.

Starting January 18, the online exhibition Images of the Indonesian War of Independence, 1945-1949 can be viewed via the UBL website. The exhibition is the result of a collaboration between the Royal Netherlands Institute of Southeast Asian and Caribbean Studies (KITLV) and Leiden University Libraries…

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Promotor: M. Ubbink, Co-promotor: G. Siegal

Claire Vergerio, political scientist at Leiden University, has been awarded a VENI grant by Dutch research organisation NWO. This will allow her to conduct an in-depth analysis of the legal rights and duties of non-state actors involved in warfare. The aim is to tackle some persistent blindspots in…

Conference

Stories of resistance in the Second World War are widely covered in Dutch historiography: Hannie Schaft, Erik Hazelhoff Roelfzema, and Professor Cleveringa are some of the best known. But these accounts largely focus on the Dutch domestic perspective. On the other side of the world, a complex colonial…

Can drug screening for tuberculosis treatment be made more efficient?

The war in Ukraine has lasted almost two weeks now. What does Putin expect to achieve with his invasion and how big is the chance that the West will get involved? We phoned André Gerrits, professor and expert on Russia.

Simon Willmetts provides evidence for systematic policy of direct collussion between the TIme Inc. media empire and U.S. Central Intelligence Agency.

On 27 september historian Adam Zamoyski held a captivating lecture on his new book Napoleon: the Man behind the Myth. During this lecture, which was an initiative by Polen in Beeld and the Central and Eastern European Studies Center, Zamoyski answered the question: ‘what were the Napoleonic Wars really…

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

PhD candidate Mengxu Zhang (Division of Systems Pharmacology and Pharmacy) published a comprehensive and important review on “The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure” in Drug Metabolism Reviews.

Paul Christiaan Flu, originally from Surinam, was a brilliant tropical doctor, who in 1938 rose to the position of Rector Magnificus of Leiden University. The war years brought his lightning career to an abrupt end: his son was murdered and he himself was imprisoned in a concentration camp. A sad family…

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Promotor: B. van de Water

Promotores: A.P. IJzerman, H.W.T. van Vlijmen