This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

On Tuesday 30 April 2024 Jonny Russell successfully defended a doctoral thesis and graduated.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

PhD defence

We invite proposals for special sessions on interdisciplinary, under-studied, and emerging topics (deadline passed).

PhD defence

Adults who were abused or mistreated as a child and consequently suffer from post-traumatic stress disorder (PTSD) can benefit greatly from cognitive behavioural therapy. This is the conclusion of a study of 149 patients. Researcher and PhD candidate Chris Hoeboer is hopeful about the results and the…

PhD defence

Can we improve the treatment of post-traumatic stress disorder (PTSD)? Our young and promising psychologist Rianne de Kleine receives a Veni grant to carry out her research on the treatment of post-traumatic stress.

Four years of protracted negotiations and bitter warfare passed between the declaration of Indonesian independence on 17 August, 1945, and the official transfer of sovereignty on 27 December, 1949.

Food relations (through production, distribution, circulation, exchange and waste) represent the embodiment of our relation to the environment.

Members of our research team give different types of presentations and lectures.

The WIIS-NL blog provides articles on gendered international security issues taking a multi-disciplinary approach which includes but is not limited to WIIS focus areas. This blog aims to reach a broad audience of academics, practitioners, students, and interested members of the general public.

The mission of Thamyris/Intersecting is to rigorously bring into encounter the crucial insights of black and ethnic studies, gender studies, and queer studies, and facilitate dialogue and confrontations between them.

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The 9th Network Europe Conference in Edinburgh was held at June 2017 in Edinburgh and organized by the Europa Institut Zurich. The contributions of the conference are now published.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

Nietzsche's famous notion 'amor fati' is often associated with the Stoic maxim to 'live in accordance with nature'; we have to fully accept our fates in order to attain happiness. But is happiness really what Nietzsche's 'amor fati' is about? And how to account for all the fiercely critical remarks…

‘Visibility and secrecy are both valuable tactics and should not be antagonized in LGBT movements, ’ says Jingshu Zhu. Zhu defended her dissertation on Wednesday 21 February.

Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.

Is blended care a feasible and effective treatment method for social anxiety in adolescence?

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.

A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

Do you often find yourself exhausted in the lecture hall or at your workplace? Not great for your mental well-being, as Laura Pape knows. She is investigating how an online self-help program can assist in addressing sleep issues and preventing mental health problems. Join her on this elevator pitch…

PhD defence

This project focuses on a striking parallelism between two macro-groups of languages: southern Italian dialects and the so-called split-ergative languages, like Basque, Georgian, Dyirbal, Hindi/Urdu.

The Common Market Law Review welcomes contributions from any country. Articles will be subjected to a review procedure by the Editorial Board.

Graduates of the interdisciplinary Science for Sustainable Societies programme are attractive candidates for a broad range of employers in a field that is growing, and necessary in order to transition to a more sustainable and adaptive society.

A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers. However, there are far more graduates than vacancies, especially in mental health care, and competition is therefore fierc…

A recent publication by Biopharmaceutics PhD-candidate Eva Kritikou has been accepted by the renowned scientific journal Scientific Reports.

Retrospection over the last 40 years the most important changes in care and research, where transparency accountability and guidelines became leading. On Huntington’s disease and cerebrovascular disorders the most important changes are illustrated.

A Spanish translation of Herman Paul’s 'Key Issues in Historical Theory' has appeared under the title 'La llamada del pasado: claves de la teoría de la historia'.

We invite proposals for workshops and tutorials, to be held in Leiden on 01 July 2024 (deadline passed).

Every year the Leiden Univeristy faculty of Humanitites organizes a linguistic summer school. This year Dr. Alessia Prioletta (Paris) will be teaching a class titled 'Non-Sabaic Ancient South Arabian languages'. The Summer school will be held from July 11 to July 22 at the faculty of Humanities of Leiden…

Perec’s Lieux project consists of texts describing the author's places of memory, photographs, personal documents and ephemera collected in the street.