1,138 search results for “since molecular” in the Public website
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François Mesnard
PhD at Université de Picardie Jules Verne, Amiens - France
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Resolving rapid radiations
What are the phylogenetic relationships among the members of speciation bursts?
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Unravelling molecular mechanisms in transcription-coupled nucleotide excision repair
PhD defence
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LED3 Lecture: Tailor-made Biomolecules by Molecular Evolution
Lecture
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Contextual glucocorticoid signaling in-vivo: A molecular perspective
PhD defence
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Characterization of DNA-replication proteins and their molecular mechanisms
PhD defence
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Studies on molecular basics of metabolic syndrome in zebrafish
PhD defence
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Nucleotide excision repair: from molecular mechanisms to patiënt phenotypes
PhD defence
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Probing Molecular Layers with Low-Energy Electrons
PhD defence
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Updates in Molecular Diagnosis and Targeted Treatment of Thyroid Neoplasia
PhD defence
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‘Visual art has been a form of communication since its inception’
Visual art played an important role in the development of cooperative human behaviour. This is the finding of Larissa Mendoza Straffon, a PhD candidate in archaeology, whose dissertation explores the biological and psychological foundations of visual art.
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‘Since coming to Leiden, I’ve never worried that something might be too difficult to do’
The Italian physicist Andrea Morello is one of the pioneers of the quantum revolution. He is currently doing research at the University of New South Wales in Sydney, but cherishes his time as a PhD candidate in Leiden.
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report: inadequate protection from violence for children in youth care since 1945
A significant percentage of children who have spent a period in youth care institutions or foster homes since 1945 received inadequate protection from physical, psychological and sexual violence. Interventions by supervisory authorities in cases involving violence were inadequate.
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Colloidal LEGO with peptides
Kros
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Fundamental Research in Energy & Sustainability
Twenty years from now, the world population is estimated to be around 9 billion people (now 8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this population will result in an enormous increase in the demand for food, consumables, water…
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Fundamental Research in Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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NL-BioImaging AM
NL-BioImaging AM is a distributed research infrastructure aimed at promoting progress in the most cutting edge microscopy technologies and providing open access to these technologies to a broad community of academic and industrial users. All Netherlands bio(medical) microscopy centers participate.
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Research
Research at the SBC group is comprised of the following research themes:
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Joachim Kopka
PhD at the Max Planck Institute of Molecular Plant Physiology, Golm – Germany
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Biology (MSc)
The master’s programme Biology at Leiden University offers seven specialisations ranging from Cell Biology to Molecular Genetics. The programme prepares you for a career in research within or outside academia.
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Science
The Faculty of Science
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Participants
The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).
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e-infrastructure for metabolomics
an integrated, secure, permanent, on-demand service-driven, privacy-compliant and sustainable e-infrastructure for the processing, analysis and information-mining of the massive amount of medical molecular phenotyping and genotyping data that will be generated by metabolomics applications now entering…
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Staff members
These are the staff members of the Leiden - Latin America and the Caribbean Centre
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Morphogenesis and protein production in Aspergillus niger
Promotor: Prof.dr. C.A.M.J.J. van den Hondel, Dr. ir. V. Meyer, Co-promotor: Dr. A.F.J. Ram
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Imaging
The imaging group focuses on bio-imaging, image analysis and visualization.
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Evolution & Biodiversity in Microbial Sciences
Microbial Sciences' contribution to the Evolution & Biodiversity research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.
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mRNA and drug delivery with lipid-based nanoparticles
This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.
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Training and courses
There are several training oportunities within the cell observatory
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The archaellum: a rotating type IV pilus
Now online in Molecular Microbiology our studies on the motility of Sulfolobus acidocaldarius and its unique swimming organelle, the archaellum.
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Cancer Pathogenesis and Therapy
Cancer represents a formidable current and future global health challenge. The LUMC medical research profile Cancer Pathogenesis and Therapy charges this challenge by developing and implementing innovative patient-tailored, multimodal diagnostic methods and treatment modalities.
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The Role of Target Binding Kinetics in Drug Discovery
Source: ChemMedChem (2015)
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Collaborative and effective drug development
There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…
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Life Science & Technology (MSc)
Increased molecular knowledge of the mechanisms of processes in the cell can lead to better medicines or new methods for combating diseases. Our MSc students in Life Science and Technology (LST) specifically learn to understand the molecular and structural chemical and biological aspects of disease-related…
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Project TARGET: Fatal firearm violence down by 50% since the ‘90s of the previous century
Project TARGET is a research project aimed at the relation between the illegal arms trade and firearm violence. In a study conducted in seven countries, the researchers took a look at the differences and similarities. Katharina Krüsselmann and Marieke Liem took a closer look at the situation in the…
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Modeling energy conversion dynamics at interfaces
Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…
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Redox catalysis for a sustainable energy infrastructure
The main research theme in the group of Dennis Hetterscheid is to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. Reduction of protons generates hydrogen that can be used as a chemical fuel. Alternatively to gaseous hydrogen, the reduction…
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Admission requirements
The maximum number of students that can be enrolled in the first year of the programme of the master Biomedical Sciences at LUMC is 100.
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Indigoid chromophores - a platform for light responsive nanosystems and molecular machines
Lecture
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Sharp rise in purchasing power since 1977, inequality stable in recent years
In the period 1977–2020, the purchasing power of the Dutch population increased by 58 percent. The sharpest rise occurred from 1999–2009 (22 percent). This is the outcome of research conducted by Leiden University and Statistics Netherlands (CBS).
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Reactivity on interstellar ice analogues
The
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Sodium ion binding pocket mutations and adenosine A2A receptor function
Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)
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Catalysis and Surface Chemistry
In the Catalysis and Surface Chemistry group, we investigate how catalysis works on the molecular level. The group is divided in six subgroups, focusing on different aspects of heterogeneous catalysis, homogeneous catalysis and electrocatalysis.
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?