In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…

The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…

Selected publications of the Cardiovascular and Metabolic Therapeutics group.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

Over the past century, the world population has grown exponentially, as has our need for energy and raw materials. If we wish to continue to live prosperously in the future, we have to radically restructure our economy and consumption. Scientific research shows us how to do this.

This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

JUSTREMIT is an ERC-funded project that brings together political theory, ethnography, and security studies in an interdisciplinary study of remittances and global justice.

In an (Dutch) interview with the regional Leiden newspaper “Leidsch Dagblad”, Ruben Huele and Ester van der Voet talk about the recently started project PUMA (Prospecting the Urban Mines of Amsterdam).

An interdisciplinary team of Leiden researchers has discovered that wasting syndrome, a severe byproduct of tuberculosis, is the same for all humans and animals studied. The discovery offers new opportunities to investigate the still insufficiently understood condition. The scientists also developed…

In the Phenomix Medical Delta Field Lab, which was officially opened on Thursday 9 July, scientists, healthcare institutions and businesses work together to develop innovative applications in the field of metabolomics. This research field makes it possible to determine which drugs will be effective…

Sleep disorders have a significant influence on our physical and emotional health. Sleep should therefore receive more attention within lifestyle medicine, says Professor Gert Jan Lammers. He will give his inaugural lecture on Friday 20 May entitled: ‘Getting to sleep’.

The Dutch X-omics Initiative has received seventeen million euros from NWO as part of the National Roadmap for Large-Scale Infrastructure. Leiden University’s metabolomics research led by Thomas Hankemeier is one of the participators.

Environmental scientists in Leiden have found that the so-called leaf economics spectrum for plants can not only be applied to terrestrial ecosystems, such as forests and grasslands, but also to wetlands. Furthermore, they showed that wetland plants generally have a fast-return strategy, meaning they…

How is it that some covid-19 patients are affected much worse than others? Can we predict beforehand which of them will develop critical symptoms Professor Thomas Hankemeier, together with a diverse consortium of universities, academic hospitals and industrial partners, is looking for the answers to…

PhD research recently completed by pharmacologist Margreke Brill shows that morbidly obese patients should be given a different dosage of the drugs Cefazolin and Midazolam. This could also apply to other drugs such as anti-cancer drugs as well as antibiotics and Margreke Brill is advocating a change…

Anthe Janssen, a PhD student in the Molecular Physiology research group of Prof. Mario van der Stelt, has been awarded the Public's Choice Prize for Best Oral Presentation during the Young Medicinal Chemist Symposium '18 in Ljubljana, Slovenia.

For his significant original contributions in the field of carbohydrate research, chemist Jeroen Codee will be awarded the biennial Carbohydrate Research Award for Creativity in Carbohydrate Chemistry.

Annelot van Esbroeck-Weevers, PhD student at the Molecular Physiology research group at the Leiden Institute of Chemistry, headed by Dr. Mario van der Stelt, has been awarded the Best Oral Communication Prize at the 8th European Workshop on Cannabinoid Research, held from 31 August to 2 September 2017…

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

With a grant from NWO, Thomas Hankemeier will develop new methods to better understand the dynamics of the building blocks of life, such as cells, enzymes, and metabolites. He does this together with the University of Amsterdam and a number of companies.

Organ-on-chip technology is used in drug research and customized treatments for patients. Research Institutes and industry join forces within the Institute for human Organ and Disease Model Technologies (hDMT) that was officially launched on May 18. Combining facilities, people and expertise will allow…

Tuesday May 24th, the LACDR Annual Spring Symposium was held.

Mimicking photosynthesis to produce bioplastics sustainably and efficiently. Researchers from the Institute of Biology Leiden (IBL) and the Leiden Institute of Chemistry (LIC) will assess this new approach. ‘An exciting opportunity to explore a new, appealing research topic in a collaboration between…

Professors Jos Raaijmakers (NIOO) and Gilles Van Wezel (IBL) received an STW Perspectief- grant of €3 million from the Dutch Technology Foundation and several supporting companies.

As of 1 September Miranda van Eck will be the new Scientific Director of the Leiden Academic Centre for Drug Research. She succeeds Hubertus Irth, who led the institute since 2016. Van Eck has been appointed for a period of four years.

Dying from viral infection due to organ failure and blood loss: we still know little about how it can happen. Among other things, Huaqi Tang developed an organ-on-a-chip to figure it out. 'These technologies can offer unprecedented opportunities to fight the viruses that threaten our society.' Tang…

The Municipality of The Hague called on researchers to come up with a proposal for an innovative research project on problems big cities face such as energy transition. Four of the five projects that have been granted funding come from researchers from Leiden University.

The current production of a number of critical metals is insufficient for the large-scale transition to electric vehicles. This is the conclusion of a report by environmental scientist Benjamin Sprecher and organisations Copper8 and Metabolic. As a solution, they advocate more electric car-sharing,…

Destroying proteins from the Golgi apparatus of the cell in a controlled manner. That is the focus of chemist Marta Artola’s pioneering research. By developing a groundbreaking technology to target specific proteins in the Golgi, Artola aims to unlock new ways for drug development. For this ambitious…

Effectively treating a severe case of pneumonia is often challenging. Identifying the pathogen behind it can be difficult. PhD candidate Ilona den Hartog tried something new: ‘We searched for answers in substances our own body produces.’ PhD defence on 17 September.

The Environmental Sciences Research Prize 2012 has been awarded to CML researcher David Font Vivanco by the Environmental Scientists Association of Catalonia.

There seem to be genes that influence how our brains develop over time. A large international consortium has discovered this with an extensive study. The results of the study were recently published in Nature Neuroscience.

In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…

Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…

Researchers led by Professor of Chemistry Marcellus Ubbink have recently published a study in Proceedings of the National Academy of Sciences (PNAS) about the dynamics of an important redox enzyme. This work was accomplished thanks to an NWO VICI subsidy granted to Professor Ubbink.

Researchers from Leiden University will develop a new approach to study the biomarkers of Alzeimer’s disease. This approach focusses on the molecular messengers of the cells. The project, led by Thomas Hankemeier and coordinated by Yuliya Shakalisava (Leiden Academic Centre for Drug Research, LACDR),…

For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…

The Dutch Research Council (NWO) has awarded 400.000 euros in funding to Lotte van Dillen, associate professor at the unit of Social, Economic and Organizational Psychology. With this grant, Lotte van Dillen will investigate how daily distractions influence our dietary consumption habits and glucose…

A full overview of BPOC/SSNMR PhD theses.

An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

The Faculties of Leiden University have developed several themes for research cooperation between Leiden University and its Indonesian partners.

The representation of women in science is improving, also at the Faculty of Science. On 8 March – International Women's Day – we highlight the work of female scientists from our faculty.

Leiden professor of Cellular Immunology of Parasitic Infections Maria Yazdanbakhsh receives the prestigious NWO Spinoza Prize this year. This, in many ways, border-crossing scientist contributes with her research to more effective vaccines against parasitic infections and better medication for inflammatory…

During Seeing Stars Leiden all the lights around Leiden Observatory will be switched off for an hour. The more lights that go out, the more stars we’ll be able to see. For the LUMC, this is the perfect moment to think about our biological clock, the topic researchers from the BioClock consortium are…

European dependence on Russian gas, earthquake damage in Groningen and the changing climate: the call for an energy transition is getting louder. This transition will be accompanied by an increasing demand for 'new' raw materials. The Geo-Resources for the Future minor looks at exactly that developm…