357 search results for “metabolism” in the Public website
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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JUSTREMIT
JUSTREMIT is an ERC-funded project that brings together political theory, ethnography, and security studies in an interdisciplinary study of remittances and global justice.
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PhD: Targeting electron transport chain in Listeria monocytogenes for novel antibiotic development
Science, Leiden Institute of Chemistry (LIC)
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The city as a mine has the future
In an (Dutch) interview with the regional Leiden newspaper “Leidsch Dagblad”, Ruben Huele and Ester van der Voet talk about the recently started project PUMA (Prospecting the Urban Mines of Amsterdam).
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Scientists find strong evidence that wasting syndrome is the same for all organisms
An interdisciplinary team of Leiden researchers has discovered that wasting syndrome, a severe byproduct of tuberculosis, is the same for all humans and animals studied. The discovery offers new opportunities to investigate the still insufficiently understood condition. The scientists also developed…
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Phenomix Field Lab offers promising healthcare solutions
In the Phenomix Medical Delta Field Lab, which was officially opened on Thursday 9 July, scientists, healthcare institutions and businesses work together to develop innovative applications in the field of metabolomics. This research field makes it possible to determine which drugs will be effective…
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‘Sleep should play a greater role in lifestyle research’
Sleep disorders have a significant influence on our physical and emotional health. Sleep should therefore receive more attention within lifestyle medicine, says Professor Gert Jan Lammers. He will give his inaugural lecture on Friday 20 May entitled: ‘Getting to sleep’.
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Seventeen million for Dutch X-omics Initiative
The Dutch X-omics Initiative has received seventeen million euros from NWO as part of the National Roadmap for Large-Scale Infrastructure. Leiden University’s metabolomics research led by Thomas Hankemeier is one of the participators.
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Why plants in wetlands are highly productive
Environmental scientists in Leiden have found that the so-called leaf economics spectrum for plants can not only be applied to terrestrial ecosystems, such as forests and grasslands, but also to wetlands. Furthermore, they showed that wetland plants generally have a fast-return strategy, meaning they…
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Predicting and preventing Covid-19: 1 million euros for corona research
How is it that some covid-19 patients are affected much worse than others? Can we predict beforehand which of them will develop critical symptoms Professor Thomas Hankemeier, together with a diverse consortium of universities, academic hospitals and industrial partners, is looking for the answers to…
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Different medication dosage for morbidly obese patients
PhD research recently completed by pharmacologist Margreke Brill shows that morbidly obese patients should be given a different dosage of the drugs Cefazolin and Midazolam. This could also apply to other drugs such as anti-cancer drugs as well as antibiotics and Margreke Brill is advocating a change…
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Anthe Janssen wins the YMCS Public's Choice Prize
Anthe Janssen, a PhD student in the Molecular Physiology research group of Prof. Mario van der Stelt, has been awarded the Public's Choice Prize for Best Oral Presentation during the Young Medicinal Chemist Symposium '18 in Ljubljana, Slovenia.
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Jeroen Codee wins the Carbohydrate Research Award 2017
For his significant original contributions in the field of carbohydrate research, chemist Jeroen Codee will be awarded the biennial Carbohydrate Research Award for Creativity in Carbohydrate Chemistry.
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Annelot van Esbroeck wins Best Oral Communication Prize
Annelot van Esbroeck-Weevers, PhD student at the Molecular Physiology research group at the Leiden Institute of Chemistry, headed by Dr. Mario van der Stelt, has been awarded the Best Oral Communication Prize at the 8th European Workshop on Cannabinoid Research, held from 31 August to 2 September 2017…
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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Understanding the building blocks of life better
With a grant from NWO, Thomas Hankemeier will develop new methods to better understand the dynamics of the building blocks of life, such as cells, enzymes, and metabolites. He does this together with the University of Amsterdam and a number of companies.
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The Netherlands becomes global player organ-on-chip technology
Organ-on-chip technology is used in drug research and customized treatments for patients. Research Institutes and industry join forces within the Institute for human Organ and Disease Model Technologies (hDMT) that was officially launched on May 18. Combining facilities, people and expertise will allow…
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Looking back at the LACDR Spring Symposium 2016
Tuesday May 24th, the LACDR Annual Spring Symposium was held.
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Can we make bioplastics with artificial photosynthesis?
Mimicking photosynthesis to produce bioplastics sustainably and efficiently. Researchers from the Institute of Biology Leiden (IBL) and the Leiden Institute of Chemistry (LIC) will assess this new approach. ‘An exciting opportunity to explore a new, appealing research topic in a collaboration between…
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New STW-grant to redirect the plant micro biome: “Back to the Roots”
Professors Jos Raaijmakers (NIOO) and Gilles Van Wezel (IBL) received an STW Perspectief- grant of €3 million from the Dutch Technology Foundation and several supporting companies.
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Miranda van Eck new Scientific Director of the LACDR institute
As of 1 September Miranda van Eck will be the new Scientific Director of the Leiden Academic Centre for Drug Research. She succeeds Hubertus Irth, who led the institute since 2016. Van Eck has been appointed for a period of four years.
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Organ failure caused by viruses, how does it work? Now there are methods to find out
Dying from viral infection due to organ failure and blood loss: we still know little about how it can happen. Among other things, Huaqi Tang developed an organ-on-a-chip to figure it out. 'These technologies can offer unprecedented opportunities to fight the viruses that threaten our society.' Tang…
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Innovative knowledge projects start in The Hague
The Municipality of The Hague called on researchers to come up with a proposal for an innovative research project on problems big cities face such as energy transition. Four of the five projects that have been granted funding come from researchers from Leiden University.
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Transition to electric vehicles puts heavy pressure on production of critical metals
The current production of a number of critical metals is insufficient for the large-scale transition to electric vehicles. This is the conclusion of a report by environmental scientist Benjamin Sprecher and organisations Copper8 and Metabolic. As a solution, they advocate more electric car-sharing,…
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Environmental Sciences Research Prize awarded to David Font Vivanco
The Environmental Sciences Research Prize 2012 has been awarded to CML researcher David Font Vivanco by the Environmental Scientists Association of Catalonia.
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Major international study links genes to brain structural changes over time
There seem to be genes that influence how our brains develop over time. A large international consortium has discovered this with an extensive study. The results of the study were recently published in Nature Neuroscience.
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Leiden: The scene of the Zebrafish Disease Models conference 2018
In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…
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New substances inhibit inflammation in the brain
Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…
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Research shows protein movement is important
Researchers led by Professor of Chemistry Marcellus Ubbink have recently published a study in Proceedings of the National Academy of Sciences (PNAS) about the dynamics of an important redox enzyme. This work was accomplished thanks to an NWO VICI subsidy granted to Professor Ubbink.
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NWO Open Competition funding for research into distracted consumption
The Dutch Research Council (NWO) has awarded 400.000 euros in funding to Lotte van Dillen, associate professor at the unit of Social, Economic and Organizational Psychology. With this grant, Lotte van Dillen will investigate how daily distractions influence our dietary consumption habits and glucose…
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New project funded to study Alzheimer's disease
Researchers from Leiden University will develop a new approach to study the biomarkers of Alzeimer’s disease. This approach focusses on the molecular messengers of the cells. The project, led by Thomas Hankemeier and coordinated by Yuliya Shakalisava (Leiden Academic Centre for Drug Research, LACDR),…
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Novel detection method for iron in Alzheimer’s brain
For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…
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PhD Theses
A full overview of BPOC/SSNMR PhD theses.
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Awards and Grants 2018
An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.
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Activity-based protein profiling for drug discovery
Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…
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Research
The Faculties of Leiden University have developed several themes for research cooperation between Leiden University and its Indonesian partners.
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Female talent in the spotlight
The representation of women in science is improving, also at the Faculty of Science. On 8 March – International Women's Day – we highlight the work of female scientists from our faculty.
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LUMC professor Maria Yazdanbakhsh receives Spinoza Prize
Leiden professor of Cellular Immunology of Parasitic Infections Maria Yazdanbakhsh receives the prestigious NWO Spinoza Prize this year. This, in many ways, border-crossing scientist contributes with her research to more effective vaccines against parasitic infections and better medication for inflammatory…
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How do we maintain a healthy biological clock?
During Seeing Stars Leiden all the lights around Leiden Observatory will be switched off for an hour. The more lights that go out, the more stars we’ll be able to see. For the LUMC, this is the perfect moment to think about our biological clock, the topic researchers from the BioClock consortium are…
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LDE minor focuses on resources needed for energy transition
European dependence on Russian gas, earthquake damage in Groningen and the changing climate: the call for an energy transition is getting louder. This transition will be accompanied by an increasing demand for 'new' raw materials. The Geo-Resources for the Future minor looks at exactly that developm…
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€8.5m for research into healthy ageing and vitality
A large multidisciplinary team of experts on ageing has secured over €8.5m for a major study of which factors and solutions promote healthy ageing and increase vitality. The LUMC and the Leiden Academic Centre for Drug Research (LACDR) are two of the centres involved in this national research projec…
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Stans Prize for Kevin Groen
The ‘Stans Prize 2015' (for the best thesis, report or article produced by a CML student) has been awarded to Kevin Groen. Other CML prizes were awarded to Laura Bertola, Patrik Henriksson and Rene Kleijn.
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Marc Baggelaar graduates cum laude on body’s own marijuana
PhD candidate Marc Baggelaar of the Leiden Institute of Chemistry (LIC) graduated cum laude on Thursday 6 April. His thesis on the endocannabinoid system in the brain is very comprehensive and of high quality, according to the jury. ‘A very talented young scientist, that definitely belongs to the top…
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Miranda van Eck inaugural lecture: detergent tablets for clean, fat-free blood vessels
In her inaugural lecture on 11 September, Miranda van Eck, Professor of Cardiovascular and Metabolic Therapeutics, addressed her research related to developing medications to keep our blood vessels clean.
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300 million euros for new international stem cell consortium
The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…
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Interview with PhD student: Doris van Bergeijk
Leiden University is partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH interviewed Doris van Bergeijk: PhD student of the project…
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New measuring method facilitates drug research
Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.
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Three VICI grants for Leiden researchers
Three Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Scientific Research (NWO). They each receive 1.5 million Euro to develop their own research project in the coming 5 years.
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Towards a liveable future
Humans have influenced nature since as early as the Ice Age, and over the past century man’s impact has become even greater with our many new technologies and a growing world population. Leiden researchers study this impact and how we can keep it within reasonable limits so that nature can be preserved.…
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Hard chews: why mastication played a crucial role in evolution
We do it every day but barely give it a thought: chewing our food. But the ‘simple’ process of masticating food may have played a crucial role in the evolution of our jaws, facial muscles and teeth.