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This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Promotor: Prof.dr. E.J.J. Groenen

Recent publications

PhD defence

Lecture, Lecture part of a series

On 1 August, Lars Jeuken started work as Professor of Biophysical Chemistry at the Leiden Institute of Chemistry (LIC). His research is at the intersection of biology and chemistry, but also involves physics and nanotechnology. Jeuken: ‘By linking nanoparticles to proteins and bacteria, we want to convert…

PhD defence

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

Engineered nanomaterials (ENMs) are widely used, and nanotechnological innovations grow with rapid pace. Studies on nanotoxicology have demonstrated that chemical toxicology as well as particle toxicology should be accounted for in predicting the safety of ENMs.

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…

Lecture, NGL lecture

On this page, you will find the recordings of the online This Week's Discoveries from May 12, 2020, as well as a list of speakers since October 2015.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

The Basics and Applications to Plant Sciences will be held physical. See below for more information.

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

SEAtrans: an interdisciplinary research project that aims at studying the dynamics and processes of transitions in society-nature interactions in Southeast Asian societies.

The programme of the 3rd International Workshop on Klinefelter Syndrome, Trisomy X, and XYY. International Workshop theme: 'A life-course perspective'

Mimicking photosynthesis to produce bioplastics sustainably and efficiently. Researchers from the Institute of Biology Leiden (IBL) and the Leiden Institute of Chemistry (LIC) will assess this new approach. ‘An exciting opportunity to explore a new, appealing research topic in a collaboration between…

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

A scenario building web-tool and knowledge package to enable multi-level decision making for the transition to the Circular Economy

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

Key publications of the Analytical BioSciences and Metabolomics group

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea