3,571 search results for “medical drug violence” in the Public website
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How Leiden's drug pioneers have switched to Covid research
From studying molecules in the blood of corona patients to developing a new concept for vaccines. The Leiden Academic Centre for Drug Research (LACDR) has transformed many ongoing projects into Covid research projects. Hubertus Irth, scientific director of LACDR, talks about the role of his institute…
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Medical Delta professor Marcel Reinders: ‘You need collaboration to make a real impact’
Prof. Marcel Reinders is a data science specialist at Delft University of technology. Using smart algorithms, he searches for links in complex data. For example, he studies patterns in DNA that lead to aberrant cell behaviour. This knowledge will help detect serious diseases such as Alzheimer's and…
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Combatting violence against children: what are the lessons learnt?
In the context of the 2021 Day of General Discussion of the UN Committee on Rights of the Child, this time dedicated to alternative care, Defence for Children in collaboration with Leiden University has contributed with a paper on the 2019 Dutch Inquiry Committee on Historical Child Abuse in Alternative…
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Orange the World: Visible and invisible violence against women
On 25 November, the global 16-day campaign 'Orange the World' against violence against women and girls started. Leiden University will also be paying attention to this campaign. On Friday 9 December, Renate van der Zee and Marieke Liem will give a lecture at the Campus The Hague (Spanish Steps, Wijnhaven)…
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Proving discriminatory violence at the European Court of Human Rights
On Tuesday 23 May 2017, Jasmina Mackic will defend her doctoral thesis ‘Proving discriminatory violence at the European Court of Human Rights’. The defence will start at 15.00 hrs, at the Academy Building of Leiden University, Rapenburg 73. The supervisor of the research is Vice Dean and Professor of…
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Seven new Medical Delta professors
Medical Delta has appointed seven professors who will bridge the medical worlds of Leiden, Delft and Rotterdam.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Debate: ‘A Crisis on the Rise? The Impact of Violence and Impunity on Mexican Society’
Mexico is currently facing an unprecedented social and political crisis, with expanding criminal and political violence, rampant impunity and crumbling political institutions. Next to the daily report of anonymous victims of violence, last summer in Central Mexico at least 15 citizens were executed…
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Academy Building ‘oranged’ to stop violence against women
Eliminate violence against women. That is the message of the Orange the World campaign. Leiden University is joining in this year, hence the ‘oranged’ Academy Building and Oude UB.
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FvD politican Gideon van Meijeren in court for inciting violence
The Netherlands Public Prosecution Service has demanded that Gideon van Meijeren, Dutch Member of Parliament in the Forum for Democracy (FvD) party, be handed 200 hours of community service for inciting violence. Marloes van Noorloos, Associate Professor of Criminal Law, discusses when a comment turns…
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Leiden University signs Amnesty manifesto against sexual violence
Leiden University signed the Amnesty International ‘Let’s talk about YES’ manifesto on 10 March, confirming the university’s commitment to preventing sexual violence. Steps will also be taken to make sure that everyone within the university feels responsible for a culture in which sex is based on equality…
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From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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From scientific idea to promising new drug
Many pharmaceutical companies no longer have their own lab and are working more closely with universities and start-ups of scientists. Professor of Science-Based Business Simcha Jong is researching how scientific ideas result in new drugs, including at the Leiden Bio Science Park (LBSP).
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market needs: new course for master’s students focuses on quality in drug development
Immediately connect with the needs of industry with your master’s degree. The new course Practical Aspects of Quality Management in Pharma and Biotech provides just that. The LACDR and LUMC set up the course together with the Biotech Training Facility, located at the Leiden Bio Science Park. The first…
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Leiden based research confirms systematic and excessive violence in Indonesia
New research has confirmed that the Dutch military used systematic, extreme violence against Indonesians. In his book Soldaat in Indonesië (Soldier in Indonesia), to be released at the end of October, historian Gert Oostindie draws the same conclusions using different sources. He presents new findings…
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NMR Facility
Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…
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ZonMw grant for research on domestic violence family treatment
Although domestic violence often affects multiple family members, parents and children are usually treated separately for their traumatic experiences. In collaboration with women's shelter Rosa Manus, forensic partner the Waag, the municipality of Leiden and their colleagues from LUBEC (Leiden University…
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Career Foreign Fighters: Expertise Transmission Across Insurgencies
Jeanine de Roy van Zuijdewijn, Chelsea Daymon and David Malet, wrote RESOLVE Network Research Report that examines career foreign fighters who have traversed from one insurgency to another.
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Drone imagery in Islamic State propaganda: flying like a state
This article provides a comprehensive analysis of the Islamic State's use of images taken by drones, drawing on a dataset of ISIS propaganda images from October 2016 to December 2018.
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Parameter optimization toward optimal microneedle-based dermal vaccination
Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.
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Kearifan Kesehatan Lokal: indigenous medical knowledge and practice for integrated nursing of the elderly with cardiovascular disease in Sumedang
The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.
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LUMC involved in development of novel drugs to treat and prevent SARS-CoV-2 and other coronaviruses
The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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Alumnus Robert Ietswaart: ‘Machine learning is revolutionising drug discovery’
Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…
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Laura Heitman
Science
l.h.heitman@lacdr.leidenuniv.nl | +31 71 527 4558
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Phenoconversion
Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…
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Juan Masullo Jimenez
Faculteit der Sociale Wetenschappen
j.masullo@fsw.leidenuniv.nl | +31 70 800 3879
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De Witte et al publish in Nature Drug Discovery Reviews
Nature Reviews Drug Discovery volume 18, pages 82–84 (2019). The implications of target saturation for the use of drug–target residence time Wilbert de Witte, Meindert Danhof, Piet van der Graaf, and Elizabeth de Lange
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Professor Mariëlle Bruning elected Member of the Expert Group Violence Against Children of the Council of Europe (2018-2019)
Mariëlle Bruning, Professor of Child Law, is elected Member of the Expert Group on Responses to violence against children (CAHENF-VAC), which is established to assist the Ad hoc Committee for the Rights of the Child (CAHENF) of the Council of Europe.
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Leiden University Libraries acquires remarkable medical manuscripts
Leiden University Libraries (UBL) has been able to acquire four remarkable medical manuscripts partly thanks to support from the Friends of Leiden University Libraries, the Pieter van Foreest Stichting and the Van de Sande Fonds. All four are largely written in Dutch and can be dated between 1595 and…
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The chemistry behind cancer drugs: searching for fewer side effects
PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…
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Drug discovery 3.0: more effective and humane
Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.
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INSIGHT: focus on the way in which firearms are related to firearms violence
The European Commission awarded the project proposal INSIGHT, a follow-up project on illegal firearms trafficking and gun violence from Professor Social Resilience and Security Marieke Liem and PhD-researcher Katharina Krüsselmann of the Institute of Security and Global Affairs (ISGA).
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Impurities in sugar excipients could cause drugs to fail
Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.
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Ariane Briegel appointed as Medical Delta professor
Yesterday, eight professors were simultaneously inaugurated as ‘Medical Delta professor’, at Leiden University, LUMC, TU Delft, Erasmus University and Erasmus MC. Ariane Briegel, researcher of the Institute of Biology Leiden of Leiden University, also received the double appointment.
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Sensing drug responses of single cells using optical tweezers
Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.
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Dental remains shed light on drug use in 19th century Dutch village
Archaeologist Bjørn Peare Barthold suspected farmers in a doctorless 19th century Dutch village may have been self-medicating to manage pain and disease. By examining the skeletons' dental calculus this hypothesis could be tested. Science Magazine interviewed him about this new technique.
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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A dilemma: When and how to use the concept of “culture” in medical anthropological practice?
When and how to use the concept of “culture” . To medical anthropologists this is a core question, but also a challenging one.
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Brains react differently to ADHD medication than expected
A tried and tested medication for treating ADHD works differently than expected in the brains of healthy individuals during rest: rather than stimulating brain activity, it suppresses it.
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New project uses artificial intelligence in drug development
In health care, artificial intelligence is quite normal: it is used, for example, as an aid in making diagnoses. However, artificial intelligence is not yet used as much in drug development. A new prestigious partnership is therefore going to investigate how artificial intelligence can contribute to…
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Countering nerve pain caused by chemotherapy with new drug
Nerve pain is one of the most common side effects of chemotherapy. It is therefore one of the biggest reasons for cancer patients to stop treatment early. Darcy Reynolds worked on new drug candidates against this pain during her bachelor's thesis. She developed a new series of molecules that increase…
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Monitoring Cytoskeletal Conductance Variation for Sensing Cancer Drug Resistance
Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization correlate with proliferative capacity and invasiveness of cancer cells. These changes expectedly lead to altered…
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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Arteriosclerosis and drug discovery: two young researchers win Krijn Rietveld Award for innovative research
One discovered that arteriosclerosis resembles an autoimmune disease, while the other developed a system to aid in the search for new medications. For these achievements, Marie Depuydt and Jurren de Groot were awarded the Krijn Rietveld Memorial Innovation Award on the evening of Tuesday 4 June.
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How drugs work better when encapsulated in nanoparticles
Chemist Tobias Bauer discovered ways to improve drugs by encapsulating them. Packages with iron nanoparticles, for example, can stimulate immune cells. Bauer will receive his PhD on 9 June.