Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Behavioral and neural mechanisms underlying risky decision-making in adolescents

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

As an alternative to the diving board shaped force sensor, we are now developing a magnetically levitated small superconducting particle – or ‘Lead Zeppelin'' – as our mechanical resonator. We explore routes towards detection of gravity between small objects.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

A new computer simulation shows the promising possibilities of the booming field of topology. Smartly designed mechanical structures carry sound exclusively one way and are immune to fabrication errors. Publication on 17 July in Nature Physics.

Anne Meeussen, who defended her PhD thesis on programmable materials in May 2021 earning cum laude honours, won the second Ehrenfest-Afanassjewa prize awarded by the Dutch Physics Council.

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…

An important discovery makes it possible to communicate complex information among multiple people without the message being cracked. The communication can also relate to complex information.

PhD defence

Physics and Engineering Approaches to Biomedicine and Pharmacology

PhD defence

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

On the 4th of November, Aliza successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Aliza on this achievement!

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

How can international investment law and arbitration take account of the public interest in, and more broadly, the public dimension of, the relations between foreign investors and host States ?

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

How and why latex bearing plants select specific chemical compounds for eco-chemical interactions with its biotic factors?

This research programme aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services to facilitate strategic management of natural resources. To this end, we address urgent challenges in relation to the mechanisms involved…

What is the state of access to justice in real property grievances in today’s Libya, and how should it be improved?

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Delineating psychophysiological endophenotypes of social anxiety disorder

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

-

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…