An e-coaching programme helps people with chronic kidney disease, particularly in areas that patients themselves want to work on. ‘A healthy lifestyle is important for patients with kidney disease: it can slow down the loss of kidney function and there will be fewer complications,’ Katja Cardol explains…

Description of 20th century changes in the Dutch flora: Description and interpretation (1999 - 2005)

A vitamin D deficiency is often associated with smoggy English industrial cities during the Industrial Revolution, but research carried out on skeletons now suggests that the ‘English disease’ was also prevalent in rural areas of the Netherlands. Doctoral defence on 29 January.

During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

The research master's specialisation Clinical and Health Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.

PhD defence

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

PhD defence

PhD defence

How can zebrafish research help understanding human diseases?

Trail, FGGA’s internship platform will be one-year old in November. In the upcoming weeks, we will be interviewing some FGGA students who went on internships. What did they learn from their internships? And what tasks were assigned to them?

In the MS Cognitietour, psychologists and neuroscientists from Leiden University discuss the latest scientific knowledge with MS patients and their loved ones. This leads to insights: 'One lady told how much stress she felt from all those caregivers around her bed.'

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

What is the role of auxin in the initiation and process of somatic embryogenesis?

As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.

Promotor: Prof.dr. M. Danhof

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

Many of the challenges of our time are too complex to be resolved within the confines of a single discipline. Leiden University is a broad-based university where an incredible number of research fields converge. That makes us the ideal breeding ground for, and practitioners of, interdisciplinary research…

The Biomedical Sciences Master programme in Leiden will help to deepen and broaden your understanding of human health and disease. We provide you with a challenging and flexible programme in a personalized environment.

The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?

Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.

Supervisor: Anna Vlachodimou

As far as Daniël Pijnappels, Professor of Cellular Electrophysiology, is concerned, both researching and inventing are essential for a scientist.

To underline the urgency: Our faculty faces a significant financial challenge. With a structural reduction of €5 to €6 million in annual income, dark clouds are gathering on the horizon. Added to this are the uncertain consequences of budget cuts from The Hague, including the Balanced Internationalisation…

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

A new health programme will reward patients with - or at risk of developing - cardio-vascular diseases for keeping to a healthy lifestyle. A research group including psychologist Andrea Evers has been awarded 2.5 million euros by the Dutch Heart Foundation and the Ministry of Public Health, Welfare…

Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?

Together with patient representatives, clinician-researchers from Radboucumc (Internal Medicine) Amsterdam UMC and researchers from Leiden University (Andrea Evers and Henriët van Middendorp) have received the Medical Inspirator Prize 2019 of The Netherlands Organisation for Health Research and Development…

What is the role of cell wall-deficiency in the persistence of tuberculosis?

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

The Leiden University Medical Center (LUMC) will start construction this year of the largest non-profit stem cell and gene therapy facility in the Netherlands, and one of the largest facilities in Europe. NECSTGEN – the Netherlands Center for the Clinical Advancement of Stem Cell and Gene Therapies…

As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

Which plant leaf characteristics are involved in thrips resistance in tomato?