Can new variants of daptomycin and the polymyxins be found?

Supervisor: P.J.J. Hooykaas

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

Promotor: B. van de Water

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

Promotor: Prof.dr. J. Memelink

PhD defence

The applications of studying the early development of insects range from agriculture to material science.

The programme group Research Methods and Statistics offers support to researchers from a variety of research projects within Education and Child Studies.

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…

“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”

PhD defence

PhD defence

PhD defence

What is the role of stress and stress-related hormones in emotion regulation?

The Leiden Slavery Studies Association (LSSA) is dedicated to promoting a greater understanding of slavery and post-slavery in any period and any geographical region.

A novel in vivo model system for studies on glucocorticoid resistance

ASLU 14

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Are you thinking about studying Book and Digital Media Studies? Learn more and watch the introduction video.

Are you thinking about studying Film and Photographic Studies? Learn more and watch the introduction video.

Discovery of metastasis promoting candidate drug targets

We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Welcome to the website of Turkish Studies at Leiden University. On this website you will find information on the work and the activities of the people studying the Ottoman Empire and Turkey at Leiden University.