1,180 search results for “computational modelling” in the Public website
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Gerard van Westen: 'Our model predicts what candidate drugs do in your body'
He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…
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A New Model of Global Governance in International Tax Law Making (GLOBTAXGOV).
Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.
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Through the hands of signers: modeling spread and change in historical sign language linguistics
How do sign languages change and spread over time, and how is this influenced by their transmission history?
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Celebrating female computer scientists: ‘Computer science is for everyone’
Four female computer scientists share a common goal: to showcase the significant contributions of women in computer science and inspire their students. Together, they are organising this year’s Alice & Eve event, a one-day symposium dedicated to celebrating women in computer science. The event, scheduled…
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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Advances in Cardiac Computed Tomography Angiography and Characterization of Cardiac Disease
PhD defence
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European Experts in Inflammation: from the molecular players to animal models and the bedside
How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Flow through EMT Facilities Applying Dynamic Behavioral Simulation Models
This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…
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A monodromy criterion for existence of Neron models and a result on semi-factoriality
In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.
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Innate immunity, developmental speed and their trade-offs in two hexapod models
This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.
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Light on the quantum computer
Physicist Martin van Exter works with light at nanoscale, at the forefront of nanocomputer research. But as Director of Education he also has a vision for physics teaching. Inaugural lecture 18 November.
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Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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Catherijne Knibbe
Science
c.knibbe@antoniusziekenhuis.nl | +31 71 527 6329
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High-field neuroimaging of computational processes that drive cognitive control.
How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?
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New practice tool for quantum computer coding: OpenFermion
In a global effort, quantum computers are rapidly being developed. In the meantime, researchers have to learn how to write code for these devices, which are fundamentally different from conventional computers. A collaboration of scientists led by Google, and including physicists from Leiden and Delft,…
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Models of curves: The Birch and Swinnerton-Dyer conjecture & ordinary reduction
Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Accurate modeling of the dynamics of dissociative chemisorption on metal surfaces
Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.
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Patient-derived models of breast cancer: A breakthrough story of the duct
PhD defence
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Vascular tumor of bone and related lesions; from gene fusions to tumor models
PhD defence
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Champion in headwind and predictions
It is a stormy Sunday afternoon, with gusts of a whopping 110 kilometres per hour. Chemist Teun Sweere defies the enormous headwind on his city bike and wins the NK Headwind cycling after 22,5 minutes. A new highlight follows six months later: his PhD defence (14 June).
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Computer scientists from Leiden and Eindhoven optimise building designs
The design process of new buildings is extremely complex due to strict requirements. Computer models are used to create the designs. Scientists from LIACS developed advanced algorithms that help their colleagues at Eindhoven University of Technology to optimise these models.
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Astrophysical plasma modeling of the hot Universe: Advances and challenges in high-resolution X-ray spectroscopy
Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.
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Solid State NMR and modelling of photoinduced energy and electron transfer
Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…
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Alina Karakanta
Faculty of Humanities
a.karakanta@hum.leidenuniv.nl | +31 71 527 2978
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Felix Frohnert
Science
f.frohnert@liacs.leidenuniv.nl | +31 71 527 2727
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Joost Batenburg
Science
k.j.batenburg@liacs.leidenuniv.nl | +31 71 527 6985
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Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation
On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.
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signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Tackling messy blood vessels to fight cancer
With a Vici grant of 1.5 million euros, Professor of Mathematical biology Roeland Merks will look for ways to fix messy and leaky blood vessels in tumours. His research combines mathematical simulations and lab experiments in a unique way.
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Meta‐modelling: development of methods and tools for the exchange, analysis and communication of anonymised patient data
This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…
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Keyhole limpet hemocyanin challenge model for studying adaptive immune system responses in early-phase clinical drug development
PhD defence
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predictive pharmacology in children using semi-physiological population modelling: application to hepatic metabolism
Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…
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New memory developed for superconducting computer
If computers work on superconducting current, they won’t consume any energy. Leiden physicists have now gained control over a new type of superconducting memory elements. Publication in Nature Communications.
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Simon Marshall
Science
s.c.marshall@liacs.leidenuniv.nl | +31 71 527 2727
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Xaver Funk
Faculteit der Sociale Wetenschappen
s.x.funk@fsw.leidenuniv.nl | +31 71 527 2727
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Philipp Kropf
Science
p.kropf@cml.leidenuniv.nl | +31 71 527 2727
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Carlo Beenakker
Science
beenakker@lorentz.leidenuniv.nl | +31 71 527 5532
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Peng Sun
Science
p.sun@cml.leidenuniv.nl | +31 71 527 2727
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Hanneke Leegwater
Science
h.leegwater@lacdr.leidenuniv.nl | 071 5276274
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Next quantum computer comes to the Netherlands
Europe's latest quantum computer is set to arrive in the Netherlands. The Dutch IT cooperative, SURF, which supports education and research institutions, has secured funding from the European EuroHPC programme to make this possible. Researchers from Leiden University will play a key role in the project,…
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A PCAD-model for fish to study the impact of airgun sound exposure on free-ranging cod
We are developing the conceptual framework, which is new to this taxonomic group, and evaluate the current state of the art with respect to all critical parameters and transfer functions for a fully developed Population Consequences of Acoustic Disturbance (PCAD) model.
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NWA funding for communications research on quantum computing
Leiden physicist Julia Cramer receives 50 thousand euros in funding for 'Let's talk about quantum', a research project on communication about quantum computing. A project for high school students by education expert Henk Buisman is also included in the NEWA ELSA funding.
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Michael Lew explores how computers can see
Learning how computers can process and describe images just like human beings do. It is one of the key elements of the research of Michael Lew, who sees Deep Learning as a promising way to achieve this goal. On the 1st of January 2021, he was appointed Professor of Deep Learning at the Leiden Institute…
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regular and deuterated water in space: a combined laboratory and computational study
Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: H.M. Cuppen, S. Ioppolo
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Medical Delta AI for Computational Life Sciences
The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?
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distribution affects permeability barrier function of stratum corneum lipid model membranes
Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463
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Simon Portegies Zwart
Science
spz@strw.leidenuniv.nl | +31 71 527 8429