Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Both the Dutch government and the European Commission dedicate an increasing share of public funding for research and innovation to mission-oriented programs, aiming to facilitate sustainability transitions. These programs typically involve support fora range of different research activities, from the…

Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…

The state of our environment is a global concern. Despite an increasing awareness, setting internationally binding and ambitious commitments has proven to be a very difficult process. Can unilateral trade measures form an alternative and contribute to global environmental protection?

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Key publications of the Barz Lab

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

The Leiden Institute of Advanced Computer Science (LIACS) offers bachelor and master level education in computer science at Leiden University. We are known for our scientifically based education and for our open atmosphere.

Lu, Man defended his thesis on 28 September 2017.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

The topics of discussion included multiple choices questions, research on teaching, workload and many other things. On 29 October four new enthusiastic fellows were installed in the Leiden Teachers’ Academy and presented their research innovation projects.

All acute care staff at Leiden University Medical Center have received their first and sometimes even their second dose of the coronavirus vaccine. But how long will you be protected after vaccination and what does the genetic material of the virus do in the vaccine? Our virologists Ann Vossen and Leo…

As a graduate of the Faculty of Humanities, there are unlimited possibilities. Do you want to know more about the sectors and jobs Humanities' graduates end up? Click on the name of the alumna/alumnus to read their story!

The Mathematical Institute has a rather liberal management structure. Tasks and responsibilities are distributed among the staff. Important decisions are taken by consensus. Various organisational divisions are featured below.

Leiden University Medical Center (LUMC) and the Centre for Human Drug Research (CHDR) are taking part in the phase 2 clinical trial of Janssen Vaccines’ candidate coronavirus vaccine. The vaccine will be tested on 45 test participants in Leiden from 14 September onwards.

Are AI models such as Midjourney violating artists' copyright? Dirk Visser, Professor of Intellectual Property Law, spoke about this topic on Dutch current affairs news programme 'NOS Radio 1 Journaal' .

There are currently two projects in Coptic Studies that are supported by the NVIC. Both are directed by Dr. Karel Innemee and both take place in the Wadi Natrun.

In a lot of research on education, general didactic principles are applied to a particular area of study. ‘But every field of study also has its own ways of thinking’, argues professor Fred Janssen. ‘If you can identify those ways of thinking, then you have a lot of indicators for how you can best organise…

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

Below you can read about studies we have carried out in the past.

In the large gas clouds between the stars, chemical reactions take place under extreme conditions, giving rise to both small molecules, such as water and common salt, as well as large complex molecules that can serve as the building blocks of life. This is known as astrochemistry and it is something…

The Mycenaean civilization of ancient Greek times offers enormous potential for useful information: from innovative construction methods to ways of handling crisis situations as a society. Archaeologist Ann Brysbaert and her team analyse Mycenaean construction processes in the ERC Consolidator project…

Are you interested in the minor Public Administration: Multi-Level Governance? Find out more about admission and application below.

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands

Are you the scientist of the future? Come experiment with science at the Experiments Square! Make your own slime, discover how rubber can count, play along with the antibiotics game, discover the power of light and much more!

Managing scarcity to serve the public interest is a classic government task. An important way to execute this task is by allocating individual rights that are only available in limited quantities, such as CO2 emission allowances, gambling licences, subsidies, radio frequencies, public contracts and…

Onderwijs omvat wiskunde, informatica en data science, astrofysica, natuurkunde, chemie tot bio-farmaceutische wetenschappen, biologie en milieukunde.

The programme is structured along learning lines on environmental sustainability, governance and skills.

The master's specialisation Social and Organisational Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

In the track Governance of Crisis, you will be familiarized with the main body of knowledge on strategic crisis management.

Water, Urbanism, and Sustainability in Roman Ostia

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

How can teachers be motivated by their students’ data in making stepwise changes to their teaching practices?

From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

The information below concerns courses that our group teaches in Leiden. 

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.