776 search results for “target therapy” in the Public website
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Immuno-photodynamic therapy of cancer
PhD defence
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Cool little kids
Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Leiden Index of Depression Sensitivity
The Leiden Index of Depression Sensitivity (LEIDS) measures cognitive reactivity (CR) to sadness, an aspect of cognitive vulnerability to depression, conceptually similar to rumination.
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An online self-help programme for people with HIV and depressive symptoms
To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.
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Why study 'Transfusion Medicine and Cellular and Tissue Therapies' at Leiden University and the Autonomous University of Barcelona?
The collaboration between Leiden University (Medical Center) and the Autonomous University of Barcelona forms one of the most powerful international alliances for the creation and transmission of knowledge in the field of transfusion medicine.
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Stromal cells suppress immune response symptoms
A new therapy for the serious Graft-versus-Host disease
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft
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New professor wants to improve care for sarcoma patients
Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Sylvestre BonnetScience
bonnet@chem.leidenuniv.nl | +31 71 527 4260
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Strategy
The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.
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Antithrombotic therapy in the Netherlands- New insights from nationwide data
PhD defence
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Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
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Partners
Our research programme collaborates with all kinds of partners to achieve our goal: bringing scientific discoveries to the clinic as soon as possible.
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In vivo tracking and biodistribution of protein aggregates
Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…
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Predictive value of semi-physiological models for clearance of renally excreted drugs across the paediatric age range
The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Information activities
Get to know us through our online events for prospective students!
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Stefano Coppola Receives AXA RF Fellowship to Study Pancreatic Cancer
Leiden biophysicist Stefano Coppola has received the prestigious AXA Research Fund postdoctoral fellowship. With this grant he can work for two years on a project to research the role of mechanical factors in the development of pancreatic cancer.
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GMP facility for innovative drugs (KFT-J10 / IGFL)
The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.
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Biologics Formulation
A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…
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Career prospects
This Master enables you to practice professional activities such as: lead research projects and develop technically qualified projects in the field of transfusion medicine.
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Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
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Rare-earth nanoparticles in bioimaging and therapy
PhD defence
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Improving PTSD treatment for adults with childhood trauma (IMPACT-study)
The aim of this project is to investigate the (cost)effectiveness of two innovative forms of trauma-focused therapy for patients with childhood abuse related PTSD. The ultimate goal is to improve quality of care and contribute to treatment innovation for this severely ill target population.
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Projects
An overview of Quantitative Pharmacology projects
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Book Learn to Dare/DDD
In 2008, the intervention ‘Denken + Doen = Durven’ (Think + Do = Dare) was developed in the Netherlands (Bögels, 2008). This is a cognitive behavioral therapy program for children and young people between the age of 8 to 18, diagnosed with an anxiety disorder. The intervention is given by a professional,…
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Clinical Psychology
Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.
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BioTherapeutics (MSc)
The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…
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Controlling anxiety in late life (CALL)
Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…
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In search of synergy: novel therapy for metastatic uveal melanoma
PhD defence
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Clinical pharmacometrics to optimize immunosuppressive therapy in kidney transplantation
PhD defence
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Immune modulation and monitoring of cell therapy in inflammatory disorders
PhD defence
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Viral gene therapy approaches for CRB1 retinal disease
PhD defence
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Novel regenerative therapies for the adaptive immune system
PhD defence
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Elise Dusseldorp: ‘Algorithms can see whom a treatment will work for’
Imagine how much time, money and discomfort it would save: a personalised treatment for each individual patient. Precision medicine like this is coming ever closer, thanks in part to Elise Dusseldorp’s algorithms. They retrieve a wealth of information from research data.
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Research Paradigms and Instruments
Our team is involved in the translation and adaptation of several questionnaires, for research purposes. Information about each questionnaire is listed below.
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Career prospects
A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.
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Erik DanenScience
e.danen@lacdr.leidenuniv.nl | +31 71 527 4486
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Targeting Inter-Organ Cross-Talk in Cardiometabolic Diseases
PhD defence
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Registration Co-Align 2023
Registration for the Co-Align 2023 conference is open!
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Immunity, Infection and Tolerance
The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.
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Silicon pore optics for high-energy optical systems
This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.
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Immunotherapy to limit atherosclerosis-projects
For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.
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Quantitative pharmacology approaches to inform treatment strategies against tuberculosis
Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?