2,242 search results for “system cell transplant” in the Public website
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Véronique Ongenae
Science
v.m.a.ongenae@biology.leidenuniv.nl | +31 71 527 5075
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Treosulfan pharmacokinetics and dynamics in pediatric allogeneic stem cell transplantation
PhD defence
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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glucocorticoid and mineralocorticoid receptor signaling in the innate immune system
Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers
What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?
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Martin Moerings
Faculteit Rechtsgeleerdheid
l.m.moerings@law.leidenuniv.nl | +31 71 527 2727
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Wenyu Wan
Faculteit der Sociale Wetenschappen
w.wan@fsw.leidenuniv.nl | +31 71 527 2727
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Research into the academic system
Research into research improves the academic system. CWTS studies and evaluates the academic system in various ways. One way is to provide information on the productivity and impact of academics by documenting how many publications they or their universities produce and how often these publications…
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Crossed product algebras associated with topological dynamical systems
Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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TRIPS: Thrips Reduction In Production Systems
Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.
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Christine Mummery
Faculteit Geneeskunde
c.l.mummery@lumc.nl | +31 71 526 9300
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Tessa Vergroesen
Science
t.m.vergroesen@biology.leidenuniv.nl | +31 71 527 4912
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Proper and improper uses of MCDA methods in energy systems analysis
In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Systems pharmacology of human neuroendocrine disease entities
An important hormone excreting gland in the human body is the pituitary
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Cells ‘walk’ to firm ground
A new mathematical model may explain how body cells get their shapes and what makes them move within a tissue. The model provides fundamental knowledge for applications in tissue engineering, amongst other things. Publication in open-access journal iScience.
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Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
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self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
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Aggressiveness of cancer cells halted
Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.
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Chaotic dynamics in N-body systems
Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie
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Exploration of the endocannabinoid system using metabolomics
To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.
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Mining Sensor Data from Complex Systems
Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe
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Mathematical analysis of systems pharmacology models
Systems pharmacology aims to apply techniques from systems biology to pharmacological models.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Chemical biology of antigen presentation by MHC molecules
MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.
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Astrochemistry and the Origin of Planetary Systems
Dishoeck
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Making cells ultra-heavy
The life of a fibroblast is heavy, but PhD student Julia Eckert makes it 19.5 times heavier, using the Large Diameter Centrifuge at the ESTEC space research centre in Noordwijk.
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Periodic pulse solutions to slowly nonlinear reaction-diffusion systems
Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher
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T-cells more important in the fight against the COVID-19 virus than initially thought
A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…
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Systems pharmacology-based translational drug pharmacokinetics
High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.
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Counting Molecules in Living cells
Biophysicist Rolf Harkes has developed a microscope to optically localize individual molecules in living cells. It improves monitoring of diseases like cancer and Parkinson’s at the cellular level. Defende PhD thesis on t13 January 2016.
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Large Time Behaviour of Neutral Delay Systems
Promotor: S.M. Verduyn Lunel
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The Tocharian Gender System: A Diachronic Study
On the 23rd of March, Alessandro del Tomba successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Alessandro on this achievement!
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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ERC Starting Grant for Roxanne Kieltyka: stem cells in gels
Chemist Roxanne Kieltyka has received an ERC Starting Grant of 2 million euros. In her lab, she creates gels that mimic the instructive material that supports cells in our body. With the grant, she aims to make these gels stiff and tough, and to create a bio-printed miniature heart ventricle.
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Experimental Systems: Future Knowledge in Artistic Research
The experimental approach of science applied to artistic research
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Erik Danen
Science
e.danen@lacdr.leidenuniv.nl | +31 71 527 4486
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Noortje Dannenberg
Science
n.dannenberg@biology.leidenuniv.nl | +31 71 527 5075
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Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification
On 29 January 2019, Robbert van Eijk defended his thesis 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. The doctoral research was supervised by Prof. dr. H.J. van den Herik.
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Researchers reveal how stem cells make decisions
Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…
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Labor movements and party system development: Why does the Caribbean have stable two-party systems, but the Pacific does not?
How can we explain that Caribbean small states have the most stable two-party systems in the world, while Pacific small states have either very weak parties or no parties at all? Matthew Louis Bishop (University of Sheffield, UK), Jack Corbett (University of Southampton, UK) and Wouter Veenendaal (Leiden…