3,353 search results for “system cell biology” in the Public website
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microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice
The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…
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lic-acid)-based particulate vaccines: particle uptake by dendritic cells is a key parameter for immune activation
Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…
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Improving the filamentous fungus Aspergillus niger as cell factory for starch degrading enzymes
We aim to develop A. niger strains that produce more starch degrading enzymes even in the absence of starch.
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
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Concurrent Systems
In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar
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Development of novel metabolomics and systems pharmacology methods
We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).
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Systems microscopy-based drug target discovery in pathogen-meidated inflammatory respons signalling
Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Systems & infrastructure
Here are some systems and infrastructures that are useful to students.
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Bacteria under stress can live without cell wall
Thread-like bacteria make cells that no longer have a cell wall under the influence of osmotic stress. A remarkable discovery, since the cell wall serves as a protection barrier for bacteria. It could also help to explain how pathogenic bacteria can hide in our body from our immune system. A team of…
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Kees Musters
Science
musters@cml.leidenuniv.nl | +31 71 527 7461
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Louie Krol
Science
l.krol@cml.leidenuniv.nl | +31 71 527 2727
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Shana Hepping
Faculty Governance and Global Affairs
s.l.hepping@fgga.leidenuniv.nl | +31 70 800 9500
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Latency, Energy, and Schedulability of Real-Time Embedded Systems
Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.
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Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
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Understanding membrane fusion at the molecular level using a biomimetic model system
How can the transport of molecules in living cells help to target medicines at exactly the right place?
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Leiden scientists map cell types in fetal kidney
Kidney failure is a serious issue because kidneys cannot regenerate themselves after injury. A possible solution consists of artificially growing healthy kidney tissue. To achieve that, scientists first need to understand kidney development during the earliest stages, in the fetus. Leiden researchers…
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The international tax system as a complex system
Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Education system
Every year, Leiden University welcomes some 27,000 students from 115 different countries. In educating these students, we are committed to ensuring that the quality of our tuition meets or exceeds the highest-possible standards.
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Silva Nova – Restoring soil biology and soil functions to gain multiple benefits in new forests
We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…
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Analysis of Energy Systems
The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.
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Cells ‘walk’ to firm ground
A new mathematical model may explain how body cells get their shapes and what makes them move within a tissue. The model provides fundamental knowledge for applications in tissue engineering, amongst other things. Publication in open-access journal iScience.
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Marc Spijker
Science
spijker@math.leidenuniv.nl | +31 71 527 2727
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Onno van Gaans
Science
vangaans@math.leidenuniv.nl | +31 71 527 7122
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Hermen Jan Hupkes
Science
hhupkes@math.leidenuniv.nl | +31 71 527 5587
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Arjen Doelman
Science
doelman@math.leidenuniv.nl | +31 71 527 7123
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Marcel de Jeu
Science
mdejeu@math.leidenuniv.nl | +31 71 527 7118
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Development & Disease
Development & Disease is one of the four research themes of the Institute of Biology Leiden.
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Joost Beltman
Science
j.b.beltman@lacdr.leidenuniv.nl | +31 71 527 4323
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Systems and Security
Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…
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modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Systems Modelling Lab (SML)
Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.
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System Verification Lab (SVL)
The correctness of computational systems is of great importance to our society, since it becomes ever more reliant on the benefits of computing.
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Systems and security
Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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poly(i:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity
For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Mathematics-based strategies for repairing tumour blood vessels
How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?
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Aggressiveness of cancer cells halted
Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.
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Next generation human IPSC-derived reporter systems for image-based analysis of drug adversity
Analysis of drug adversity
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Chengyi Liu
Science
c.liu@cml.leidenuniv.nl | +31 71 527 2727
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Leiden study system
Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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New insight into immune cell behaviour offers opportunities for cancer treatment
An international group of scientists has discovered that certain cells of our immune system – the so-called T cells – communicate with each other and work together as a team. To fight an infection they stimulate each other’s growth, but at the same time, they inhibit each other when there is a surplus…
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Synthesis of phosphodiester-containing bacterial cell wall components: teichoic acids, capsular polysaccharides and phosphatidyl glycerol analogues
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
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Advanced Computing and Systems (MSc)
The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.
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Frank Schaftenaar
Science
f.h.schaftenaar@lacdr.leidenuniv.nl | +31 71 527 5134