PhD defence

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…

Identifying natural plant-associated bacteria that provide targeted inhibition of pathogens through the production of antimicrobial peptides.

Osteoarchaeologists help forensic scientists solve crimes. They also study bone material from the Second World War in order to identify victims.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Peak Performance: Collaborative Crisis Management Before and During International Summits. This comparative case study probes into conditions for collaborative governance in the security organisation of international summits.

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

Mark Klaassen presenter at the Reuniting Families: From Access to Integration event organized by the EU office of the Red Cross in Brussels.

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.

On 15 February 2022, Morshed Mannan defended the thesis 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. The doctoral research was supervised by Prof. I.S. Wuisman and Prof. J.A.A. Adriaanse.

Did early farmers deliberately use animal manure on their fields?

Since the adoption of agriculture people have cultivated fields. The project concerns all kinds of aspects related to raising crops.

Projects in the department of Environmental Biology

A special relationship between plants and fungi, which plays an important role in carbon storage in soil, has the potential to slow down climate change. However, the amount of carbon stored in soil is decreasing as a result of human activity. This is what researchers say in a publication in Nature Communications.…

Stratigraphy, Palaeoenvironment and Archaeology of the Middle and Late Pleistocene Deposits.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

The aim of this study is to further develop the Open Science Monitor, which started as a pilot study.

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

PhD defence

Inaugural lecture

Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…

The wealth of shoes, sandals and other footwear from ancient Egypt is poorly understood due to lack of research. This is remarkable, because from the very beginning of Egypt’s long history footwear served practical as well as more spiritual purposes.

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

In the fall of 2021, Cleveringa professor Roméo Dallaire and world experts shared their thoughts about PTSD, children’s rights, war crimes, humanitarian law, and peacekeeping in a series of conversations about leadership and moral dilemma during times of conflict and crisis.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: Prof.dr.ir. T.H. Oosterkamp, N. de Jonge

The worldwide race to the quantum computer is in full swing. This computer can take on computing tasks that we can only dream of today, such as finding proteins that can be used as medicines in seconds flat. Leiden physicists have discovered how the Majorana particle can be used as a building block…

PhD defence

Following the Beirut explosion, BBC's podcast series The Foodchain explores the chemical that caused the blast: ammonium nitrate. A compound that is widely used to produce fertilizer. Professor of Environmental sustaibability Jan Willem Erisman tells about the effects of nitrogen on the environment.

PhD defence

What are the key issues in conducting LCA of bioenergy systems? What is the environmental sustainability status of second generation bioethanol? How much would the final results of biogenic carbon neutrality assumptions deviate from the true values based on a complete inventory? How to assess the impact…

PhD defence

PhD defence

PhD defence

The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…

How can we quantify the density of species within a community through environmental DNA concentrations?

Today’s socio-economic challenges aren’t new. In the centuries after the retreat of the Roman state people with different backgrounds and with different ways of life somehow managed to build and maintain a complex economic system in northern Gaul that would produce the ruling dynasties of Europe. By…

Biodiversity is under pressure worldwide, but is essential for our health, food security and well-being. What is the influence of human actions on ecosystems? Can we provide biodiversity-inclusive solutions for our key societal challenges? These questions are central to the Biodiversity research the…

PhD defence

Supervisor: P.J.J. Hooykaas

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.

The book ‘Pesticides and the Environment’ gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

It is well-known that humans have significantly transformed ecosystems since their adoption of agriculture. However, in a deeper past, prehistoric hunter-gatherers may already have altered and modified their niche in ways that had major impacts on ecosystems.

Corrie Bakels & Hans Kamermans (eds) (2009)