The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…

PhD defence

The potential of liposomal cancer vaccines

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

Homicide engenders broad moral concerns in society, and its aftermath can be understood as a barometer for criminal justice policy. Of all homicides committed, however, only some lead to arrest, to prosecution and ultimately to conviction in court.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Lodewijk Petram, author of the book 'The World's First Stock Exchange', discussed the rise of the Amsterdam stock exchange in the 17th century in the ninth Hazelhoff Guest Lecture.

Proceedings of the Eighteenth Annual Theoretical Roman Archaeology Conference Amsterdam 2008

What is Interaction between Legal Systems (ILS) and what does it entail as research profile area at Leiden Law School? More on this at the kick-off event of ILS 2.0. This will take place on Wednesday 26 October 15.00 – 17.00 in the Grotiuszaal (A051 KOG). The afternoon will be closed with drinks at…

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

PhD defence

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

What is the origin of solar systems?

On 5 October, Katherine Filesia defended the thesis 'Speaking the same language: the introduction of the Anglo-American trust into the Dutch legal system'. The doctoral research was supervised by Pim Huijgen and Frans Sonneveldt.

The languages of the Mbam-et-Inoubou District of the Centre Region of Cameroon have a unique position in Bantu linguistics. Being in between

Promotor: Prof.dr. M. Danhof

Across Europe, the need for a more dynamic governance and a better societal integration of research and innovation is increasingly appreciated. Internal drivers of change (such as the digitalization of science) and political will to better align with societal needs and concerns are bringing about aspirational…

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

This doctoral thesis comprises four studies on the content and structure of physics teachers’ belief systems about teaching and learning physics in secondary education in the Netherlands.

Promotor: Prof.dr. L.J. Slikkerveer

Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Bert Fraussen and Valérie Pattyn theoretically contribute to the existing literature on policy advice by drawing inspiration from niche theory.

Promotor: A. Kros

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: B. van de Water

With the recent rise and fall of IS, academics and policy makers around the world are expressing concerns about the fate of children of former foreign fighters. Will they follow in their parents’ footsteps? In this paper, Layla van Wieringen, Daan Weggemans and Marieke Liem argue that in light of this…

van Luijk

What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

In this paper, Sarah Giest and Bram Klievink highlight the effects of AI implementation on public sector innovation. This is explored by asking how AI-driven technologies in public decision-making in different organizational contexts impacts innovation in the role definition of bureaucrats.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.