Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

Don Scott De Amicis will give the sixth Hazelhoff Guest Lecture on international development finance: challenges and opportunities.

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

On 19 December 2019, Reza Eftekhar defended his thesis 'The Role of the Domestic Law of the Host State in Determining the ratione materiae Jurisdiction of Investment Treaty Tribunals: The Partial Revival of the Localisation Theory'. The doctoral research was supervised by Prof. E. de Brabandere.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Matthias Haentjens, Jouke Tegelaar and Dorine Verheij have recently published the chapter Financial Market Regulation and Supervision in the new volume of the prestigious The Law of the European Union (previously Kapteyn and VerLoren van Themaat).

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

In the Leadership Lab (4 EC) you tackle a topical problem presented by one of our partner organisations and develop important leadership skills in practice.

Restructuring and insolvency laws play a pivotal role in addressing the often conflicting interests of stakeholders of financially distressed companies. Whereas financial distress is an inherent risk of entrepreneurship in market-based economies, legal tools serve an important role to ensure an orderly…

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

International trade plays a critical role in global food security, with global consumption having highly localized environmental impacts.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

In this thesis, we present new laboratory data of interstellar dust analogues.

What are the phylogenetic relationships among the members of speciation bursts?

If we want to solve global problems, we need to know about both the theory and the practice. How does the international community make decisions about military intervention, for instance? Why is it such a complex process? Professor Herman Schaper has represented the Netherlands at the United Nations…

How should European financial law best integrate considering the interaction of the relevant legal systems?

This 48-month project is to contribute to a solid, accessible, domestically owned knowledge base for people-centred interventions aimed at strengthening access to justice in Libya (A2JiL), and to disseminate such knowledge among stakeholders, enhancing awareness and the capabilities required to provide…

Physics and Engineering Approaches to Biomedicine and Pharmacology

The Aesernia Colonial Landscape project investigates ancient settlement patterns and dynamics around modern Isernia in Molise (Italy), the Latin colony of Aesernia (founded 263 BC). It consists of intensive systematic field survey in the territory of the colony, combined with remote sensing and geoprospection…

This PhD project develops and applies a GIS procedure to use legacy survey data in settlement pattern analysis. As part of the research by the LERC project (NWO, Leiden University, KNIR), legacy data produced by surveys in central and southern Italy are examined in a comparative framework to investigate…

The aim of this project is to foster a historiography that does justice both to the realization that scientific knowledge is constructed by local, contingent, and contextual processes, and the claims of science to objective validity.

Leiden University’s Master of Laws in Advanced Studies in Law and Finance (L.L.M.) examines the complex, international and multidisciplinary area of law and finance: markets, regulation and a sustainable society.

The core curriculum equips students with the conceptual approaches and qualitative empirical research methods necessary to analyze law in context. Specialized electives enable students to dive deeper and focus on particular areas of legal practice—from legal mobilization to regulation and compliance…

This study aims to provide a long time perspective of human landscape manipulation. Studying the roles of prehistoric foragers in past ecosystems is of great importance to establish the character of past 'natural' landscapes and to enhance the management of current ones.

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

What is the role of cell wall-deficiency in the persistence of tuberculosis?

Submitted manuscripts will be subject to blind peer review.

An effective and equitable approach to resource conflicts?

This research cluster is a part of the Institute of Political Science’s research programme ‘Institutions, Decisions and Collective Behaviour’. Its members study the design and functioning of Dutch political institutions as well as attitudes and behaviour of political elites and citizens.

On 1 December 2020, Bernadette Muscat defended her thesis 'Insolvency Close-out Netting: A comparative study of English, French and US laws in a global perspective'. The doctoral research was supervised by Prof. M. Haentjens and Prof. B. Wessels.

The Darién region of Panama is the only land bridge connecting North, Central and South America. Nowadays home to descendants of African enslaved peoples, Indigenous peoples (Emberá, Wounaan, and Guna), and mestizos, Darién has been and still is fundamental to connectivity, cultural interchange, and…

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

Our researchers form a unique and interdisciplinary team who are active in various fields.

The 2012 crisis in Mali, where the state collapsed and terrorist groups took over the north, came as a surprise to many. Mali had been considered a poster-child for democracy and was judged as considerably more stable than its neighbors by leading quantitative indices of state fragility. This article…

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

Dishoeck

Choice is at the very heart of politics. War or peace, left or right, liberty or security, sovereignty or integration, consensus or conflict: choices matter. Study power and politics as they impact everyday lives in a topranked, selective programme. By doing a master's in Political Science in Leiden…

Research in Leiden University’s Institute of Political Science focuses on the dynamics and the interaction of political institutions, individual decision-making, and collective behaviour.

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.