Three speakers, three fascinating science stories and a well-filled lecture hall. The Niko Tinbergen Lecture had a successful restart on 10 December 2019.

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

How can zebrafish research help to understand and fight human cancer?

Of the 109 Spinoza Prizes that have been awarded since 1995, 26 have gone to researchers from Leiden University. The NWO Spinoza Prize is the highest Dutch award in science. The younger NWO Stevin grant goes to researchers who have achieved great success in the field of knowledge utilisation for society.…

Transferring poo from healthy donors to the intestines of chronically ill people has beneficial effects on these recipients’ gut bacteria, also in the longer term. This is the conclusion of research by the Leiden University Medical Center (LUMC) and the Netherlands Donor Feces Bank (NDFB).

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

The Role and Effectiveness of the G20. In this article, published in The Changing Global Order part of the United Nations University Series on Regionalism book series, author Jaroslaw Kantorowicz discusses the evolution of the G20.

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Promotor: Prof.dr. G.P. van Wezel

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 148-148 (2015) ISBN: 0142-5463

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Implementing all kinds of change and introducing new structures, far-reaching rules and administrative systems may sometimes seem to distract an organisation from its purpose. Furthermore, there is growing recognition of the need of staff of public organisations to find more meaning in their work: the…

Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…

BACKGROUND: Explant human skin equivalents (Ex-HSEs) can be generated by placing a 4mm skin biopsy onto a dermal equivalent. The keratinocytes migrate from the biopsy onto the dermal equivalent, differentiate and form the epidermis of 1(st) generation Ex-HSEs. This is especially suitable for the expansion…

From the 11th of May Ewa Snaar-Jagalska has been appointed Professor in the field of cellular tumor biology within the Faculty of Science at the Institute of Biology Leiden. Her research focuses on the cellular tumor biology and human cancer modeling in zebrafish

In the field of Western art music, improvisation has become a much discussed topic. In this interdisciplinary study I argue that in this context, improvisation is not to be seen as a quasi-autonomous skill or art form, but as an aspect of music-making in general.

The monthly ILS Lunch Seminars have slowly developed into somewhat of a tradition. During this seminar series, all researchers from Leiden Law School can present their research and apprehend in a comfortable setting what researchers from other research programs and institutes are working on.

Eelco de Koning takes us on a journey through time. He explains what type 1 diabetes is, how it is currently treated and what the future for patients might look like.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Restoring a natural plant environment on exhausted agricultural lands and in nature areas is difficult. We can speed this up by steering the soils towards the desired situation. This is what Martijn Bezemer, newly appointed Professor of Ecology of Plant-Microbe-Insect interactions at Leiden University’s…

Last Thursday, the final ILS Lunch Seminar of 2018 took place. Irma Mosquera Valderrama, Adrián Grant and Frederik Heitmüller gave two very insightful presentations on Global Tax Governance, part of the EU-ERC project ‘A New Model of Global Governance in International Tax Law Making’ (GLOBTAXGOV).

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

With our research and teaching, we help make the world a better place. We join in the academic and public debate, and seek answers to economic and social issues – not just at the local and regional level but at the global one too.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Geneticist Hans Clevers will give the first Niko Tinbergen lecture new style on 10 December, which is all about stem cells. The young Leiden professors Ariane Briegel and Susana Chuva de Sousa Lopes talk about bacterial noses and the cultivation of egg cells in the lab in short introductory lectures…

Leiden University now offers almost 20 Massive Online Open Courses (MOOCs). The enthusiasm displayed by participants makes it rewarding to develop and teach such courses, say MOOC lecturers Marlies Reinders and Edwin Bakker. But that is not all, ‘You bring together a global community.’

Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…

PhD defence

PhD defence

Former Leiden Observatory PhD candidate Danna Qasim has won no less than two prestigious prizes with her thesis, titled 'Dark ice chemistry in interstellar clouds'. Qasim received the IAU PhD Prize from the IAU. The Astrochemistry Subdivision of the American Chemical Society (ACS) honoured her work…

As of 1 January 2018 Irma Mosquera will be appointed as Associate Professor at the Institute of Tax Law and Economics of Leiden University.

On 30 October 2020, Armin Cuyvers was invited to give the inaugural lecture of the European Legal Studies Centre of the Universitas Indonesia, Jakarta.

Nineteen new Leiden University MOOCs have started this January. Anyone can take part in these online courses varying from combatting terrorism to kidney transplantation.

PhD defence

Conference

Biological chemist Nathaniel Martin is going to test an alternative antibiotic that can combat common resistant bacteria such as MRSA. For this purpose, he will receive 350,000 euros from the NWO's NACTAR programme. ‘We want to know how safe and effective our antibiotic is in a realistic situation.’

This section shows some of the most relevant articles that are also related to the topic of the EUTAXGOV Chair.

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Leiden physicist Julia Cramer receives 50 thousand euros in funding for 'Let's talk about quantum', a research project on communication about quantum computing. A project for high school students by education expert Henk Buisman is also included in the NEWA ELSA funding.

PhD defence

PhD defence

PhD defence

A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.