The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…

Research at the Leiden University Medical Center (LUMC) Department of Pathology shows the power of artificial intelligence (AI) applied to endometrial carcinoma microscopy images. The group of Dr. Tjalling Bosse offers novel insights that could improve diagnosis and treatment of uterine cancer. Their…

Kros

How can zebrafish research help understanding human diseases?

An overview of the research at the Biologics Formulation group

How do nanoparticles bioaccumulate and biodistribute in organisms?

In Quantum mechanics, particles can be in multiple positions simultaneously. Yet, when a measurement is made, the particle is found only in one place. Technology has come to a point where we may design experiments that will tell us how.

Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

The local ordering of atoms at the surface of a metallic particle determines its catalytic activity and selectivity. As energy systems of the future will be based on efficient catalytic conversion of small molecules in closed cycles, we study how structural effects of catalysts can be used to our ad…

Promotor: H.J.M. de Groot

What are the functions of autophagy in the filamentous fungus Aspergillus niger?

The Green algae Chara as model system for intra and inter cellular transport processes.

Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.

Nature is a never-ending source of inspiration for the researchers at the Institute of Biology Leiden (IBL). Based on a better fundamental understanding of nature, they are able to seek solutions in the area of health and biodiversity. The theme of IBL is ‘Harnessing biodiversity for health.’

This project explored the role of material culture, in casu painted plaster and its technologies, in expressing dynamic social identities and in forging complex interwoven human relationships in the context of the Middle to Late Bronze Age of the Aegean and East Mediterranean.

The Kroese-Duijsters Symposia aim to provide researchers from different fields and different career stages to meet in an informal setting, to stimulate discussions and to start new collaborations. The Kroese-Duijsters Symposia started in 2022 and we are pleased to invite you to the 3rd Kroese-Duijsters…

The Physics and Quantum Matter and Optics specialisation is one of the two programmes Leiden offers in experimental physics. The programme can be tailored to individual needs and interests.

The Biological- and Soft-Matter Physics Master specialisation is one of the two programmes Leiden offers in experimental Physics. The programme can to a high degree be tailored to individual needs and interests.

The Horizon 2020 project ImageInLife has started on 1 January, followed by a kick-off meeting at the coordinating University of Montpellier at the end this month. This Marie Skłodowska-Curie training network brings together European groups that work on the imaging of vertebrates and offers fourteen…

Leiden physicists have been awarded 1.5 million euros for developing a hybrid microscope that provided nanometer-resolution. 'The idea is to combine the resolution of electron microscopy with the pros of optical microscopes.'

Moving an electron microscope of 2000 kg is a delicate challenge. The highly sensitive instrument needed to be moved to a new measurement hall, but even a tiny bump could damage it. After a few nerve-racking weeks of preparing the move and reinstalment, the researchers finally have a verdict: the instrument…

White clouds of ice-cold gas flowing across the floor. Magical, but be careful not to freeze your fingers off. We are of course talking about liquid nitrogen and helium. You may have seen the spectacular Freezing Physics science show by the student organisation Rino. But did you know that this commodity…

Freezing bacteria super fast to gain a true-to-nature image of the internal and external structure. Ariane Briegel Professor of Ultrastructural Biology came to Leiden specially to carry out this research. Leiden University is one of the few institutes in the world to have the necessary equipment. Inaugural…

Assistant professor Joost Willemse firmly believes that as a teacher, you’re never done learning. ‘Students ask questions about things you’ve never thought of yourself. Ultimately, that makes you better at your job.’ That’s why he always encourages his students to ask questions. And it’s appreciated:…

Leiden physicists are helping Wageningen plant researchers to study unpredictable plant embryos. For this, they are using a novel two-photon fluorescence microscope, aided by a 30 thousand euro ZonMW grant.

Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.

Vera Meester has won the annual Physics Image Award 2016, with her photo of 'smiling' colloids. The Volkskrant published the picture as Image of the Week.

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

Prof. Dr. Ir. Marin van Heel, Emeritus Professor at the Institute of Biology Leiden (NeCEN), is one of the winners of the “Wiley Prize in Biomedical Sciences 2017”. This annual award is presented to recognize contributions that have opened new fields of research or have advanced concepts in a particular…

Michel Orrit was awarded the Physica prize 2016 for his groundbreaking work on single molecule spectroscopy.

Chemist Irene Groot has been awarded a TA grant. Together with Shell, Leiden Probe Microscopy, DSM Resolve and Utrecht University, Groot will conduct research into catalysts for the production of raw materials and fuels.

Corona be damned, it's high time for the yearly LION Image award! Deadline in a week.

It's time for the 2021 Image Award

Physicists, including Leiden researcher, Sanli Faes, have devised a new technique for studying processes at microscale rapidly and extremely precisely. This new method will make it easier to develop antiviral medication. And it doesn’t stop there. Publication in ACS Nano.

With the necessary measures, researchers restart their work in various laboratories. The Leiden Cell Observatory is one of the places where scientists resume their lab work.

The guardian of our genome, the protein MutS, scans the DNA for spelling errors and makes sure they are corrected. An essential process for our health. Researchers at Leiden University Medical Centre (LUMC) have discovered precisely how this protein works by making MutS visible with cryo-electron microscopy.…

Leiden Physics Poster

The 1st CIGR meeting was held on March 30, 2021, with talks by representatives of all participating groups.

The project has been done in the Quantum Matter & Optics group under the supervision of Prof.dr.ir. Tjerk Oosterkamp.The title of the presentation is:

The project has been done in the Biological Matter group under the supervision of Prof. dr. ir. S.J.T. van Noort and Prof. dr. M.A.G.J. Orrit.The title of the presentation is: ''Characterization of Single Gold Nanorods with Two Photon Microscopy.

Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…

How do bacteria sense and adapt to their environment? Ariane Briegel, Professor of Ultrastructural Biology, is intrigued by this question. Using new techniques, she produces three-dimensional images of bacteria that provide us with new clues about their sensory system.

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

Key research articles and book chapters of the Chromatin group.

Former PhD, Bachelor and Master students of the Van Exter Lab

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

Tracing the residues of Neolithic activities through the study of stone artefacts