474 search results for “infection” in the Public website
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Sugarcoating the search for a new vaccine
A vaccine based on sugar coats does have the potential to combat a multi-resistant staphylococcus. That is what Jeroen Codée and his colleagues from Utrecht state in Nature. In doing so, they are contradicting the earlier conclusions of German colleagues.
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Antibiotic treatments make us more susceptible to negative emotions
People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.
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A unique defence: Bacteria lose cell wall in the presence of virus
Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…
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White blood cells in transparent embryos
Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…
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Close contact between women and dogs in prehistoric times
Close contact between women and dogs in prehistoric times Women and dogs were in close contact in the neolithic age of hunters-fishers-gatherers. This has been suggested by Leiden osteoarchaeologist Dr Andrea Waters-Rist and fellow researchers who have studied a tiny biological fossil. The fossil was…
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Statement on ransomware incident at NVIC
In the following statement we would like to inform you of a ransomware incident at the Netherlands-Flemish Institute in Cairo (NVIC) in which your personal information might have been involved. The University of Leiden administrates this institute. Related to the transition to working from home as…
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Three awarded research projects in NWO-XS call
Cryogenic memories, antibiotic treatment for urinary tract infections and recycling plastic sustainably. These are the subjects of the three NWO-XS grants awarded to Leiden Science researchers.
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The immune system: step it up or slow it down?
When foreign matter enters our body, our immune system has to make a choice whether or not to go on the attack. There are times when the system goes wrong, and we end up with an illness or an allergic reaction. Researchers at LUMC are trying to steer the immune system. The dossier on Immunity, Infection…
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Innovative approach to antibiotic resistance
Resistance to antibiotics is a major problem in health care. Thanks to a grant from the Elise Mathilde Fund and the LUF, pharmacologist dr. Coen van Hasselt can look for new dosing schedules to reduce the development of antibiotic resistance.
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New substances inhibit inflammation in the brain
Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…
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UMCs join forces to increase pandemic preparedness
Four university medical centres, including the LUMC, are joining forces to increase pandemic preparedness in the Netherlands.
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NWO awards curiosity-driven research Ariane Briegel with grant
Professor of Ultrastructural Biology Ariane Briegel has received a grant in the NWO Open Competition Domain Science in the XS category. This grant emphatically encourages curiosity-driven and bold research with a maximum of 50,000 euros.
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Microbial protection of food crops and human health
We investigate bacteria and fungi to understand their malicious or beneficial impact on food crops and their pathogenic or antibiotic role in human health.
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.
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COVID-19 Library update
Dear library friends,
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Leiden students develop highly contagious card game
Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…
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Combatting antibiotic resistance in a clever way
When you become very good at one thing, that sometimes comes at the expense of something else. Such trade-offs also apply to bacteria. When becoming more resistant to one antibiotic, bacteria can sometimes become more sensitive to another. Linda Aulin, PhD candidate in the pharmacology group of Coen…
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Improving nature’s antibiotic
'What nature made isn’t necessarily an optimized medicine to use in the human body,’ says Professor of Biological Chemistry Nathaniel Martin. That’s why a group of Leiden researchers is making a chemistry-based improved version of the frequently used antibiotic vancomycin. They received an NWO NACTAR…
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Eduard Fosch-Villaronga & Louk van Doorn win the DT4REGIONS Ideathon on AI Potential for Preventive Healthcare
eLaw - Center of Law and Digital technologies from Leiden Law School, and the Vascular Surgery Department at Leiden University Medical Centre in the Netherlands, join forces to explore the use of AI for diabetes and secondary prevention of diabetic foot problems and won a prize for it.
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William Michael Schmidli: ‘Regardless of the vote count, Trump will not leave the White House easily’
With only a month until the 2020 United States elections, William Michael Schmidli, University Lecturer of American history, reflects on the latest developments. President Trump’s COVID-19 diagnosis seems apt for the nation too, he argues.
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Engineering innate immunity for therapy
Immune system defends our body against pathogens and cancerous cells, but excessive immunity can in turn lead to tissue damages and diseases. For example, scratching the surface of the eye ignites an immune response that aims at preventing infection but can also lead to edema, angiogenesis and eventually…
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Annemarie Meijer appointed full Professor of Immunobiology
Annemarie Meijer is appointed full Professor of Immunobiology. Meijer’s research focuses on immunobiology and infectious disease. She uses the zebrafish as a model for understanding mechanisms of host immune defense against intracellular bacterial pathogens.
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Leiden cholera epidemics mapped out, literally
Three cholera epidemics struck 19th-century Leiden. Today’s corona epidemic prompted Martijn Storms, curator of maps and atlases at the Leiden University Libraries, to scour the library for maps about these past epidemics.
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Cognitive Emotion Regulation Questionnaire (CERQ)
CERQ is a questionnaire measuring cognitive coping strategies developed by Dr. Nadia Garnefski and Dr. Vivian Kraaij.
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Improving the treatment of pathogenic fungi. ‘The process is working, but not that well…’
Fungi germinating in the lungs of patients. Doesn’t sound too nice, does it? Luckily, humans can deal with this normally, and we are able to clear the infection before anything comes to harm. However, in people with health issues, Aspergillosis can cause a lot of damage, especially if the fungus becomes…
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NWO grants two IBL-proposals by interdisciplinary research consortia
Recently, NWO has decided to grant two interdisciplinary research proposals for national and international consortia submitted by researchers from the Institute of Biology Leiden. One of the proposals is led by Prof. dr. Ariane Briegel, the other one by dr. Remko Offringa.
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Researchers tackle antibiotic-resistant bacteria
When a bacterium becomes more resistant to one antibiotic, it sometimes becomes more sensitive to another. To better understand this interaction, researchers from the Leiden Institute of Biology (IBL) and the Leiden Academic Center for Drug Research (LACDR) under supervision of Daniel Rozen and Coen…
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Clever variant of antibiotic bypasses resistance in bacteria
Biological chemist Nathaniel Martin is going to test an alternative antibiotic that can combat common resistant bacteria such as MRSA. For this purpose, he will receive 350,000 euros from the NWO's NACTAR programme. ‘We want to know how safe and effective our antibiotic is in a realistic situation.’
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The evolutionary added value of sex
Asexual procreation in female wasps leads to an accumulation of genetic mutations, and the shrivelling of their sex organ. Leiden biologist Ken Kraaijeveld published this discovery in Evolution. His research is one of the first experimental studies into the consequences of asexual procreation.
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Improving therapeutic vaccines
Chemist Sander van Kasteren aims to accurately map how our immune system responds to vaccines, particularly those aimed at curing diseases like cancer and chronic viral infections. The goal is to use this knowledge to improve vaccine design. An ERC Consolidation Grant will provide him with the funding…
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New insight into immune cell behaviour offers opportunities for cancer treatment
An international group of scientists has discovered that certain cells of our immune system – the so-called T cells – communicate with each other and work together as a team. To fight an infection they stimulate each other’s growth, but at the same time, they inhibit each other when there is a surplus…
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Different medication dosage for morbidly obese patients
PhD research recently completed by pharmacologist Margreke Brill shows that morbidly obese patients should be given a different dosage of the drugs Cefazolin and Midazolam. This could also apply to other drugs such as anti-cancer drugs as well as antibiotics and Margreke Brill is advocating a change…
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How cholera bacteria make people so sick
The enormous adaptability of the cholera bacterium explains why it is able to claim so many victims. Professor Ariane Briegel from the Leiden Institute of Biology has now discovered that this adaptability is due to rapid sensory changes in the bacterium. Publication in PNAS.
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Nathaniel Martin: why won’t antibiotics cure us anymore?
Current means of fighting bacteria are no longer as good as they used to be because of antibiotic resistance. These days, people are dying from bacterial infections that could have been cured fifty years ago.
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How do you prevent viral outbreaks? By protecting animal health
Many dangerous diseases such as COVID-19, Ebola and Q fever have jumped from animals to humans. But it is not only because of these diseases that we should include animals in our health policy, but also because of their right to health, writes PhD candidate Joachim Nieuwland. PhD defence on 13 May.
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When will there be a coronavirus vaccine?
The genetic code of the new coronavirus has been found: it is closely related to the SARS virus from 2003. Professor of Molecular Virology, Eric Snijder, has been researching coronaviruses for years. We asked him a few questions about the outbreak. ‘It’s still unclear whether this new virus is more…
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Zebrafish models for disease and environmental stress
We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.
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Cyber security
To make digital communication more secure, we need to tighten up the legal frameworks and identify the biggest cyber threats.
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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Reconciling conflicting interests
If a society is to be secure, sustainable and resilient, conflicting interests must be reconciled. Researchers at Leiden University study the behaviour of individuals, groups and states in relation to this issue, and use their knowledge to promote equality within and between communities.
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Optimal Teaching
The better teaching is for pupils and students, the more solid the basis will be that we give them for their future careers. This type of teaching requires strong instructors and insight into the best ways in which pupils can be supported, and research at Leiden University is making a contribution in…
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International Tax Law
Loopholes in international tax legislation contribute to the misuse of tax rules by multinationals. Leiden University legal experts investigate how the complex national and international tax rules can be made more consistent in order to create a better tax system.
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Taking care of your health
Health is a wonderful gift, both for humans and for society. If we are able to prevent both physical and mental illnesses, we can spare a lot of suffering and fight rising health costs. Social scientists and physicians in Leiden are working closely together to conduct research on the human mental, behavioural…
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Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…
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Awards and Grants 2022
An overview of awards and prizes granted to our staff and students in 2022, as well as special appointments at Leiden University and other institutions.
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Making and creating with ages-old knowledge
The ability to create objects and structures with our hands has been essential to human development. This ability is something modern society is at risk of losing. Leiden archaeologists gather knowledge about ancient processes of ‘making and creating’ over the centuries, knowledge that helps our current…
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The skeleton as a source of information
Bones contain information about people’s lives such as where they came from, their age at death and which diseases they suffered from. Researchers can deduce a lot from them about a person’s life and about human evolution. This generates leads that could help solve present-day problems, such as how…
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From Data to insight
Social science research helps us understand human behaviour and social structures. These are determined by various factors, which makes the research complex and increases the likelihood of drawing the wrong conclusions. The choice of research method and analysis is therefore extremely important. It…
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Research lines
Physics and Engineering Approaches to Biomedicine and Pharmacology
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…