In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Leiden has a strong tradition in theoretical physics, thoroughly linked with experimental disciplines.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

The main focus of our research programme is on adolescence, a key transitional period in human development. The programme puts emphasis on combined experimental behavioural and neural analysis of normative transitions and deviations in adolescent development.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Source: PLoS ONE, Volume 10, Issue 3 (2015)

What role play stress and fear in forming of nocebo hyperalgesia?

In this study Lilie Roosman describes the effects of prominence and boundary marking on the temporal and melodic structures of two regional languages of Indonesia, viz. Toba Batak, a stress language, and her native language Betawi Malay, a non-stress language.

Social anxiety and factors determining school success in children. Brain development in relation to cognitive, social and emotional development in adolescence.

Effects of age and social anxiety

Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.

PhD defence

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

The Physics and Quantum Matter and Optics specialisation is one of the two programmes Leiden offers in experimental physics. The programme can be tailored to individual needs and interests.

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…

Sense Jan van der Molen is vanaf 1 maart de nieuwe wetenschappelijk directeur van het Leiden Instituut voor Onderzoek in de Natuurkunde.

Without electronics carrying out computational tasks our daily lives would look very different. Devices such as elevators, vending machines, turnstiles, washing machines and even traffic lights use a simple form of electronic computing to switch from state to state. But, what if power supply is not…

Tjerk Oosterkamp of the Leiden Institute of Physics managed to do the first-ever measurement of gravity on a tiny particle - just 0.43 milligrams - where the quantum regime starts. He explains in Physics World why this is so challenging.

On the 6th of July, wood specialists, members of the canoe club Natsec, a professional boat builder, volunteers of the Vlaardingen Broekpolder and students and staff of the Faculty of Archaeology of the Leiden University gathered on the waterfront in Vlaardingen. Two reconstructions of prehistoric canoes…

Although it is often assumed that the stereochemistry in Ugi multicomponent reactions is determined in the final Mumm rearrangement step, experimental and computational evidence that Ugi reactions on hydroxylated pyrrolines proceed under kinetic control is reported.

Microbial Sciences' contribution to the Evolution & Biodiversity research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.

The drug discovery pipeline is used to describe the stages in drug discovery. The earliest stage concerns with the identification of potential targets and molecules ('hits') that can modulate their function, while more advanced stages are about developing these hits into viable experimental drugs and…

Mechanical interactions between cells and their environment play an important role in many biological processes.

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…

Considering Mesoamerican Precolonial books as material objects

Birds sing to be heard, but how do they cope with increasing noise levels? Which species persist in cities and why? And do they thrive or suffer in the urban soundscape?

Dive into the heart of archaeological science: explore the flora and fauna of bygone ages, study human bones and teeth, analyse the cultural biographies of material objects, or become an expert in the use of digital data in archaeological research.

The Leiden Institute of Physics (LION) offers bachelor and master level education in physics at Leiden University.

How can misleading graphs be effectively corrected, specifically for people with low graph literacy?

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Our group explores the larger domain of quantum measurement. In particular we investigate two themes that are closely connected: The detection of specially prepared quantum states of light and understanding and characterizing quantum photon detectors.

How does stress affect different components of behavioral impulsivity and aggression in patients with Borderline Personality Disorder compared to clinical controls (patients with Attention Deficit Hyperactivity Disorder) and healthy controls?

Practical information about the physics summer school of Leiden University: the frontiers of modern physics. This page contains information about the cost and price of the summer school, the available scholarships, location, housing and the programme. This summer school is a part of the Leiden Insitute…

In the one-year Linguistics specialisation programme you will be able to focus on a specific thematic or disciplinary route, reflecting the linguistics expertise present at Leiden University.

The research master's specialisation Cognitive Neuroscience consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.

The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

The section Developmental and Educational Psychology consists of more than 45 people, who are mainly involved in education and research.

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Political scientist Luzia Helfer (Leiden University) empirically tested claims about media-politics relatiopns using unique data from experimental studies with elected politicians and political journalists in Switzerland and the Netherlands.

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Promotor: A.P.IJzerman Co-promotor: A. Bender

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

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Promotor: M. Ubbink, Co-promotor: G. Siegal