How do macrophages and neutrophils contribute to metastatic onset?

What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.

Impressions by Dr. Lilian Ruhe

Governments in parliamentary democracies have limited time in office to fulfill their policy agendas. So, how do they optimise the timing of legislative bills to assure their passage and avoid lengthy parliamentary scrutiny? This question is especially puzzling under coalition governments, in which…

Leiden chemists have developed a new technique with which they can determine the role of kinases – a group of proteins – in a living cell. This technique makes it easier to find new drug targets for diseases such as cancer and rheumatoid arthritis. The team published the findings in the journal Nature…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Christmas is coming, which means that 'Our Talents and Discoveries 2016' has been distributed. This also means that it is time to vote for the 'Discoverer of the year 2016'. Each of the eight institutes nominated one researcher that excelled in the past year. Who is your favourite?

This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB

Power and Legitimacy in Kingship, Religion, and the Arts Volume 87 in the series Religion and Society

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Psychedelic drugs like magic mushrooms and LSD are embraced by some and seen as lethal by others. Cognitive psychologist Michiel van Elk delved into the world of psychedelic drugs and wrote a surprisingly sober book about them. ‘Without first-hand experience my story wouldn’t be complete.’

Impressions by Oene de Haan - PhD candidate at Utrecht University

As a prelude to the Night of Discoveries, an Afternoon of Discoveries will be held in Leiden on 21 September for children from the age of eight. Researchers will tell exciting tales and the children will get to do experiments.

The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.

The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

In health care, artificial intelligence is quite normal: it is used, for example, as an aid in making diagnoses. However, artificial intelligence is not yet used as much in drug development. A new prestigious partnership is therefore going to investigate how artificial intelligence can contribute to…

Minister Grapperhaus wants to use intelligence services in the investigation of drug crime. There are many doubts about this wish in the intelligence world. Paul Abels, Professor by Special Appointment Governance of Intelligence and Security Services at the Institute of Security and Global Affairs (ISGA),…

We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine and Pharmacology, and the Metabolomics and Analytics Centre.

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Drug Discovery and Safety consists of 120 European Credit Transfer System (EC) points. NOTE: This specialisation will be integrated into the new specialisation ‘’Research in Bio-Pharmaceutical Sciences’’ as of September 2025.

How can we understand the encounter between communities active in sustainability initiatives and governmental agents at the multiple institutional layers in the Netherlands?

One of the highlights during the fieldwork in Schoningen lead by Prof. dr. Thijs van Kolfschoten in 2013 was the opening of the museum and research center paläon on June 24. To the realisation of the museum, the Faculty of Archaeology made ​​a significant contribution. Many of the results of the research…

Over 4,000 visitors came to the seventh edition of the Night of Discoveries, a festival of knowledge and culture, on Saturday 21 September. On this the last summer evening of the year, the festival-goers were treated to over 170 acts on the theme of light and dark, making it a vibrant, busy, educational…

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.

Does a drug enter into the human brain once administered in the body?

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells. This is what an international group of researchers from Leiden University and Erasmus MC, among others,…

Chronic pain, nausea or vomiting due to chemotherapy. If you suffer from such ailments, medicinal cannabis can be a godsend. Though a downside is that it can make patients high. Therefore, Leiden researchers from the Oncode Institute are investigating alternatives that do not make you high. In Nature…

Finding structure in disordered proteins and developing drugs for undruggable diseases: it might sound like mission impossible, but pharmacologist Alireza Mashaghi and his team are right on top of it. Their project was awarded by NWO through the Open Competition Domain Science -XS, a competition that…

Promotor: A.P. IJzerman

Promotor: M. Ubbink, Co-promotor: G. Siegal

Some of the most significant and surprising astronomical breakthroughs that have shaped science, technology and culture over the last century are showcased in the Above and Beyond open-source exhibition. This exhibition was commissioned within the framework of the International Astronomical Union's…

Professor Annemarie Meijer and several students explained to more than 8000 visitors the zebrafish as a model for research during the National Weekend of Science (3-4 Oct) at Science Center NEMO in Amsterdam.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

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