2,521 search results for “thijs werkt e2 80 99s discovery” in the Public website
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Leiden archaeologists mentioned in Top 13 Discoveries in Human Evolution during 2023
In a recent article published on PLOS, Drs. Briana Pobiner and Ryan McRae of the Smithsonian Institution National Museum of Natural History discuss the top 13 discoveries in human evolution in 2023.
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Artificial intelligence as the co-pilot for drug discovery
There are more molecules that could conceivably be candidate drugs than there are stars in the universe. How can we ever efficiently identify those molecules? Professor of AI and Medicinal Chemistry, Gerard van Westen: ‘I’m going to use artificial intelligence as the co-pilot to make an automated search.’…
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Proteochemometrics
Research question
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Anthe Janssen
Science
a.p.a.janssen@lic.leidenuniv.nl | +31 71 527 4362
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Discovery of a unique silver bowl from the Early Middle Ages
On an excavation site in Oegstgeest Leiden University archaeologists discovered a very rare silver bowl from the first half of the seventh century. The bowl is decorated with gold-plated representations of animals and plants and inlaid with semi-precious stones. The discovery suggests the existence…
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Rob van Wijk discusses the role of zebrafish in drug discovery
Rob van Wijk gave an interview on the role of zebrafish in drug discovery and development, published in FIGON’s journal Medicines as a preview of LACDR’s representation at the PhD competition during the Dutch Medicines Days (DMD). The entire interview can be read below.
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Night of Discoveries: 3D-printed paintings and the effects of psychedelics
Come to the Night of Discoveries art and science festival on 16 September. Various researchers from the university are speaking at the festival.
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De bescherming van immateriële contractuele belangen in het schadevergoedingsrecht
On 30 June 2021, Thijs Beumers defended his thesis 'De bescherming van immateriële contractuele belangen in het schadevergoedingsrecht'. The doctoral research was supervised by Prof. A.G. Castermans and Prof. W.H. van Boom.
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Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Flurry of new discoveries as incredible new image revealing 4.4 million galaxies is made public
Over a seven year period an international team of scientists has mapped more than a quarter of the northern sky using the Low Frequency Array (LOFAR), a pan-European radio telescope. From Leiden, Astronomer Timothy Shimwell and Huub Röttgering, among others, are involved. It reveals an astonishingly…
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Can we live longer? Leiden physicist makes discovery in protective layer in genes
With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery…
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Wil Roebroeks interviewed about new discoveries Borneo: "This killed Eurocentric views on early rock art"
In a remote cave on the Indonesian island of Borneo, a series of rock art paintings have been discovered. The oldest painting might be the oldest-known example of figurative cave art. Wil Roebroeks, not himself involved in this project, reflects on the findings in several media.
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Sebastian Pomplun
Science
s.j.pomplun@lacdr.leidenuniv.nl | +31 71 527 4651
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AiChemist project
The AiChemist project (https://aichemist.eu) coordinated by Helmholtz Munich is an Innovative Doctoral Training Network funded through the Marie Skłodowska-Curie Actions (MSCA-DN) within the EU Horizon Research Framework, to the sum of €3 million. It brings together leading experts in AI, chemoinformatics…
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Research
Within the Chinese medicine, more than 80% of the constituents of the preparations are derived from plants. Like any other organism, plants are constantly interacting with their changing and often harsh environment during the various phases of their life cycle.
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From lab discovery to a new drug: the Venture Challenge makes it possible
A breakthrough from the PhD research of medical chemist Elmer Maurits may help patients with autoimmune diseases and blood cancer in the future. But bringing a discovery from the lab to the clinic is not so easily done. Thanks to NWO's Venture Challenge, Maurits and his team will receive ten weeks of…
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Luuk Esser in the media on discovery of 39 bodies in England
The British police discovered 39 bodies in the back of a lorry earlier this month. The refrigeration unit in which the bodies were found had entered the United Kingdom via Belgium.
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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From discovery to business: 'In the lab, we often don't realise that we are working to help an immense number of patients'
'It gave our team a big boost to hear that our work was valuable,' says medical chemist Elmer Maurits about the moment they won the Venture Challenge. With their company Iprotics, they want to develop a drug that can better treat patients with autoimmune diseases and blood cancers. 25,000 euros of prize…
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Discovery Leiden nominated for KIJK: Best Tech-idea of 2021
Using artificial intelligence to find new antibiotics. With that, researchers from Leiden University are nominated by magazine KIJK for the Best Tech-idea of 2021. From September 14 onwards people can vote to crown one of the nominees as the winner.
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Postponement of the Congress on the Social Benefits of Higher Education to the autumn
The organising committee of the congress 'Social Benefits of Higher Education' has decided to postpone the congress.
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Arteriosclerosis and drug discovery: two young researchers win Krijn Rietveld Award for innovative research
One discovered that arteriosclerosis resembles an autoimmune disease, while the other developed a system to aid in the search for new medications. For these achievements, Marie Depuydt and Jurren de Groot were awarded the Krijn Rietveld Memorial Innovation Award on the evening of Tuesday 4 June.
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Kennemerland in metaalvondsten
Duizenden metaalvondsten die door detectorzoeker wijlen Herman Zomerdijk zijn gedaan in de regio Kennemerland schetsen een uniek beeld van Noord-Holland door de eeuwen heen. Hij zocht en verzamelde decennialang historische metalen objecten in Noord-Holland en bouwde zo een unieke metaalcollectie op.
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Medieval and Early Modern Studies (c. 600-1800)
This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.
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The Social Ties that Bind: Unraveling the Role of Trust in International Intelligence Cooperation
Together with Pepijn Tuinier and Thijs Brocades Zaalberg, Sebastiaan Rietjens researched the role of trust in an international intelligence cooperation.
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Predicted microplastic uptake through trophic transfer by the short-beaked common dolphin and common bottlenose dolphin
In this study, Tessa Dool and Thijs Bosker estimate the microplastic uptake of two odontocetes in the Mediterranean Sea and the Norteast Atlantic.
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Teaching Prize
Each year, the Leiden University Student Platform (LUS) presents the Leiden Education Prize.
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Customary Authorities and Environmental Governance in Africa: A Systematic Review
This systematic review of 68 English-language articles explores the roles of customary authorities in environmental governance in sub-Saharan Africa
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
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Determining global distribution of microplastics by using citizen science
The objective of this study is to better understand the distribution of microplastics in the environment. More specifically, we will quantify the abundance and distribution of microplastics on beaches.
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First discovery of methanol in a warm planet-forming disk
An international team of researchers led by Alice Booth (Leiden University, the Netherlands) have discovered methanol in the warm part of a planet-forming disk. The methanol cannot have been produced there and must have originated in the cold gas clouds from which the star and the disk formed. Thus,…
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Contact
The Leiden Risk and Regulation Lab contact details
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Robust rules for prediction and description.
In this work, we attempt to answer the question:
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Opening Academic Year 2019-2020
The opening of the Academic Year 2019-2020 took place on Monday 2 September 2019 in Pieterskerk church.
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The Leiden University Old English ColloQuest
The Leiden University Old English ColloQuest is a digital, dynamic edition of an Old English text that adapts to each different learner to offer an appropriate level of challenge. The nature and number of glosses (translation aids) on the text adjust for each individual user based on the user’s answers…
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Self Defense: Mimicking natural deterrent strategies in plants using adhesive spheres and volatiles
How can we make agricultural production systems more sustainable as the worldwide demand for healthy, safe food continues to grow? How can we develop healthy new food crops that have higher yields while requiring fewer harmful chemicals?
- Medieval Fragmentology and the Fragmented Old English Glossed N-Psalter
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Towards a sociology of recurrent events: Constellations of cultural change around Eurovision in 18 countries (1981–2021)
In this article, the authors explore the concept of recurrent events, particularly focusing on the Eurovision Song Contest.
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Laura Heitman
Science
l.h.heitman@lacdr.leidenuniv.nl | +31 71 527 4558
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Weblogs and podcasts
Academic staff and students blog about their research and teaching.
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Adviseur subsidieaanvragen 1
Science, Leiden Institute of Physics (LION)