The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Both the Dutch government and the European Commission dedicate an increasing share of public funding for research and innovation to mission-oriented programs, aiming to facilitate sustainability transitions. These programs typically involve support fora range of different research activities, from the…

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Our AI researchers work closely with other institutions such as Delft University of Technology and Erasmus University.

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

The members of LUXs develop and validate new methods and algorithms for analysing data, and apply these in a wide range of problems. Their research ranges from multidisciplinary applications to proving mathematical theorems.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Essays in Honour of Olivier P. Nieuwenhuyse

Source: Eur J Med Chem (2015)

On Thursday 11 May 2017, Qiang Yu defended his doctoral thesis ‘Market Power and Competition Law in the Software Industry’. The supervisors of the research are Professor T.R. Ottervanger and Professor S.C.G. Van den Bogaert. A brief summary of his thesis is provided below.

Ömer Gürlesin defended his thesis on 28 November 2018

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

What plants grow along ditches in the Leiden region? What does this say about vegetation quality? Could it be better? Naturalis and Leiden University's Center for Environmental Sciences are looking for your help to answer these questions.

Here we share findings into the effectiveness of the Designing Your Life education at Leiden University. Our study indicates that DYL education has a positive effect on students’ confidence and competencies.

Kernvisie BRUIST taskforce juridisch bacheloronderwijs

To find out more about the conditions and criteria for participating, please read here.

The two-year programme consists of 120 European Credit Transfer System points (EC) and includes core courses (30 EC), two Industrial Ecology Projects (20 EC), specialization courses (35 EC) and the Thesis Research Project (35 EC).

The renovation of the Herta Mohr building (formerly known as Cluster Zuid) is completed. It is the third project in the redevelopment of the Humanities Campus. With the renewal of these buildings, the university ensures a sustainable campus with modern facilities. The university wants to create an attractive…

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

How can the Safe and Sustainable by Design (SSbD) framework developed in the SSbD4CheM project facilitate the creation of safer and more sustainable chemicals and materials across various industries?

How can computers help design optimal buildings? PhD student Koen van der Blom makes algorithms that take into account all kinds of different architectural requirements, in order to reach the best compromise. And that is quite difficult: 'Algorithms do not automatically understand that a building that…

Spatial analysis on the basis of material culture has always been one of the major topics in archaeological research. Designating Place analyses the urban space of Roman Ostia and Pompeii in different ways, namely via geophysical analysis, spatial analysis, iconographic analysis and epigraphic analy…

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

An international team of researchers, including Federico Calle-Vallejo of Leiden University’s Institute of Chemistry, have taken the atomic-scale design of catalysts to the next level. Their research contributes to the quest for a method to generate or store energy more efficiently. The report is published…

Arco Timmermans, Professor by special appointment Public Affairs at Leiden University, brought sience to practice by designing an “ideal” academic education programme on public affairs, to be embedded and taught at the graduate level.

Science, Leiden Institute of Advanced Computer Science (LIACS)

The central issue of this research concerns how students can best be supported in their study choice, study career and future orientation with a view to flexible entry and transitions and perspective in education and work.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.

Promotor: J.N. Kok, Co-promotor: F.J. Verbeek

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

April 2021 saw the publication of the book ‘Cross-Border Protocols in Insolvencies of Multinational Enterprise Groups’. This book was published by Edward Elgar Publishing. It is written by Ilya Kokorin and Bob Wessels. The book serves as a comprehensive introduction to insolvency protocols and focuses…

A hot topic in educational sciences is whether and how reading medium (paper vs. screen) affects reading comprehension. Especially in the media – but also in schools – their appears to be a preference for texts presented on paper: Paper texts are thought to induce a more intensive reading strategy,…

2 joint initiatives began in 2019 which attempt to connect the various efforts around active learning at Leiden University: the active learning network, and the Saltswat project.

The Paramagnetic NMR Facility Leiden has been established to provide support to researchers who want to apply paramagnetic NMR spectroscopy to biomolecules. Support is offered in the design and synthesis of paramagnetic probes, either for general application (such as lanthanide tags and spin labels)…

The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…

This research explores the question of what contemporary mapmaking practices can reveal about the ever-evolving field of graphic design.

Drug development is a complex process in which many parties work together. Every day, the researchers at LACDR devote their energies to developing drugs that are new, better, more efficient and easier to produce. And thus to the millions of patients who know all too well why this research in Leiden…

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

Research into the development of privacy-friendly care games for children.

Supervisor: Gerard van Westen

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…