389 search results for “microscopy” in the Public website
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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The electrode-electrolyte interface in CO2 reduction and H2 evolution: a multiscale approach
Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.
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Frontiers of Modern Physics
This is the physics summer school of Leiden University. It is part of the Leiden Institute of Physics (LION). The summer school is intended for Bachelor (BSc) students in physics. It covers topics from quantum matter and optics, to biological & soft matter physics and cosmology and theoretical physics.…
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Evolution of bacterial movement revealed
An international team with researchers from Leiden revealed how a bacterium repurposed an internal system to control its movements. Movement control is very important in host invasion, which can lead to disease. Publication on 27 April in Nature Communications.
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Bas ter Braak
Science
s.j.ter.braak@lacdr.leidenuniv.nl | +31 71 527 2727
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Marcel Schaaf
Science
m.j.m.schaaf@biology.leidenuniv.nl | +31 71 527 4975
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Steffen Brünle
Science
s.bruenle@lic.leidenuniv.nl | +31 71 527 4544
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Ariane Briegel
Science
a.briegel@biology.leidenuniv.nl | 071 5272727
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Joan van der Waals colloquium
The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.
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Renewable Energy
The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Drug Discovery & Safety
In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
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Milan Allan Lab - Understanding Quantum Matter
We are a dynamic research group at the Leiden Institute of Physics. Our aim is to explore and understand quantum materials, including strange metals, high-temperature superconductors, and quantum critical electron matter.
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Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers
What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?
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Setup: Low Temperatures
A lot of our research is performed at temperatures close to absolute zero, among other reasons because this increases the sensitivity of the measurements.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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Cryo-EM of cholera infection
The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?
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Stable single molecules for quantum optics and all-optical switches
Promotor: Prof.dr. M.A.G.J. Orrit
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Student projects
To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
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Evolution and development of flowers, fruits and inflorescences of Phalaenopsis and other orchid species
The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.
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Scalable organic solvent free supercritical fluid spray drying process for producing dry protein formulations
In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.
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Cum laude on understanding catalysts under extreme conditions
Physical chemist Rik Mom developed a revolutionary way to investigate catalysts in action in detail. For this work he received the distinction cum laude during his PhD defence on 29 June.
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Working at the Faculty of Science
Working for a top faculty? Discover the vacancies at the Faculty of Science and apply immediately.
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Research
An overview of the research at the Cancer Dug Target Discovery group.
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Laboratory for Artefact Studies
Commercial enterprises who want to make use of the expertise and facilities are referred to LAB , the commercial unit responsible for specialized laboratory work.
- Jan van Ruitenbeek Lab - Atomic and Molecular Conductors
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Solid State NMR and modelling of photoinduced energy and electron transfer
Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…
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Vibration Isolation
To be able to measure small forces or small deviations from Boltzmann, the external vibrations at the resonance frequency must be very low. To achieve this, we have developed a very soft vibration isolation system and combine it with several other measures to reduce vibrations in our dilution refrigerators.…
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Self-assembly properties and applications of metal-binding peptides and proteins
It is estimated that approximately 30% of all proteins require a metal to function. Investigating the relationship between metal-binding and peptide/protein folding allows us to uncover fundamental rules for creating metallo-peptides and proteins, which in turn leads to the creation of new structures,…
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Ariane Briegel: 'AI literally opens new worlds for the life sciences'
Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’
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Personal ornaments: changing identities in the Dutch Neolithic and Bronze Age
Numerous beads and pendants of amber, jet and bone have been found in Dutch Neolithic and Bronze Age context, both in settlements and in graves. Because ornaments are personal items, they are closely linked with people’s identity.
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Cell Observatory: visualising structures of life
From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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COVID-19 vaccine
Leiden researchers are helping develop safe COVID-19 vaccines.
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Bachelor Projects
Bachelor projects are available in
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OMERO
From the microscope to publication, OMERO handles all your images in a secure central repository. You can view, organize, analyze and share your data from anywhere you have internet access. Work with your images from a desktop app (Windows, Mac or Linux), from the web or from 3rd party software. Over…
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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Imaging & Intervention (MSc)
This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.
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Life Sciences Café visits NeCEN
On 21 March The Netherlands Centre for Electron Nanoscopy (NeCEN) hosted the Life Sciences Café. Around 60 people from neighbour companies from the Leiden BioScience Park visited the facility for cryo-electron microscopy to get a glimpse behind the scenes. Head of NeCEN Ludo Renault believes it was…
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Physicist Sense Jan van der Molen plays ‘Dutch shuffleboard’ with electrons
Physicist Sense Jan van der Molen researches materials that do not exist in nature. ‘It’s fascinating to see how the properties of a material change if we manage to make it super thin.’ He will give his inaugural lecture on 21 October.
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New IBL-professor in Ultrastructural Biology: Ariane Briegel
Ariane Briegel has been appointed Professor in the fìeld of Ultrastructural Biology within the Faculty of Science at the Institute of Biology from the 1st of December 2015. Her expertise is in using electron cryotomography to study how microbes sense and respond to their environment.
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Erik Danen
Science
e.danen@lacdr.leidenuniv.nl | +31 71 527 4486
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Bob van de Water
Science
water_b@lacdr.leidenuniv.nl | +31 71 527 6223
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PhD Position(s): Assessing the molecular structure of electrochemical interfaces
Science
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Ten million euros for unlocking novel technologies in structural biology
The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…