Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Lecture, Lecture part of a series

We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.

There are effective treatments for people with autism, says Wouter Staal, professor of Autism Spectrum Disorders, in his inaugural lecture on 4 May. However, it is not yet clear which treatment is most effective for which individual.

PhD defence

At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells. This is what an international group of researchers from Leiden University and Erasmus MC, among others,…

PhD defence

Members of our research team give different types of presentations and lectures.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

SEAtrans: an interdisciplinary research project that aims at studying the dynamics and processes of transitions in society-nature interactions in Southeast Asian societies.

The programme of the 3rd International Workshop on Klinefelter Syndrome, Trisomy X, and XYY. International Workshop theme: 'A life-course perspective'

The Basics and Applications to Plant Sciences will be held physical. See below for more information.

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Urbanization brings benefits like housing and jobs but also challenges like biodiversity loss. CML's Urban research program uses science to create sustainable cities, focusing on the built environment (circular economy, urban mining) and enhancing urban nature for biodiversity and human benefits.

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

A scenario building web-tool and knowledge package to enable multi-level decision making for the transition to the Circular Economy

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

School of pharmaceutical sciences, University of Geneva - Switzerland

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

Key publications of the Analytical BioSciences and Metabolomics group

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.

The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.