There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Keynote Lecture

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.

Interaction between Legal Systems acknowledges that law-making and law enforcement are increasingly taking place on various levels: in a global context, in EU context, on a national level and in a private law framework. These levels influence each other, sometimes directly, on the basis of a hierarchical…

HomininSpace is an agent based modelling and simulation system in which fluctuating carrying capacity is the key attractor for hominin dispersal. A parameterized and spatially explicit reconstructed palaeo-environment models available energy in the form of secondary biomass using reconstructed climate…

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

How do balanced lethal systems originate and persist in nature?

The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

The main question of this research project concerns the extent to which light verbs in West Germanic languages participate in processes of language change.

Duality, stochastic processes

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…

Big data promises to transform public decision-making for the better by making it more responsive to actual needs and policy effects. However, much recent work on big data in public decision-making assumes a rational view of decision-making, which has been much criticized in the public administration…

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Science, Leiden Institute of Advanced Computer Science (LIACS)

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

This project investigates the transposition of natural historical material, knowledge and vision, between different media (collection, scientific drawing, academic texts, the visual arts and/or literature) – a transmission that happens in the borderline between the traditional, emblematic worldview…

Research into research improves the academic system. CWTS studies and evaluates the academic system in various ways. One way is to provide information on the productivity and impact of academics by documenting how many publications they or their universities produce and how often these publications…

Lecture, CHiLL series

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.

An important hormone excreting gland in the human body is the pituitary

A network combining 9 academic research groups and 4 collaborating industrial companies will train the next generation of PhD students and post-doctoral researchers, in developing and applying novel experimental and theoretical methods in the NMR spectroscopy of systems containing paramagnetic metals.…

PhD defence

In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Dishoeck

Uncovering task solving processes in dynamic testing

Across Europe, the need for a more dynamic governance and a better societal integration of research and innovation is increasingly appreciated. Internal drivers of change (such as the digitalization of science) and political will to better align with societal needs and concerns are bringing about aspirational…

Mathematics forms the basis of many innovations in technology, the service industry and science, such as data analysis and coding, artificial intelligence, weather or climate change modelling or understanding molecular processes. The researchers from the Mathematical Institute (MI) are constantly developing…