4,015 search results for “discovery of the year” in the Public website
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ZF-CANCER - Developing high-throughput bioassays for human cancers in zebrafish
How can zebrafish research help to understand and fight human cancer?
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Nobel Prize for physics: 'Clear solutions are the best discoveries'
What does Leiden physicist Wolfgang Löffler think about the award of the Nobel Prize for physics to Arthur Ashkin, Gérard Mourou and Donna Strickland?
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Can we live longer? Leiden physicist makes discovery in protective layer in genes
With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery…
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Research
The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine and Pharmacology, and the Metabolomics and Analytics Centre.
- Leiden Science in 2023
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Archaeology of the Lower Maroni River
The application of compliance archaeology techniques such as mechanical large scale excavations where large quantities of data are gathered in relatively little time (and relatively inexpensively) and a firm post-excavation research phase yielded a whole new body of archaeological evidence.
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Kristof Gombeer
Faculteit Rechtsgeleerdheid
k.c.n.gombeer@law.leidenuniv.nl | +31 71 527 2727
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Drug discovery 3.0: more effective and humane
Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.
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Grants & Awards
Grants awarded to molecular physiology research
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Island Networks
The focus of this programme is the inter-community social relationships and transformations of island networks in the Lesser Antilles across the historical divide.
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Three discoveries for cleaner and cheaper fuel
How can rare and expensive materials be used more efficiently to produce cleaner and cheaper fuel? Under the guidance of Marc Koper, Professor of Catalysis and Surface Chemistry, international teams of scientists have published 3 articles in Nature Communications.
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Leiden discovery evaluated by world-leading breeding companies
Various companies in the plant biotech industry will test a recent Leiden discovery in their crops. The ‘Pol Theta’ technology is developed in Leiden and makes it possible to reduce undesired side effects during genome engineering of plants.
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Flurry of new discoveries as incredible new image revealing 4.4 million galaxies is made public
Over a seven year period an international team of scientists has mapped more than a quarter of the northern sky using the Low Frequency Array (LOFAR), a pan-European radio telescope. From Leiden, Astronomer Timothy Shimwell and Huub Röttgering, among others, are involved. It reveals an astonishingly…
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Presentations eLaw at 'Brave New World' and 'Night of Discoveries'
eLaw - Center for Law and Digital Technologies, is well represented at a number of activities in Leiden this week concerning Technology and Society!
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De Witte et al publish in Nature Drug Discovery Reviews
Nature Reviews Drug Discovery volume 18, pages 82–84 (2019). The implications of target saturation for the use of drug–target residence time Wilbert de Witte, Meindert Danhof, Piet van der Graaf, and Elizabeth de Lange
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Discovery of Antibiotics and Their Targets in Multidrug-Resistant Bacteria
PhD defence
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New discoveries by the Leiden-Turin excavations in Saqqara
Archaeologists from the National Museum of Antiquities (Leiden), the Museo Egizio (Turin, Italy) and Leiden University have found the grave of Panehsy, the 'steward of the temple of (the god) Amun', in Saqqara.
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Discovering and developing drugs
Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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The archaeological discovery at the Paardenmarkt in Alkmaar
In the summer of 2010, a special archaeological find resurfaced when plans to redevelop the Paardenmarkt, a parking lot in the historic city center of Alkmaar, began.
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Opening of the academic year
University ceremony
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Gli artigiani e la città
Over the last decades, the systematic investigation of urban settlements in Central-Tyrrhenian Italy led to the discovery of a growing number of contexts revealing both direct and indirect evidence of artisanal workshops. Such research commitment has yielded a vast amount of new data that greatly contribute…
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Met de voeten in het water
Publication on the excavations at Roman fort Matilo in Leiden
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Bhattacharyya Lab - Quantum transport in 2D materials
The research group of Semonti Bhattacharyya at the Leiden Institute of Physics studies quantum transport measurements in Van der Waals heterostructures.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri
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Extremely loud & incredibly far: observing radio bright AGN into the cosmic dawn
In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Chemical tools to monitor and control human proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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The Palaeoproteomic Identification of Pleistocene Hominin Skeletal Remains:
Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort
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Hunting dark matter with X-rays
Promotor: A. Achúcarro Co-promotor: A. Boyarsky
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Valorisation
In order to realise high quality valorisation of scientific research, eLaw practices valorisation activities during all stages of its research, i.e., not only after finishing research, but also prior to and during research.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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The social history of labor in the Iranian oil industry (1908-1954)
This PhD research sets out to unravel and explain the socio-structural and cultural impacts of oil-industrialization on the local Bakhtiari community in general and the industrial laborers it provided in specific.
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Representations of Minamoto no Yoshitsune in Visual Culture and Literature: Cultural Memory in Late Edo and Meiji Japan
This project examines changes in late eighteenth and nineteenth-century representations of the legendary twelfth-century general Minamoto no Yoshitsune (1159-1189) and how they reflect not only developments in themes of representation, but also changes in the focus of early modern and modern Japan’s…
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Radio galaxies near the epoch of reionisation
This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
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Freek Vonk gets his own show on Discovery Channel
Biologist Freek Vonk had already appeared in the Time Warp programme, where he was shown milking a snake for its venom, which he needed for his doctoral research. On Friday 18 September, he explained his fascination for snakes to Matthijs van Nieuwkerk in ‘De wereld draait door’, a Dutch news and entertainment…
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NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Turaj Atabaki
Faculty of Humanities
t.atabaki@hum.leidenuniv.nl | +31 71 527 2171
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Cyra Akila Choudhury
Faculteit Rechtsgeleerdheid
c.choudhury@law.leidenuniv.nl | +31 71 527 8838