The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

This project proposes an integrated and comparative study on the syntactic, semantic, prosodic and processing aspects of in-situ wh-questions, taking the Grammar-parser correspondence hypothesis (Phillips 1996, 2003) as a guiding principle.

This study explores regional variation in the use of utterance-final particles by analyzing spoken Taiwan Mandarin data recorded from spontaneous conversations.

Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

This thesis introduces the concept of

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Conference

Education & outreach

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

Research training projects in the MCBIM group - Bachelor and master students of all chemistry related studies are more than welcome to take part in our research activities. We have various research projects, all in one way or another involving transition metal ions. Daily supervision in the laboratory…

Contact Biophysical Organic Chemistry/Solid State NMR

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

The one-year master’s in Linguistics is concerned with the knowledge, structure and use of language, studied from a wide range of perspectives. It trains students to systematically identify, describe and analyse language phenomena and to apply this knowledge to a specific area of interest.

Psycholinguistic research

In this project, we plan to combine two strands of research in speech processing: (a) the impact of prosody on speech processing and (b) the impact of musical training on speech processing. In our project we will test 8 year-old children with different degrees of musical training: (a) primary school…

Contact Supramolecular & Biomaterials Chemistry

Contact Theoretical Chemistry

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

With a MSc in Chemistry you are well prepared for a wide range of career opportunities. The chemical industry is one of the largest contributors to economic prosperity worldwide.

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.

Conact the Cellular Chemistry group

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

Contact information & address

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

Inaugural lecture

Research and education at the Leiden Institute of Chemistry is overseen by the Institute Board. The Board and representatives of the two research themes form the Management Team. The Scientific Council (WERA), the Institute Council (I-Raad) and the platform for PhDs and post-doctoral co-workers (LIC73)…

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Coordination chemistry is the chemistry of metal atoms