1,467 search results for “bacterial stress” in the Public website
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The environmentally-regulated interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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Regulation of autophagy-related mechanisms during bacterial infection
PhD defence
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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equality in the past with a VIDI grant: ‘We will look for indications of stress’
Dr Sarah Schrader, an expert in the study of human remains, received a VIDI grant for a research project on health and inequality. In present day people with a high socio-economic status encounter fewer health risks than those in lower socio-economic strati. ‘Now we will look at this process in the…
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Quest for new antibiotics
Gubbens
- Facilities
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Projects
An overview of Quantitative Pharmacology projects
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Stressed-out Stress Systems
PhD defence
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Cryotomographic visualization of symbiosis initiation in the Euprymna scolopes-Vibrio fischeri association
The overall aim of this project is to understand, on the molecular level, how the bacterium V. fischeri cells interacts with their squid host.
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Anthropogenic effects on links between macro-invertebrate diversity and ecosystem functioning
How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Priyanka Chopra
Science
p.chopra@biology.leidenuniv.nl | +31 71 527 1886
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Stephanus Huijbregts
Faculteit der Sociale Wetenschappen
shuijbregts@fsw.leidenuniv.nl | +31 71 527 1723
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Hans Slabbekoorn
Science
h.w.slabbekoorn@biology.leidenuniv.nl | +31 71 527 5049
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Renate Buisman
Faculteit der Sociale Wetenschappen
r.s.m.buisman@fsw.leidenuniv.nl | +31 71 527 3441
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Maximilian König
Faculteit der Sociale Wetenschappen
m.konig@fsw.leidenuniv.nl | +31 71 527 6619
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Daan Scheepers
Faculteit der Sociale Wetenschappen
scheepersdt@fsw.leidenuniv.nl | +31 71 527 3642
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Marret Noordewier
Faculteit der Sociale Wetenschappen
m.k.noordewier@fsw.leidenuniv.nl | +31 71 527 8852
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Swimming Bass under Pounding Bass: fish response to sound exposure
Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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How to make an old antibiotic a hundred times more potent
Nathaniel Martin, Professor of Biological chemistry, wondered what would happen if you take an antibiotic that has been known for 70 years and try to improve it with the latest tools of modern chemistry. Turns out it can become up to a hundred times more potent and prevent the growth of some drug-resistant…
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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Efficient and flexible platform to isolate and study bacteriophages
We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
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Chemistry & Chemical Biology approaches toward novel cyclic peptide antibiotics
Can cyclic peptides provide a new generation of antibiotics?
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Biosafety Level 3 laboratory
Within the Leiden University Medical Center (LUMC) several research projects use pathogenic microorganisms of risk group 3. For working with these pathogens, the LUMC has a high containment research lab to safely perform the experiments for man and environment.
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New IBL-professor in Ultrastructural Biology: Ariane Briegel
Ariane Briegel has been appointed Professor in the fìeld of Ultrastructural Biology within the Faculty of Science at the Institute of Biology from the 1st of December 2015. Her expertise is in using electron cryotomography to study how microbes sense and respond to their environment.
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Research
Although there has been an increase in the research into brain function and dysfunction in relation to stress and emotions, there are still many unanswered questions.
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Phonetic experiments on the word and sentence prosody of Betawi Malay and Toba Batak
In this study Lilie Roosman describes the effects of prominence and boundary marking on the temporal and melodic structures of two regional languages of Indonesia, viz. Toba Batak, a stress language, and her native language Betawi Malay, a non-stress language.
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Students hunting for breakthrough in antibiotics resistance
Bacteria that fluoresce green, blue or red may play a role in combatting resistance against antibiotics. Under the motto of 'Say yes to stress', thirteen ambitious Leiden students are aiming to amass 9,000 euros to carry out their research project.
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Members
LIBC Stress & Emotion is a network focusing on science valorisation and outreach, stimulating interdisciplinary exchange of knowledge and expertise on topics related to brain and cognition/Stress and Emotion. Its research members come from a broad and diverse spectrum of specialized academic fields…
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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About us
All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.
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The battle against antimicrobial resistant bacterial infections - next stage development of antimicrobial peptides
PhD defence
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PhD Theses
A full overview of MacBio PhD Theses.
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?
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Respiratory-chain enzymes
Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf
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Institute of Biology Leiden
The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.
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In Pursuit of Next-Generation Lipopeptide Antibiotics
Can new variants of daptomycin and the polymyxins be found?
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INFLANET - Training European Experts in Inflammation: from the molecular players to animal models and the bedside
How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?
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Breaking the witches' spell: towards steering the soil microbiome for volatile-mediated control of the root parasitic weed Striga
Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.
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Screening of animal venoms for antimicrobial compounds
Can animal venoms yield novel antimicrobial peptides?
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Individualized dosing of aminoglycosides and glycopeptide antibiotics in (morbidly) obese patients (AMIGO)
Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).
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Graduate School of Science
Are you graduating at the Faculty of Science? Or are you supervising a PhD student? At the Graduate School of Science you find support at every phase of your PhD.
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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The dynamic organization of prokaryotic genomes: DNA bridging and wrapping proteins across the tree of life
Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.
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Fast vaccine design and development based on correlates of protection (COPs) Influenza as a trendsetter
New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.