745 search results for “acoustic signal” in the Public website
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Dynamic Nuclear Polarization agents
Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…
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Weak coupling between magnetically inequivalent spins: the deceptively simple, complicated spectrum of a 13C-labeled trimethyl amine
A deceptively simple, complicated paper
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A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunits
Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Exploring future multi-messenger Galactic astronomy
For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.
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Singing is silver, hearing is gold: impacts of local FoxP1 knockdowns on auditory perception and gene expression in female zebra finches
The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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The impact of defense hormones on the interaction between plants and the soil microbial community
The soil ecosystem consists of the largest reservoir of biodiversity on Earth.
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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Key publications
Key publications of the Cancer Drug Target Discovery group
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Regulation of TGF-β signaling and EMT in cancer progression
PhD defence
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Contextual glucocorticoid signaling in-vivo: A molecular perspective
PhD defence
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Understanding the complexity of TGF-beta signaling in cancer
PhD defence
- Week 3: 19–25 January, 2020
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From Big Bang to algorithm
Smart algorithms and powerful processors are just as essential for astronomy as big telescopes. Astronomers at Leiden University therefore constantly operate at the interface between astronomy and data science.
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Can humans observe a single particle of light? (And what does that say about our brain?)
Hoping to learn something about the human brain, Leiden researchers are creating a setup to shoot single photons, particles of light, into someone’s eye. ‘The eye is a passageway to the brain.’
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Search for cosmic neutrinos with ANTARES
Promotor: Prof.dr. M. de Jong, Co-Promotor: Dr. A.J. Heijboer
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Extended Piano Techniques in Theory, History & Performance Practice
So-called
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New sports and exam centre
Leiden University is currently preparing the development of a new sports and examination center in collaboration with the construction and design firm Binx Smartility. The current sports and examination center no longer meets sustainability requirements and is also becoming too cramped.
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Modelling phonologization: Vowel reduction and epenthesis in Lunigiana dialects
This dissertation provides a formal description of the relationship between diatopic/diachronic micro-variation and phonologization through analysis of the phonetic/phonological properties of unstressed vowel reduction and vowel insertion in two Northern Italian dialects.
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Symposium Transformations of the Audible / 16-18 May 2019
Sonorous phenomena are always on the verge of becoming something else. As it unfolds, sound constitutes spaces, mediates presence, articulates time. Furthermore, it may prompt emotions, generate awareness, organise patterns of behaviour or trigger a sense of belonging. As sound becomes audible, it is…
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Bird behaviour and environmental health in the context of anthropogenic threats to wildlife and nature in China
We study the link between the acoustic, behavioral and physiological health of birds and prominent pollution factors. We aim to explore causation through experimental studies on detrimental factors like traffic noise, particulate matter and chemical toxins. Our primary target is scientific progress…
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Gorlaeus Building
Leiden University is realizing a new and sustainable building with state-of-the-art research and education facilities for the Faculty of Mathematics and Natural Sciences, the Gorlaeus Building. The construction of the second phase, completed in January 2024, has resulted in a further expansion of the…
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Extended piano techniques : in theory, history and performance practice
Playing the piano with your forearm, plucking the strings, sawing through the piano: pianist Luk Vaes's doctoral dissertation covers all the techniques of play for which a piano is NOT designed. His defence ceremony will consist of three concerts and a public defence. 'Musicians were using the interior…
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Microbial Chemotaxis
In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.
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Different components of impulsivity in relation to emotional stress in patients with Borderline Personality Disorder and patients with Attention
How does stress affect different components of behavioral impulsivity and aggression in patients with Borderline Personality Disorder compared to clinical controls (patients with Attention Deficit Hyperactivity Disorder) and healthy controls?
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Evolutionary diversification of Nepenthes (Nepenthaceae)
Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes
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Stefan Semrau Lab - Quantitative Single-Cell Biology
We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.
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Time Domain Imaging of Transient and Variable Radio Sources
This thesis focuses on the study of transient and variable radio sources in the universe.
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Humanities Campus
Humanities Campus Project is the name of the redevelopment of the Witte Singel-Doelen Complex, the location of the Faculty of Humanities and associated knowledge partners and institutes. Over a period of ten years the complex will undergo a gradual metamorphosis, while classes continue to be taught.…
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
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Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen
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The details of past actions on a smartphone touchscreen are reflected by intrinsic sensorimotor dynamics
Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Here, we recorded all touchscreen smartphone interactions at a sub-second precision and show that the unconstrained day-to-day behavior captured on the phone reflects in…
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Programme structure
The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.
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Zebra finches discriminate wit from wet
Can Zebra finches learn to distinguish two very similar Dutch words? Research by behavioral biologist Verena Ohms proved that they can identify 'wit' and 'wet'. Ohms published her findings in
- LED3 Lecture: Designing Modulators of Purinergic Signaling for Chronic Disease Treatment
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Regulation of signal transduction pathways by hypoxia in breast cancer subtypes
PhD defence
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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Early intervention in behavioural problems at school
Leiden University social scientists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.
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Chemical Probe Facility
The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…
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Preventive Intervention Team
Leiden University neuropsychologists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.
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Robots and burial mounds
Neural networks have a wide range of applications. In Leiden, psychologists use them to build robot brains, whereas archaeologists use them to hunt for prehistoric graves.
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Role of Chemokine Gradient Sensing in Ewing Sarcoma Progression, Angiogenesis and Immune Targeting
What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
PhD defence
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development of molecular tools for investigating NAD+ metabolism and signalling
PhD defence
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Glucocorticoid signaling in a rat model of post-traumatic stress disorder
PhD defence