2,069 search results for “computational biology” in the Public website
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The QSPainRelief consortium will improve the treatment of chronic pain
The €6.24 million EU-funded research project QSPainRelief has kicked off. The project aims to help patients suffering from chronic pain with novel, personalised combinational treatments and is coordinated by Elizabeth de Lange from the Leiden Academic Center for Drug Research.
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No venom resistance in snake-eating birds: ‘They just don’t need it’
To eat or get eaten. It describes the evolutionary race of snakes versus the mammals and birds that prey on these snakes. Muzaffar Ali Khan devoted his PhD to investigating the molecular mechanisms play of the evolutionary arms race, and has his promotion 16 February. What makes mammals and birds successful…
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Can we live longer? Leiden physicist makes discovery in protective layer in genes
With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery…
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From politics to psychology: the power of games and play
The Bachelor Honours Class 'Homo Ludens: Why We Play' combines games, theory, and practice. Students dive into all aspects of humanity in which games play a part and discuss them, both on a theoretical an experiential level: 'Occasionally, you touch upon what play is, but then it eludes you.'
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Test certificate could help reopen society, but at what cost?
On 11 May the House of Representatives voted in favour of a law that will enable some sectors to reopen sooner than planned with the aid of test certificates. Political philosopher Josette Daemen is critical of the new legislation. ‘Just because we get used to measures doesn’t make them desirable.’
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Microbes protect crops from microbes
Farmers do not love them all. Microbes can cause tragic consequences for crops. Even the presence of just one pathogenic fungus or bacterium can drastically reduce yields. Still, there are exceptions. In that case, a pathogenic microbe is present in the soil, but does not cause any harm. Adam Ossowicki…
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Interview with PhD student: Doris van Bergeijk
Leiden University is partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH interviewed Doris van Bergeijk: PhD student of the project…
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Better understanding of disease thanks to organs-on-chips
For medical research, researchers often recreate tissue in the lab. Organ-on-a-chip technology emulates organs, right down to the blood that flows through them, thus creating a realistic test model for drugs or research into disease processes. Researchers from the LUMC are coordinating an NWO Gravitation…
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Eric Jorink: 'We want to map the tradition of observations'
The Netherlands Organisation for Scientific Research has awarded a grant of 750,000 euros to the 'Visualising the Unknown in 17th-century Science and Society' project. Researchers will reconstruct how seventeenth-century scientists recorded and shared their groundbreaking microscopic discoveries. We…
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Start project A New History of Fishes
The NWO just announced the results of the Vrije Competitie proposals. Paul Smith, professor at the French department is, as a member of LUCAS, one of three scholars within the Faculty of Humanities at Leiden University who has been awarded this grant.
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Virtual preparation for lab practicals
How can we better prepare students for their practicals, so that they learn more from them? Marjo de Graauw and her colleagues want to renew science education. Together they will develop interactive teaching materials to introduce students to laboratory courses. They are receiving a SURF grant of €100,000…
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Biologist Carel ten Cate will now really retire. Right?
Pigeons, zebra finches and parakeets. Carel ten Cate studied bird sounds. But not just that. Together with linguists from Leiden, he investigated parallels between birdsong and language. On 9 June, his farewell symposium was held to mark the end of his broad career. Well, the end? Carel ten Cate has…
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Can we predict the future of ecosystems throughout the world?
To what extent does human intervention influence the world’s biodiversity? And can we predict how biodiversity and ecosystems will change in the coming years? Inaugural lecture by Peter van Bodegom, Professor of Conservation Biology, on 8 May.
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Students solve spider mystery in Borneo
They sprayed with corn starch and made detailed drawings of the genitalia of spiders. In different ways students studied spiders in the dense tropical rainforest of Borneo. With their work they solved a spider mystery and published about this in Biodiversity Data Journal in April.
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Cod behave differently in noisy environment
Underwater noise from seismic surveys affects the behaviour of Atlantic cod. These are the results of research by Leiden biologists in collaboration with colleagues from Belgium. During such surveys the fish are less active than usual and their circadian rhythm is disrupted; soon after exposure they…
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New measuring method facilitates drug research
Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.
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Dutch youth unfamiliar with native animal species
For the first time research has been done on species literacy in the Netherlands. Children in primary schools know about 1 in 3 native animal species. Publication in Biological Conservation.
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Aggressiveness of cancer cells halted
Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.
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Go study abroad!
Are you keen to immerse yourself in a new culture, broaden your horizons and make friends for life? If so, come to the Study Abroad Festival on Friday afternoon 14 October.
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Real-time solid-state NMR spectroscopy inside living cells
Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…
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Towards a liveable future
Humans have influenced nature since as early as the Ice Age, and over the past century man’s impact has become even greater with our many new technologies and a growing world population. Leiden researchers study this impact and how we can keep it within reasonable limits so that nature can be preserved.…
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Fighting diseases with good bacteria
Researchers from the Institute of Biology Leiden have discovered how good intestinal bacteria regulate our innate immune system. This surprising discovery could make it possible to treat diseases related to inflammation, such as diabetes and colitis, with a cocktail of good bacteria. Publication in…
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Attacking tuberculosis bacteria: an interview with Mónica Varela
This summer postdoctoral researcher Mónica Varela from the Institute of Biology Leiden was awarded a Veni grant from the Dutch Research Council (NWO). Six questions about her project and hopes for the future.
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How drugs work better when encapsulated in nanoparticles
Chemist Tobias Bauer discovered ways to improve drugs by encapsulating them. Packages with iron nanoparticles, for example, can stimulate immune cells. Bauer will receive his PhD on 9 June.
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How a pathogenic bacterium searches for food
Bacteria whirl around in the mouths of most people, forming dental plaques and sometimes causing nasty gum infections. Treponema denticola might be a dangerous pathogen, but not much is known about this bacterium. It was up to Ariane Briegel and her research group to change that.
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Laura Heitman uses her expertise to fight cancer
Seven talented female scientists join the fight against cancer of the Oncode Insitute. Laura Heitman of the Leiden Academic Centre for Drug Research is one of the new Junior Investigators. ‘I hope to discover new druggable targets’.
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Students on expedition to Borneo
Every two years, students from Leiden University go into the Malaysian rainforests of Borneo. There they speak with Malaysian people to discover the use of plants or learn a local fishing technique. Improvising in the jungle leads to fruitful, creative, and important research.
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European project ImageInLife has started
The Horizon 2020 project ImageInLife has started on 1 January, followed by a kick-off meeting at the coordinating University of Montpellier at the end this month. This Marie Skłodowska-Curie training network brings together European groups that work on the imaging of vertebrates and offers fourteen…
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Children learn early on that scientists are men
When children were asked to draw a scientist, a bald, middle-aged man in a white coat was most often depicted. Why is that? A group of Leiden University science communication researchers discovered that children already get this impression in primary school. Published in PLOS ONE on 16 November.
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Bacteria under stress can live without cell wall
Thread-like bacteria make cells that no longer have a cell wall under the influence of osmotic stress. A remarkable discovery, since the cell wall serves as a protection barrier for bacteria. It could also help to explain how pathogenic bacteria can hide in our body from our immune system. A team of…
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Supergenes make bizarre traits possible
Within the same species of butterfly many different wing patterns can occur. How is this possible? According to researchers Ben Wielstra and Emma Berdan, of the Institute of Biology Leiden (IBL), the answer lies within supergenes. A supergene is a part of a chromosome that contains many strongly linked…
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Exploring the Bio Science Park
On 23 November, more than 70 students visited companies at the Leiden Bio Science. This second edition of the BSP Excursion included a fundamentals track and had a special focus on start-ups.
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ERC grant for Sebastian Pomplun to precisely influence gene expression
In order to stop a whole range of diseases or disorders at their source, you would have to be able to switch certain genes on or off. Sebastian Pomplun wants to develop substances that can do this very precisely. For example, he wants to disrupt cancer processes and make cells produce an important missing…
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A ‘lock’ to make genetic modification safer
Genetically modified organisms (GMOs) could be useful allies in the fight against critical environmental problems. Could because the use of GMOs is strictly regulated at the moment. A Leiden student team is now trying to make these GMOs safer with the aid of an ingenious lock.
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Ten thousand types of plant outgrowths bundled
For nine years he worked on the three-volume standard work Plant Galls of Europe. It yielded 2300 pages about 10,000 species of European galls, abnormal outgrowths in plants caused by parasites. Hans Roskam from the Institute of Biology Leiden: ‘The abundance of galls says something about the natural…
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Elizabeth den Hartog: ‘I always knew I wanted to go into academia’
Art historian Elizabeth den Hartog has been studying medieval sculpture at Leiden University for 32 years. Like a detective, she searches buildings, books and archives in the hunt for the cultural meaning of unique sculptures.
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Decomposing tears in order to detect Dry Eye Disease
By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…
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Bacteria that degrade plastic: Unilever Research Prize for master’s student Jo-Anne Verschoor
Jo-Anne Verschoor wins the Unilever Research Prize 2020. The master's student in Biology developed a method to test whether bacteria are capable of degrading plastic. Verschoor: 'Using specific enzymes from these bacteria, we may be able to efficiently recycle plastic in the future.
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Kistemaker obtains PhD cum laude on production of ground-breaking molecules
A month ago it was Marc Baggelaar, and now Hans Kistemaker too has obtained his PhD cum laude at the Leiden Institute for Chemistry (LIC). ‘He has made ground-breaking contributions to the world of protein modification,’ says PhD supervisor Gijs van der Marel. Kistemaker obtained his PhD on 11 May…
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Leiden researchers join forces against tuberculosis
About one and a half million people worldwide die each year from tuberculosis. For thirty years, therapy with antibiotics has been the same, while it takes far too long and can lead to resistant pathogens. Leiden researchers from four institutes are now joining forces to develop more effective and efficient…
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Humanities & Science students barbecue together
To celebrate the end of the semester the Science and Humanities Buddy Programme organised a barbecue together, which has become a small tradition. The barbecue marks the third co-organised activity between the two Programmes and helps to bring international and Dutch students together. The Buddy Programme…
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What do maths and blood clots have to do with each other?
Mathematics can help predict thrombosis. Mathematician Mark Alber has developed models that even aid in suggesting treatments. In the Kloosterman lecture on 27 June, he will explain how this works.
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Seven Leiden professors elected new members of KNAW
Seven Leiden professors have been elected as members of the Royal Netherlands Academy of Arts and Sciences (KNAW). In total 23 new members will be inaugurated on Monday 13 September.
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LIC Lecture: Chemically fueled droplets; towards the synthesis of life
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LIC Lecture + drinks
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Xi’an Jiaotong University Day at Leiden University
16 April was a special day at the Faculty of Science. In honour of the collaborations with the Chinese partner university, it was declared Xi’an Jiaotong University Day.
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'Maths is just plain fun'
Gianne Derks is the MI’s new scientific director from 1 May. She has worked abroad longer than in the Netherlands and, after more than 27 years in Surrey, she dreams in English. Who is this new director and who or what managed to entice her to make the move to Leiden?
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Reimagining druggability using chemoproteomic platforms
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LIC Lecture: To Eat or Not To Eat: Leveraging Chemical Proteomics for the Study of Macrophage Phagocytosis
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Aris Politopoulos: ‘I use games as a teaching method'
In his lectures Aris Politopoulos combines archaeology with video games. He is one of the three nominees for the 2020 LUS Teaching Prize. 'A good teacher is always open to feedback from students.'