626 search results for “the design” in the Public website
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Abolfazl Sajadi
Science
a.sajadi@liacs.leidenuniv.nl | +31 71 527 4799
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Fault Lines Design/Research at KABK/Leiden University
Organized by the Lectorate Design Friday, December 14, 2018 KABK Auditorium 10:00-17:00
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Student agency in secondary school: The development of student agency in secondary schools
Student agency is defined as the ability to increasingly take control of the learning process. It is associated with better grades, well-being, motivation and self-confidence. This research aims to provide teachers tools to stimulate student agency and to monitor its growth.
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GraspOS - Next Generation Research Assessment to Promote Open Science
The concept behind GraspOS is to build the European Federated Open Metrics Infrastructure in a decentralised way, where: different types of data come together to create metrics; tools and services are developed to improve EU or global infrastructures but are also shared with national or institutional…
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PhD Theses
A full overview of MCBIM PhD theses.
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Remote participation in a hybrid classroom: Interacting with students with chronic illnesses
There are about 35,000 students with chronic illnesses in the Netherlands. If they cannot receive education in the classroom, they may be able to do so from home or a hospital with hybrid education. The question in this study is: how can interaction with the teacher and fellow students be promoted?
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Fast vaccine design and development based on correlates of protection (COPs) Influenza as a trendsetter
New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.
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Dissertation Joost Grootens awarded as one the Best Dutch Book Designs 2021.
PhDArts alumnus Joost Grootens’ book 'Blind Maps and Blue Dots: The Blurring of the Producer-User Divide in the Production of Visual Information’ has been selected in the competition the Best Dutch Book Designs 2021.
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Supramolecular polymer materials for biomedical applications and diagnostics
Self-assembly is an abundant process in nature and is vital to many processes in living organisms.
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Ultrasensitive in situ visualization of active glucocerebrosidase molecules
Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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Graphene at fluidic interfaces
In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…
- Leiden Institute of Advanced Computer Science
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Evaluation of (4-Arylpiperidin-1-yl)cyclopentanecarboxamides As High-Affinity and Long-Residence-Time Antagonists for the CCR2 Receptor
Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.
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Reading Arabic: legibility studies for the Arabic script
What is the cost of visual complexity? This dissertation sets out to determine the effect of the complexity of word formation on the legibility of Arabic and the role that vocalization plays in reading.
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Governance and Dispute Settlement in the Ireland/Northern Ireland Protocol
In this working paper, Dr. Joris Larik provides an analysis of the governance and dispute settlement mechanisms under the Ireland/Northern Ireland Protocol.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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UBC Europe – University-Business Cooperation in Europe
To goal of this project is to get a deeper, more comprehensive and up to date understanding of the state of University-Business Cooperations (UBC) in Europe, from the perspective of both the Higher Education Institutions and the business sector.
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DAMIOSO - data mining on high volume simulation output
Modern computer-aided simulation tools used by various industries produce gigabytes of data. But currently, they take days and even up to weeks of computation effort. To make the best use of all these data, the DAMIOSO project focuses on developing algorithms and tools for managing, mining, and optimizing…
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Iron complexes as electrocatalysts for the water oxidation reaction
In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.
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From closed museum spaces to inclusive cultural meeting points
As museums face more scrutiny and are being demanded to decolonize, there are opportunities for Dominican museums to adopt a critical perspective and turn their collections and exhibitions into connections to our cultural past, present, and future.
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Gorlaeus Bicycle Storage
Currently, the construction is underway for a large, covered bicycle parking facility with space for nearly 3000 bicycles. In the summer of 2024, the Gorlaeus bicycle parking will be ready for use.
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Language diversity in the psycholinguistic study of sentence form variation
On the 12th of December, Eleanor Dutton successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Eleanor on this achievement.
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.
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Leiden Journal of Pottery Studies 23
Leiden Journal of Pottery Studies 23, 2007
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists
Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)
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Verleden als leidraad: ijzertijdbewoning en landschapsinrichting in noord-oostelijk Noord-Brabant in verleden én heden
For a long time it has been thought that habitation and landscape organisation only changed significantly from the Roman Period onwards. However, many developments were already started long before Julius Caesar's Roman armies arrived in the southern Netherlands.
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Are we there yet? Advances in anytime-valid methods for hypothesis testing and prediction
Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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The @school project
Developmental considerations in the design and delivery of cognitive-behavioural therapy for adolescent school refusal
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Master Industrial Ecology
The master's programme Industrial Ecology (joint degree Leiden University and Delft University of Technology) is unique in the Netherlands and one of the few programmes in the world combining natural science, engineering, and social science for science-based solutions for sustainability problems.
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Optimization of Patient Flow through EMT Facilities Applying Dynamic Behavioral Simulation Models
This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…
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Active Learning Network
The active learning network joins together everyone interested in the subject to move the theme further within Leiden University. The SALTSWAT pilot program researches the ways forward for Leiden University.
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Squaramide-based supramolecular polymers
Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.
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Computer Systems, Imagery & media
The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.
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Probing molecular layers with low-energy electrons
Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…
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Get to know Industrial Ecology
Industrial Ecology is an emerging scientific discipline that takes a systemic approach to sustainability problems. An interdisciplinary approach, integrating an engineering, environmental and social science perspective is essential for sustainable development. The Master in Industrial Ecology is a co-operation…
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Get to know Industrial Ecology
Industrial Ecology is an emerging scientific discipline that takes a systemic approach to sustainability problems. An interdisciplinary approach, integrating an engineering, environmental and social science perspective is essential for sustainable development. The Master in Industrial Ecology is a co-operation…
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Design of dissolvable microneedles for intradermal TB vaccination
Tuberculosis is an infectious disease which is spreaded through the air. It is caused by Mycobacterium tuberculosis and it led 1.7 million people to death in 2016. This mortarlity rate is concentrated in developing countries such as Indonesia, Philippines, Pakistan, and South Africa. These numbers make…
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Figuring Things Out Together: On the Relationship Between Design and Collective Practice
Anja Groten investigates matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D)*.
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Figuring Things Out Together. On the Relationship Between Design and Collective Practice.
This dissertation explores matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D).
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ESO instrument METIS passes important design milestone
The METIS instrument that’s being built for ESO's future Extremely Large Telescope (ELT) in Northern Chile under the leadership of the Dutch Research School for Astronomy (NOVA) has reached an important milestone: the preliminary design has been approved.
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…
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Research Design in Political Science: The new book by Dimiter Toshkov is now out
The new book by Dimiter Toshkov - associate professor of Public Administration at the Faculty of Governance and Global Affairs - has been recently published by Palgrave Macmillan.